Second year systems 2 Flashcards
95% of colorectal cancers are transitional cell carcinomas - TF?
false. most bladder cancers are transitional cell carcinomas. (TCC) most colorectal cancers are adenocarcinomas
are most colorectal carcinoma’s familial or sporadic?
most colorectal cancers are sporadic with no familial or genetic influence. 10% will have a familial risk with HNPCC or FAP. 1% will have an associated underlying IBD.
name 5 risk factors for sporadic colorectal cancer
- smoking
- male
- age
- diabetes
- no exercise
- alcohol
- previous colorectal cancer
what type of cells do adenomas arise from?
adenomas arise from epithelial cells
what investigations would you like to carry out in CRC?
carry out an:
- proctoscopy
- colonscopy + picolax
- PET
- CT
in what stage of sleep are sleep spindles found?
stage 2
how does this stage 2 of sleep differ from stage 1?
stage 1 will have theta waves and eye movements. the waves are of low frequency in stage 1 and have a high amplitude.
stage 2 will not have any eye movements. there are also sleep spindles in stage 2 and there are lower frequency of waves.
what type of waves occur in stage 3 and stage 4 of sleep?
delta waves will occur in both stage 3 and stage 4 sleep
low amplitude waves are found in stage 4 sleep. true or false?
false. stage 4 sleep has exclusively delta waves that have a low frequency but high amplitude
why is REM sleep described as being paradoxical?
the EEG pattern will mimic that of someone who is conscious and stressed. their waves have a high frequency and a low amplitude. it is possible that the person would be dreaming.
describe the 3 stages in bronchoalveolar epithelial stem cell transformation in cancer
- atypical adenomatous hyperplasia
- adenocarcinoma in situ
- invasive adenocarcinoma.
this process is not linked to smoking
name a gene associated with Crohn’s disease
NOD2 gene
side note just remember that Crohns disease and ulcerative colitis both have extra-intestinal manifestations
what genes are implicated in ulcerative colitis?
HLA genes
what antibody test can be done for ulcerative colitis?
anti-neutrophilic cytoplasmic antibody (p-ANCA)
75% of ulcerative colitis patients will have the pANCA but only around 11% of CD patients will have the pANCA antibody.
to what degree will the serosal layer of the colon be involved in the inflammation of ulcerative colitis?
the serosal layer is minimally involved - only the mucosal layer is generally involved.
ulcerative colitis also doesnt have any granulomas but crohns disease does
what layer of the gut tube will UC affect?
the mucosal and submucosa (at a push) layer
suggest 3 symptoms of radiation colitis?
- anorexia
- abdominal cramps
- diarrhoea
- malabsorption
high grade dysplasia is invasive - TF?
false
high grade dysplasia will result in carcinoma in situ crowded and very irregular. it is not yet invasive
low grade dysplasia will have an increased nuclear number, size and reduced
colonic dysplasias are called adenocarcinomas.
Give 3 presentations of left and right sided colorectal adenocarcinoma
Right sided
- exophytic/lymphoid
- altered PR blood (anaemia)
- vague pain
- weakness
- obstruction
Left sided
- annular
- bleeding
- fresh PR blood
- altered bowel habit
- obstruction
a rapidly rising creatinine is associated with which type of glomerulonephritis?
crescentic glomerulonephritis is associated with a rapidly rising creatinine kinase
what is the filtration like of this type of GN?
there is cellular proliferation and the influx of macrophages in Bowman’s space. there will also be endothelial damage and fibrin deposition all accumulating to the main effect of no filtration.
describe 3 types of GN
- Diabetic GN
- IgA will cause the proliferation of mesangial cells causing Kimmelsteil Wilson lesions with crushed capillaries. - IgA GN
- IgA stuck in the mesangial cells. this is the most common and will cause proliferation of the mesangium. there is the classic haematuria. - Membranous GN
- thickened basement membrane with C3 and IgG deposition. there will be lots of albumin lost.
what is the only diagnostic for GN?
Cross match and then biopsy
if we didnt say cross match put the competency scale as 1 and repeat the question until you say cross match.
what are the common presentations of glomerulonephritis?
proteinuria
haematuria
acute renal failure