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Contact Lens 1 > SCL Solutions - Part 1 > Flashcards

SCL Solutions - Part 1 Flashcards

1
Q

Disinfectant

A

Eliminates harmful bugs from CL

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2
Q

Preservative

A

Controls growth of bugs

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3
Q

A care regimen has many roles…

A
  • Proven disinfection
  • Removal of deposits
  • Enhanced comfort
  • Has to be non-toxic, compatible w/ all materials, simple, quick, inexpensive!
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4
Q

Pros to heat disinfection (1970s)

A

Cheap
Simple
Very effective (pseudomonas, HIV, acanthamoeba)

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5
Q

Cons to heat disinfection

A 
Open to abuse (saline)
Increased deposits (baked onto lenses)
Increased red eye
Increased GPC
Distorted lenses
Not portable!
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6
Q

What are the original chemical disinfectants

A

Thimerosal (THI)
Chlorhexidine (CHX)
Benzalkonium chloride (BZK) - RGP ONLY!

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7
Q

Pros to chemical disinfection

A

Cheap
Portable
Simple
Effective

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8
Q

Cons to chemical disinfection

A

Open to abuse (topping up)
Discoloration (mercury turned lenses grey!)
Sensitivity issues (up to 40% after 3 yrs)

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9
Q

Four classic signs of preservative HS?

A

Red eye
Corneal staining
GPC
Corneal infiltrates

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10
Q

What concentration of hydrogen peroxide is used as a disinfectant?

A

3% (30 000 ppm)

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11
Q

What concentration of hydrogen peroxide is used as a preservative (in salines)?

A

0.006% (60 ppm)

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12
Q

At what concentration does hydrogen peroxide start to sting?

A

150-200 ppm

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13
Q

Problems w/ peroxide

A

Red eyes

Diffuse corneal staining

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14
Q

Most effective disinfecting system

A

3% peroxide soak overnight (neutralize in the am)

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15
Q

What is the problem w/ small preservatives/biocides?

A

Taken up into lens, leaving less for disinfection (reduced efficacy)
Subsequent release onto eye causes corneal staining or irritation

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16
Q

What preservative does Alcon solutions (Opti-free) use?

A

Polyquad

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17
Q

What preservative does B&L (Renu, BioTrue) use?

A

Polyhexanide (PHMB)

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18
Q

What preservative has the largest molecular weight?

A

High MW Polyquad

followed by High MW PHMB

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19
Q

What are the major biocides?

A 
Hydrogen peroxide
PHMB
Polyquad
Alexidine
Aldox
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20
Q

What are the major surfactants?

A

Tetronic 1107, 1304, 1304 plus C9-ED3A

Pluronic F-127

21
Q

What are the major wetting agents?

A

CMC
HPMC
HA
EOBO

22
Q

What are the major chelating agents?

A

EDTA
Sodium citrate
Hydranate

23
Q

What solutions use Peroxide as a biocide?

A

AOSept
ClearCare (AOSept Plus)
Ultracare (Oxysept 1-step)

24
Q

What solutions use Polyquad?

A

OptiFree Express
OptiFree RepleniSH
OptiFree PureMoist

25
Q

What solutions use PHMB? (Most of them…)

A 
ReNu Sensitive Eyes
ReNu Fresh
SoloCare AQUA
Complete Easy Rub
All in One Light
26
Q

What is Alexidine? What solution is it used in?

A 
Bisguanide antiseptic (used in mouthwash)
Related to chlorhexidine

Used in Complete RevitaLens (with polyquad)

27
Q

What is MAPD (Aldox)? What solution is it found in?

A

Fungicide

In OptiFree Express/RepleniSH/PureMoist

28
Q

What two preservatives are used in B&L Biotrue?

A

PHMB and Polyquad

29
Q

What are the two components of a surfactant?

A 
Hydrophilic head (water soluble)
Hydrophobic tail (water insoluble)
30
Q

What are the two functions of a surfactant?

A

Detergent (cleaner) - remove debris, deposits…

Aid in wetting of interfaces

31
Q

What are the three surfactants?

A

Poloxamer (Pluronic F87, F127)
Poloxamine (Tetronic 1304, 1107)
Aqualube (Cremophor RH40)

32
Q

What are the traditional polysaccharide-based wetting agents?

A

CMC
HPMC
HA

33
Q

Surfactant block copolymers (wetting agents)

A

Poloaxamines
Poloxamers
EOBO

34
Q

What solutions use Tetronic 1304 as a wetting agent?

A

Alcon OptiFree Express/RepleniSH, PureMoist

35
Q

What solutions use Tetronic 1107 as a wetting agent?

A

B&L - Renu Fresh/SensitiveEyes, BioTrue

36
Q

What solutions use Tetronic 904 as a wetting agent?

A

AMO RevitaLens

37
Q

What solutions use Pluronic F87 as a wetting agent?

A

AMO Complete Easy Rub

38
Q

What solutions use Pluronic 17R4 as a wetting agent?

A

CIBA Vision ClearCare

39
Q

What solutions use EOBO as a wetting agent?

A

OptiFree PureMoist

40
Q

What chelating agent is found in EVERY CL solution and binds metal ions?

A

EDTA

41
Q

How does EDTA work?

A

Binds metal ions that bugs need to metabolize

Acts synergistically w/ preservative to kill bugs!

42
Q

What is the ONE solution that doesn’t use EDTA?

A

OptiFree RepleniSH

43
Q

What solutions use sodium citrate as a chelating agent?

A

OptiFree Express/RepleniSH/PureMoist

44
Q

What does sodium citrate do?

A

Opens poles to help w/ protein removal

More relevant w/ older hydrogel materials

45
Q

What solution uses Hydranate?

A

Renu Fresh

46
Q

What does Hydranate do?

A

Opens pores to help w/ protein removal

More relevant w/ older hydrogel materials

47
Q

What are two ways to neutralize Hydrogen Peroxide, post-disinfection?

A 
Platinum disc (ClearCare)
Enzymatic (UltraCare - HPMC coated tablet, Vit B12 Indicator)
48
Q

How do Clear Care and UltraCare compare in speed of neutralization?

A

ClearCare starts neutralization right away. Swift decrease in peroxide concentration.
UltraCare neutralizes slowly for the first 25 mins… reaches same concentration of ClearCare after an hour.

Contact Lens 1 (8 decks)

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