Secondary Diabetes and Monogenic Diabetes

Question 1

What are some pancreatic causes of diabetes?

Answer 1

• Cystic fibrosis,
• Chronic pancreatitis
• Haemochromatosis
• Cancer

Question 2

What are some endocrine causes of diabetes?

Answer 2

• Cushing’s syndrome/disease
• Acromegaly
• Phaechromocytoma
• Thyrotoxicosis

Question 3

What are some drug causes of diabetes?

Answer 3

• Steroids,
• Atypical neuroleptics (antipsychotics)
• Thiazides
• Beta blockers

Question 4

What are some glycogen storage disorders which can cause diabetes?

Answer 4

• Type 1 (Von Gierke’s disease)
• Type 2 (Pompe disease)

Question 5

Name and describe a monogenic cause of diabetes

Answer 5

MODY (maturity-onset diabetes of the young). Autosomal dominant
It is the development of T2DM under age 25. Very sensitive to treatment with sulphonylureas

Question 6

What are the clinical features of MODY?

Answer 6

Often presents with mild non-ketotic hyperglycaemia.
Patient’s don’t tend to present with DKA however they are also often normal weight and do not show signs of insulin resistance