Second Exam Lecture Flashcards
What is biotechnology
A living biological entities used to produce a product
T/F: Biotechnology is made in vivo synthesis
True
What can products be for biotechnology
sugars, peptides/enzymes, nucleic acids, modified cells and tissues
What are techniques to make DNA
CRISPR,PCR
What are characteristics of small molecule drugs
low molecular weight, organic or chemical synthesis, know structure, easy, usually not immunogenic
Biologic drugs
high molecular weight, living organisms, many critical steps and difficult characterization, heterogeneous, often immunogenic
What are important considatations
biologics are less stable, never assume storage, always do homework on each biologic before working on it
Where can important considerations be found
Package inserts, purple book (biologic products)
T/F: Biosimilar is the same as generic
False: They are not interchangeable (especially in biologics)
What are vaccines
any foreign substance that is injected into a patient to create immunity to a disease
T/F:Vaccines should be left cool
True
T/F: Subunit and recombinant vaccines use specific peices of the germ (surface proteins)
True
T/F: VLP are multimeric structures assembled from viral structural proteins
True
What vaccines have been made form VLPs
Hepatitis and HPV
What is conjugate vaccine
poor antigen to a strong antigen bu covalent bond (usually polysacchride to protein)
What are toxoid vaccines
immunity is created for the toxin but not the germ itself
What are DNA vaccines
antigen is anything encoded by DNA
What happens in DNA vaccines
transcribed to mRNA, mRNA to protein, protein is degraded by proteosomes into peptides, peptides are MHC class 1 presented
T/F:Biologics should be cold
True
T/F: Flu viruses are mixes
True
What are the licenses
For the process
