Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Hematology > Secondary hemostasis - lab > Flashcards

Secondary hemostasis - lab Flashcards

1
Q

secondary hemostasis happens at the __

A

platelet membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

secondary hemostasis happens at the platelet membrane, the fluid phase inhibited by __

A

coagulation control proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

enumerate the classification of blood factors

A
  • substrate
  • zymogen
  • serine protease
  • cofactor
  • calcium
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

substance where an enzyme acts

A

substrate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

an enzyme precursor and the inactive forms of a coagulation factor

A

zymogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

serine protease is the proteolytic enzymes of __ and with the __ residue in active sites

A

trypsin family, reactive seryl amino acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

t or f: cofactors needs to be present in addition to the enzyme so a particular reaction will be catalysed.

A

true

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

binds serine protease

A

cofactor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

needed for activation of coagulation factors

A

calcium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

calcium activates the coagulation factors except the __

A

contact phase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

flips to the outer surface on activation and is the phospholipid surface on which clotting enzymes assemble and is the phospholipid surface on which clotting enzymes assemble

A

phosphatidylethanolamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

enumerate the factor/s present in common pathway

A

X, V, prothrombin, fibrinogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

enumerate the factor/s present in intrinsic pathway

A

VIII, IX, XI, XII, prekallikrein, HMWK

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

enumerate the factor/s present in extrinsic pathway

A

VII

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

enumerate the factors present in absorb plasma

A

I, V, VIII, XI, XII, XIII, prekallikrein, HMWK

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

enumerate the vitamin k dependent factors

A

II, VII, IX, X, XI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

enumerate the name of these coagulation factors in which, the active form is a cofactor

A

V - proaccelerin
VIII - antihemophilic factor
High molecular weight kininogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

active form of fibrinogen

A

fibrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

active form of factor II

A

thrombin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

active form of factor VII

A

serine protease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

enumerate the name of these coagulation factors in which, the active form is a serine protease

A

VII - proconvertin
IX - plasma thromboplastin component
X - stuart-power factor
XI - plasma thromboplastin antecedent
XII - hageman
XIII - fibrin stabilizing factor
prekallikrein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

enumerate the 3 stages of secondary hemostasis

A

1: Generation of thromboplastin
2: conversion of prothrombin to thrombin
3: conversion of fibrinogen to fibrin clot

23
Q

stage 1 - generation of thromboplastin is also known as the

A

enzymatic phase

24
Q

stage 2 - conversion of prothrombin to thrombin is also know as the

A

polymerization

25
Q

stage 3 - conversion of fibrinogen to fibrin clot is also known as the

A

coagulation/clotting

26
Q

a factor produced endothelial cells and megakaryocytes

A

von willebrand

27
Q

vWf is stored in a-granules of platelets and in ___ of endothelial cells

A

Weilbel-Palade bodie

28
Q

formation of complexes: TENASE

A

factor IXa, XIII, Calcium and PF3

29
Q

formation of complexes:
factor Xa, Va, calcium , PF3

A

prothrombinase

30
Q

formation of complexes

A
  • TF, factor VIIa, phospholipids, calcium
  • factor IXa, factor XIII, Calcium and PF3
  • factor Xa, factor Va, calcium , PF3
31
Q

pathway that stars at factor XII and culminates in fibrin polymerization

A

intrinsic pathway

32
Q

extrinsic pathway is also known as the

A

tissue factor pathway

33
Q

it is where both pathway meets and ends in formation of fibrin clot

A

common pathway

34
Q

fibrinogen group is also known as the

A

thrombin sensitive group

35
Q

fibrinogen: calcium and vit k

A

calcium dependent; vit K independent

36
Q

fibrinogen involves what factor?

A

I, V, VIII, XIII

37
Q

fibrinogen group: plasma and serum

A

present in plasma, absent in serum

38
Q

fibrinogen is increased in __

A
  • pregnancy
  • inflammatory response
  • women on oral contraceptives
  • stress
39
Q

what factor/s decreased in in-vitro storage

A

V and VIII

40
Q

prothrombin group involves what factor/s?

A

II, V, VII, IX, X, protein C and S

41
Q

prothrombin group: calcium and vit K

A

calcium and vit K dependent

42
Q

necessary for the synthesis of prothrombin in the liver

A

vitamin K

43
Q

prothrombin group: plasma and serum

A

present in serum and plasma

44
Q

prothrombin is present in serum and plasma except?

A

except factor II

45
Q

competes with vit K

A

coumarin drugs

46
Q

this require a calcium or a cofactor to bind with phospholipid surfaces

A

prothrombin

47
Q

factor/s activated in cold temp

A

VII, XI

48
Q

examples of vit K sources

A

leafy vegetables, bacteriodes fragilis, e. coli

49
Q

contact group: calcium and vit K

A

calcium and vit K independent

50
Q

contact group involves what factor/s?

A

XII, XI, Prekallikrein, HMWK

51
Q

not adsorbed, not consumed during coagulation

A

contact group

52
Q

contact group is relatively stable and requires contact of __ for activation

A

negative-charged surface

53
Q

these factor/s function in the activation of plasminogen and fibrinolytic system

A

prekallikrein and HMWK

54
Q

clot retraction: after the fibrin clot has been stabilized by what factor?

A

factor XIIIa

Hematology (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions