CL Deposits Flashcards

1
Q

What are some issues associated w/ CL deposits?

A
Reduce acuity
Reduce comfort
Reduce wettability
Reduce wear time
Invoke inflammatory changes
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2
Q

How does the RUDKO grading system work?

A

Lens removed (in vitro)
Low magnification
Oblique lighting
Classify deposits (visibility, type, coverage)

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3
Q

What is the most common deposit and what is its appearance?

A

Protein

Thin, translucent appearance

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4
Q

What is the worst protein deposit and why?

A

Lysozyme - low MW and high +ve charge!

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5
Q

Which group of lenses has mostly lysozyme protein deposits (90%)

A

GIV (ionic, HWC)

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6
Q

How is protein removed from lenses?

A

Surfactants, enzyme removers (50-60% removal)

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7
Q

How does lens material affect lysozyme deposits?

A

More deposits on conventional hydrogel than SiHy

More DENATURED protein on SiHys

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8
Q

Which SiHy has most surface deposits of protein?

A

PureVision (plasma oxidation coating)

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9
Q

For group IV (Acuvue 2) where are the protein deposits happening?

A

In the bulk of the lens

small protein w/ opposite charge of lens material

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10
Q

For SiHys, where are the protein deposits happening?

A

On the front and back surface of the lens

Surface treatment prevents protein from moving into the bulk of the lens

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11
Q

What are lipid deposits? When are they a problem?

A

Greasy, shiny appearance

Problem for RGPs, GII SCl, SiHys

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12
Q

How do we remove lipid?

A

Surfactants

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13
Q

What are CALCULI?

A

Discrete, elevated deposits (90% lipid, 10% calcium)
Round or oval
Anterior surface of SCl only
Grow beneath lens surface

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14
Q

How do you deal w/ Calculi on lenses?

A

Replacement (removal leaves pits)

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15
Q

What are iron deposits?

A

Metallic FB embedded

Oxidize to form rust spots

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16
Q

What are mucin deposits?

A

Base layer for other deposits
Produced by goblet cells of conj
Problem w/ RGPs (plaque)

17
Q

What are calcium deposits?

A

Derived from tears or buffer agents
Carbonate = white crystals
Phosphate = white film

18
Q

How is calcium removed?

A

With chelating agent (EDTA)

19
Q

When are cosmetics migrating to tear film?

A

less than 30 mins after eye makeup application

20
Q

More protein seen in which FDA group?

A

GIV (MA concentration and WC)

21
Q

More lipid seen in which FDA group?

A

GII (NVP concentration & WC)