Schizophrenia Drugs

Question 1

Chlorpromazine and Thioridazine are what generation antipsychotics. What potency?
Side effects?

Answer 1

First gen antipyschotics
Low potency
Non-selective D2 receptor antagonism
Side effects: EPS, fatigue, weight gain, anticholinergic, orthostasis

Question 2

Fluphenazine, Thiothixine, and haloperidol are what generation antipsychotics. What potency?
Side effects?

Answer 2

First gen high potency antipsychotics
Non-selective D2 receptor antagonism
Side effects: EPS

Question 3

Clozapine is what generation antipsychotics. Which receptors does it antagonize?
Side effects?

Answer 3

Second gen antipsychotic
D2, D1, D4 recetpor antagonist
5HT2a receptor antagonist
Side effects include suicide risk in all ages <25, metabolic syndrome, TD/EPS, but ALSO risk of agranulocytosis so need to check WBC count
Of all antipsychotics, this has the highest metabolic risk

Question 4

Olanzapine, quetiapine, and asenapine are what generation antipsychotics.
Side effects?

Answer 4

Second gen antipsychotics
D2 receptor antagonist
5HT2a receptor antagonist
Side effects include suicide risk in all ages <25, metabolic syndrome, TD/EPS

Question 5

What is first line tx for schizophrenia?

Answer 5

atypical second generation to block D2 and 5HT2a receptors. They have fewer negative motor effects than typical antipsychotics (less EPS) but do have more metabolic side effects (weight gain, high lipids, DM II)

Question 6

Most antipsychotics block D2 receptors in the _______- DA pathway, to treat ______ symptoms

Answer 6

mesolimbic

positive symptoms

Question 7

Risperidone, Ziprasidone, Paliperidone, Iloperidone, and Lirasidone are what generation antipsychotics.
Side effects?

Answer 7

Second gen antipsychotics
D2 receptor antagonist with various other receptor agonism/antagonism
Fewer metabolic complications than the “pines” group of 2nd gen antipsychotics but more EPS

Question 8

What is the name of the antipsychotic used to treat Parkinson’s disease?

Answer 8

Pimavanserin

5HT2a antagonist