Second Deck Flashcards
Neurohemal Organs
organ consisting of neurosecretory neuronal terminals and the capillary vessels that the nuerosecretory hormones are released into
Neurohemal Organs
organ consisting of neurosecretory neuronal terminals and the capillary vessels that the nuerosecretory hormones are released into
Cell chords and Sinusoids
endocrine cells in rows (chord)
Blood capillary or sinus spaces are in between rows
Follicles
endocrine cells arranged as hollow ball structure
capillaries are usually on the outer surface of follicle
secretion is to the blood capillary on outer surface
Diffused
no definite structural concentration of endocrine secretory cells
located in a diffused manner throughout tissue
pheromones
intraspecific
allelomones
interspecific
allomones
benefit releaser, interspecific
kairomones
benefit recipient, interspecific
Eicosanoids
phospholipid metabolites, usually metabolic products of arachidonic acid (prostaglandin, prostacyclins, thromboxanes)
Terpene derivatives
juvenille hormone of invertebrates
DI-Tyr + DI-Tyr
T4
MI-Tyr + DI-Tyr
T3 or rT3
MI-Tyr + MI-Tyr
T2
MI-Tyr + Tyr
T1
DI-Tyr + Tyr
T2
foregut fermenters
cows sheep
midgut fermenters
herbivorous fish
hindgut fermenters
horses, rabbits, elephants
all have longer cecum
Micelle
single layer fatty acids, monoglycerides, glycerol, and bile salts, with hydrophillic heads outside and hydrophobic tails inside.
can easily pass through microvilli membrane
Ghrelin
orexigenic hormone (hunger related) stomach is major source of ghrelin in blood. can be entrained by regular feeding schedule. can act on brain and locally to stimulate gastric acid release. stimulates pit GH secretion which in turn inhibits ghrelin release
Leptin
anorexigenic hormone - produced from adipocytes, reduces hunger and increases satiation. can be released by stomach into blood after feeding. can also act locally to decrease stomach acid secretion after feeding.
4 types of pathogens
virus
bacteria
fungus
parasite (water borne usually)
2 Branches of the immune system
Innate
Adaptive
Glycoprotein example
LH and FSH (both alpha and beta subunits)
Short peptide example
ACTH
Complex peptide example
Insulin
Modified amino acid example
Thyroid hormones
Steroid example
Testosterone, cortisone
Catchecholamines are
Modified amino acids
Example
Epinephrine and norepinephrine
Cytogenous
Whole cell released (sperm)
Sweet taste
PLC + gustductin
Sour taste
H+ ionotropic
Umami
PLC
Salty
Na+ ionotropic ENaC
Bitter
PLC
Bitter
PLC
Neural signalling
stimulate > neuron > target (pain reflex)
Endocrine signalling
stimulate > endocrine cell > blood stream > target (PTH for calcium regulation in blood)
Cytocrine signalling
stimulate > endocrine cell > Extra Cellular Fluid > target (histamine)
First order Neuroendocrine signalling
Stimulate > neuron > bloodstream > target (oxytocin - mammary glands)
Second order Neuroendocrine signalling
stimulate > neuron > endocrine cell > bloodstream > target
GnRH - seasonal reproduction
Inverse Neuroendocrine signalling
stimulate > endocrine cells > bloodstream > cross blood brain barrier > neurons (target)
(gonodal steroids)
Example of endocrine controlling endocrine
hypothalamus releases TRH to pituitary, which releases TSH to thyroid
Example of endocrine controlling exocrine
G cell releases gastrin into blood stream, which then acts on chief cell to increase pepsinogen production into stomach
Example of exocrine controlling endocrine
chief cell releasing pepsinogen into the stomach, which turns to pepsin, which breaks down protein to amino acid that can activate the G cell to produce gastrin into the blood stream
Example of endocrine controlling cytocrine
G cell producing Gastrin into the blood stream, which goes to the mast cell, which releases histamine
cytocrine control of exocrine
Histamine released from Mast cell, which goes to pareital cell which releases acid (cytocrine key is that it goes to extracellular fluid)
Periosteum
membrane that covers bone
Compact
Hard bone
Hematopoiesis
formation and differentiation of blood cells (hematopoietic stem cells are constantly renewing throughout your life)
Neutrophil granule function
directly damages pathogens
vasodillation
inflmattation
regulates proteases
Eosinophil granule function
induces reactive oxygen species formation
vasodiliation
basophil degranulation
antiviral activity
regulates other immune responses
attracts leukocytes (other white blood cells)
Basophil/Mast cell granule function
adaptive immune response regulation
smooth muscle activation
vasodiliation
inflammation regulation
Dendritic Cell Functions
Antigen capture
antigen presentation
important activators of T cells
Dendritic Cell Functions
Antigen capture
antigen presentation
important activators of T cells
C-type lectin receptors
(on phagocytes)
pattern recognition receptor type
mannans (bacteria, fungi, parasites) Beta glucans (fungi, some bacteria)
Scavenger receptors (on phagocytes) Pattern recognition receptor type
lipopolysaccharide lipoteichoic acid (bacteria)
Pattern recognition receptor types
C-type lectin receptors
Scavenger receptors
they directly facilitate the process
Opsonin receptor types
collagen-domain receptor
complement receptor
imminuglobulin Fc Receptors (IgE) and (IgM) and (IgA)
Recognize host molecules that stick
Complement system 3 pathways to activate
Classical
MB-Lectin
Alternative
Complement system Alternative pathway activation
pathogen surfaces goes through derived factors to C3 convertase
Complement system Classical pathway activation
antigen:antibody complexes (antibody surface) through derived factors goes to C3 convertase
Complement system MB-Lectin pathway activation
mannose binding lectin binds mannose on pathogen surfaces through derived factors goes to C3 convertase
3 actions of the complement system
Chemoattraction (C3a, C5a)
Opsonization (C3b)
Pathogen Lysis
Oxygen dependent killing
Reactive Oxygen Intermediates (ROI)
Reactive Nitrogen Intermediates (RNI)
monochloramine
Oxygen Independent Killing
Defensins
Tumor necrosis factor alpha (macrophage only)
Lysozyme
Hydrolytic enzymes
Neuromasts
on insects, detect water movement from other animals. on legs
cytocrine control of exocrine
paracrine
Histamine released from Mast cell, which goes to pareital cell which releases acid (cytocrine key is that it goes to extracellular fluid)
Chemical factors of innate immunity
fatty acids in sweat
enzymes in tears, saliva, mucus
low pH of sweat and gastric secretions
Defensins (antimicrobial proteins)
Physical factors of innate immunity
Skin movement (cilia, persistalis) Flushing (tears, saliva) Mucus Cough and sneeze reflexes Vomiting and diarrhea
Antibody functions
neutralization
agglutination
precipitation
complement activation
neutralization
masks dangerous parts of bacterial exotoxins:viruses (ferments the cell from binding to the surface off the cell)
Agglutination
cell bound antigens enhance phagocytosis
Precipitation
soluble antigens ferment the bad cell from binding to the surface of the cell
exogenous antigens players
professional APC exogenous antigen MHC class 2 Helper T cells TCR (specialized receptor) CD4+
endogenous antigens players
Infected host or altered host cell endogenous antigen MHC class 1 cytotoxic T cells TCR (specialized receptor) CD8+