Scores

Question 1

IV - UFH dose in massive PE

Answer 1

loading dose - 80 mg/kg

maintenance - 18 mg/kg/hour

Question 2

Therapeutic target of aPTT in massive PE

Answer 2

1.5 - 2.5 times

Question 3

Therapeutic target of INR

Answer 3

2.0-3.0

Question 4

Therapeutic target INT in mechanical valves

Answer 4

2.5-3.5

Question 5

Therapeutic target for Anti factor Xa

Answer 5

1. 2-1.5 IU mechanical valves

1. 0 -1.2

Question 6

<1.2 aPTT? in massive PE

actions?

Answer 6

Rebolus of 80 units/kg
dose change of +4 units/kg/hour
check aPTT in 6 hours

Question 7

1.2 - 1.5 aPTT? in massive PE

actions?

Answer 7

Rebolus of 40 units/kg
dose change of +2 units/kg/hour
check aPTT in 6 hours

Question 8

> 3.0 aPTT? in massive PE

actions?

Answer 8

stop infusion 1 hour
dose change of - 3 units/kg/hour
check aPTT in 6 hours

Question 9

Anti - Xa target values in PE? pulmonary embolism

Answer 9

target for AntiXa –>0.35 - 0.70 for UFH
Anti Xa in life threatening PE –> 0.5 - 1.0 units/ml – UFH
Anti Xa for LMWH therapeutic target–> 0.5 - 1.2
Anti Xa for LMWH therapeutic target –> mechanical valves –> 1.2- 1.5
Anti Xa LMWH Antithrombin

Question 10

Contraindications to LMWH

Answer 10

Known bleeding disorder (e.g. haemophilia, von Willebrand’s disease or acquired coagulopathy)
Active antenatal or postpartum bleeding
Women considered at increased risk of major haemorrhage (e.g. placenta praevia)
Thrombocytopenia (platelet count < 75 × 109
/l)
Acute stroke in previous 4 weeks (haemorrhagic or ischaemic)
Severe renal disease (glomerular filtration rate [GFR] < 30 ml/minute/1.73m2
)
Severe liver disease (prothrombin time above normal range or known varices)
Uncontrolled hypertension (blood pressure > 200 mmHg systolic or > 120 mmHg diastolic)