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Hematology 2 > Secondary Hemostasis > Flashcards

Secondary Hemostasis Flashcards

1
Q

Factor I

A

Fibrinogen

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2
Q

Factor II

A

Prothrombin

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3
Q

Factor III

A

Tissue Factor

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4
Q

Factor IV

A

Calcium

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5
Q

Factor V

A

Proaccelerin/ Labile factor

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6
Q

Factor VII

A

Proconvertin / Stable Factor

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7
Q

Factor VIII

A

Anti-hemophilic factor A

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8
Q

Factor IX

A

Christmas factor

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9
Q

Factor X

A

Stuart Prower Factor

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10
Q

Factor XI

A

Antihemophilic Factor C

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11
Q

Factor XII

A

Hageman Factor

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12
Q

Factor XIII

A

Fibrin Stabilizing Factor

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13
Q

Prekallekrin

A

Fletcher Factor

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14
Q

High Molecular Weight Kininogen

A

Fitzgerald Factor

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15
Q

What are the cofactors

A

Factor V & VIII

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16
Q

What are the serine proteases

A

Factor II, VII, IX, X, XI, XII

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17
Q

What are the Vit K. dependent factors?

A

1972

X, IX, VII, II

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18
Q

What is present in Barium Sulfate Adsorbed Plasma?

A

All except Vit K. dependent factors (1972)

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19
Q

Factor involved in all pathways

A

Factor IV (Calcium)

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20
Q

Factors involved in the extrinsic pathway

A

Factor III, VII, and IV (Calcium)

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21
Q

Factor Xa cleaves _ to _

A

Prothrombin (II) to thrombin (IIa)

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22
Q

Factor IIa

A

Thrombin

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23
Q

What does thrombin (IIa) cleave ?

A

Fibrinogen (I) to Fibrin

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24
Q

Factors involved in the intrinsic pathway

A

Factor XII, XI, IX, VIII(Cofactor), IV

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25
Q

Factors involved in the common pathway

A

Factor X, V(Cofactor), II, XIII, IV

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26
Q

Factor Xa converts prothrombin to thrombin with the help of _

A

Factor V

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27
Q

The most common acquired clotting factor deficiency

A

Liver disease

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28
Q

The most common inherited clotting factor deficiency

A

Hemophilia A

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29
Q

The inheritance pattern of Hemophilia A

A

X-linked recessive

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30
Q

Other name for hemophilia A

A

Classic hemophilia / Royal’s Disease

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31
Q

Deficiency in Hemophilia A

A

Factor VIII

32
Q

Factor V deficiency is otherwise known as _

A

Owren’s disease / Labile factor deficiency

33
Q

Hemophilia B deficiency

A

Factor IX (Christmas Disease)

34
Q

The inheritance pattern of Hemophilia B

A

X-linked recessive

*Note: Most factor deficiencies are autosomal recessive except Hemophilia A and B

35
Q

Factor XI deficiency

A

Hemophilia C (Rosenthal Deficiency)

36
Q

Major site of inhibition

A

Endothelium and platelets

37
Q

Major inhibitor of cofactors

A

Protein C

38
Q

Cofactor of Protein C

A

Protein S

39
Q

Vitamin K dependent inhibitors

A

Protein C and S

40
Q

Factors degraded by Protein C and S

A

Cofactors Va and VIIIa

41
Q

Major inhibitor of coagulation

A

Anti-thrombin III

42
Q

Forms a complex with thrombin, kallikrein and plasmin to inhibit their functions

A

Alpha-2 microglobulin

43
Q

Inhibits thrombin

A

Heparin / Heparin cofactor II

44
Q

Normal value for the micro method of clotting time

A

2-4 min.

Dale & Laidlaw’s and Slide drop method

45
Q

Clotting test that utilizes a capillary tube to note the clot formation

A

Dale & Laidlaw’s

46
Q

Clotting test that uses a glass slide, and lancet, and scoop the drop of blood every 30 sec. until fibrin string is produced

A

Slide drop method

47
Q

Clotting method wherein whole blood is submerged in a water bath of 37C

A

Lee & White (NV. 7-15 min)

48
Q

What pathway does PT measure?

A

Extrinsic and Common Pathway

49
Q

What pathway does APTT measure?

A

Intrinsic and Common Pathway

50
Q

Normal Value of Prothrombin time (PT)

A

10-12 sec.

51
Q

Normal Value of Activated Partial Thromboplastin Time (APTT)?

A

25-35 sec.

52
Q

The specific factor that PT and APTT are not sensitive to

A

FXIII

53
Q

The test of choice to monitor Heparin therapy

A

APTT

54
Q

Test of choice to monitor warfarin therapy

A

PT

55
Q

Reagent utilized in PT

A

Simplastin

contains thromboplastin to replace tissue factor and Calcium chloride

56
Q

The component in Simplastin (reagent in PT) to replace tissue factor

A

Thromboplastin

57
Q

The measure of sensitivity for the PT reagent

A

INR (International Normalized Ratio)

58
Q

The normal INR for PT

A

2-3

59
Q

Specimen needed for APTT

A

Platelet poor plasma (PPP)

60
Q

Tests that uses Platelet Poor Plasma

A
  1. APTT
  2. Stypven Time (Russel Viper Venom Time)
  3. Thrombin Time
  4. Reptilase time
61
Q

Determines problem in the common pathway only

A

Stypven Time (Russel Viper Venom Time)

62
Q

Snake where platelin is extracted from in the russel viper venom time

A

Vipera russeli / East Indian Viper (N.V.6-10sec)

63
Q

Tests that assess prolonged Fibrinogen deficiency

A
  1. Thrombin Time (TCT/TT)

2. Reptilase

64
Q

Thrombin time is unaffected/affected by heparin while reptilase is unaffected/affected by heparin

A

Thrombin: AFFECTED by Heparin
Reptilase: UNAFFECTED by Heparin

65
Q

Snake where the enzyme for reptilase time (resembles thrombin) is extracted from

A

Bothrops Atrox snake

66
Q

NV for Thrombin time

A

10-14 sec.

67
Q

Reagent for Reptilase time

A

Atroxin

68
Q

Test used for factor XIII

A

Duckert’s test (5M Urea Solubility Test)

69
Q

Normal result for the Duckert’s test

A

Factor XIII insoluble to Urea when incubated for 24 hrs

If solube=Factor XIII deficiency

70
Q

Blood: Anticoagulant ratio in a black tube

A

4:1

71
Q

Factors activated at cold temperatures

A

Malamig sa 7/11

FVII and XI

72
Q

Factors that will break down at temperatures above 37C

A

Labile Factors (7 &5)

FVII and V

73
Q

Recommended processing time of APTT

A

Within 4 hrs

74
Q

Recommended processing time for PT

A

Within 24 hrs

75
Q

Factors present in Fresh Plasma

A

All

76
Q

Factors not present in Aged Plasma

A

Cofactors V and VIII

Hematology 2 (3 decks)

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