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HEMATOLOGY 2 > SECONDARY HEMOSTATIS > Flashcards

SECONDARY HEMOSTATIS Flashcards

1
Q

Coagulation factors are primarily produced in the

A

Liver

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2
Q

Made by Megakaryocyte and endothelial cells

A

The vWF and VIII:vWF

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3
Q

Increased factors in liver disease

A

Factor I and VIII

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4
Q

A Very good test to assess liver function in the acute setting because factor VII is needed for the extrinsic pathway

A

PT

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5
Q

Factor that Has the shortest half life of 6 hours

A

Factor VII

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6
Q

All deficiencies of coagulation factors are transmitted as _________ except for factor VIII and IX deficiencies which are transmitted as ________

A

Autosomal recessive ; x-linked recessive

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7
Q

Most concentrated of all the plasma procoagulants ; essential for platelet aggregation (links activated platelets through their GP IIb /IIIa platelet fibrinogen receptor) ; increases approximately 10 mg/dL per decade in the elderly

A

Fibrinogen

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8
Q

Fibrinogen 100 mg/dL or less than effect on PT and PTT

A

Prolonged

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9
Q

Factor II

A

Prothrombin

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10
Q

Factor III

A

Tissue factor / tissue thromboplastin / thrombokinase

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11
Q

Factor IV

A

Calcium ions

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12
Q

Factor V

A

Proaccelerin / labile factor / thrombogen

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13
Q

Mutant factor V

A

Factor V Leiden

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14
Q

Factors inactivated by protein C-protein S complex

A

Factors V & VIII

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15
Q

Factor V is not inactivated by the protein C and S complex which leas to

A

Excessive clot formation

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16
Q

Deficiency of factor V

A

Owren’s disease or parahemophilia

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17
Q

First factor to be affected by warfarin therapy ; shortest life span

A

Factor VII

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18
Q

FACTOR VII

A

Proconvertin / stable factor

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19
Q

Proconvertin half life

A

6 hours

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20
Q

Factor VIII

A

Antihemophilic factor A (AHF-A) / antihemophilic globulin (AHG)

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21
Q

Free factor ____ is unstable in plasma (it circulates bound to vWF) ; during coagulation, ______ cleaves ____ from vWF and activates it

A

Factor VIII ; thrombin ; factor VIII

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22
Q

Factor VIII deficiency

A

Hemphilia A or classic hemophilia

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23
Q

Refers to procoagulant portion ; measured by standard factor VIII assay and APTT ; markedly decreased in hemophilia A

A

Factor VII, Factor VIIIC, Factor VIII:C

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24
Q

Factor VIII complex that refers to the antigenic properties ; measured by immunoassays

A

Factor VIII:Ag

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25
Q

Factor VIII complex which refers to the portion responsible for for platelet aggregation in the presence of Ristocetin ; termed as the Ristocetin cofactor

A

Factor VIIIR:RCo

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26
Q

Factor VIII complex required for normal platelet adhesion

A

Factor VIII:vWF

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27
Q

Antigenic portion oof the Von willebrand factor ; previously termed factor VIII related antigen (VIIIR:Ag) ; measured by immunoassay

A

vWF:Ag

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28
Q

Largest molecule in plasma

A

Von willebrand factor

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29
Q

Has receptor site for both platelets and collagen

A

VWF

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30
Q

Primary platelet surface receptor for vWF

A

GP Ib / IX / V

31
Q

Factor IX

A

Christmas factor / antihemophilic B / plasma thromboplastin component (PTC)

32
Q

FACTOR X

A

Stuart prower factor

33
Q

Factor XI

A

Antihemophilic factor C / plasma thromboplastin antecedent

34
Q

Hemphilia C / rosenthal syndrome

A

Factor XI deficiency

35
Q

> 50% of cases seen in Ashkenazi Jews

A

Factor XI deficiency

36
Q

Factor XII

A

Hageman factor / glass factor / contact factor

37
Q

Factor deficiency with no bleeding tendency and has thrombotic tendency

A

Factor XII

38
Q

Factor XIII

A

Fibrin stabilizing factor / fibrinase / Laki-Lorand factor

39
Q

Uses 5 M urea clot solubility test for detection (Duckert’s test)

A

Factor XIII

40
Q

PREKALLIKREIN is aka

A

Fletcher factor

41
Q

HMWK

A

High molecular weight kininogen / Reid factor / Williams factor / Fitzgerald factor / flaujeac factor

42
Q

Also considered coagulation factors , collectively called before as platelet factor 3 PF-3

A

Phosphatidylserine

43
Q

Eight coagulation factors are enzymes that circulate in an inactive form called

44
Q

Zymogens

A

Prothrombin
VII
IX
X
XI
XII
PREKALLIKREIN
XIII

45
Q

Coagulation factors that act as cofactors

A

Tissue factor
V
VIII
HMWK

46
Q

INITKNRINSIC FACTORS

A

12, 11, 9, 8

47
Q

EXTRINSIC FACTORS

48
Q

COMMON PATHWAY FACTORS

A

10, 5, 2, 1

49
Q

Fibrinogen group

A

1, 5, 8, 13

50
Q

Thrombin sensitive group

A

Fibrinogen group

51
Q

Absent in aged serum

A

Fibrinogen group

52
Q

Vitamin k-independent

A

Fibrinogen group
Contact group

53
Q

Calcium dependent group

A

Fibrinogen group
Prothrombin group

54
Q

Fibrinogen group is increased in (PISO)

A

Pregnancy
Inflammation
Stress
Oral contraceptive intake

55
Q

Present in aged serum

A

Factors 7, 9 ,10

56
Q

Prothrombin group

A

2, 7, 9, 10

57
Q

Vitamin K dependent group

A

Prothrombin group

58
Q

Prothrombin group is adsorbed in the plasma using either

A

Barium sulfate or aluminum hydroxide

59
Q

Contact group

A

XII, XI, PK, HMWK,

60
Q

Vitamin k-independent group

A

Contact group

61
Q

Coagulation factors and coagulation proteins formed under conditions of vitamin K absence or antagonism ; do not participate in coagulation process

A

PIVKA (protein induced by Vit. K absence)

62
Q

The concept of coagulation process is used extensively to interpret ____ lab tests and to identify factor deficiencies

63
Q

Activates factor 1, 5, 8

64
Q

Tenase complex

A

Factors 9a, PF-3, calcium, 8a

65
Q

Protrhombinase complex

A

10a, PF-3, calcium, 5a

66
Q

Involved in all phases of coagulation, except in the contact phase

67
Q

NOT soluble to 5M urea

A

Stabilized fibrin clot

68
Q

Normal physiologic needs the presence of two cell types for formation of coagulation complexes

A

Tissue factor bearing cells
Platelets

69
Q

Coagulation in vivo can be described as occurring in two phases

A

Initiation
Propagation

70
Q

Occurs on tissue factor-bearing cells and generates 3% to 5% of total thrombin produced

A

Initiation

71
Q

Occurs on platelets ; produces 95% or more of the total total thrombin

A

Propagation

72
Q

Activates factor IX and X, producing enough thrombin to activate platelet and factors V, VIII, XI

73
Q

Coagulation proceed on activated platelet phospholipid membranes with the formation of ___:____ and __:___ complex, which produces a burst of thrombin that cleaves fibrinogen to fibrin

A

IXa:VIIIa and Xa:Va complexes

HEMATOLOGY 2 (7 decks)

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