Schizophrenia~Cause

Question 1

Lifetime prevalence of Schizophrenia and number of people who suffer worldwide?

Answer 1

.3%-.7%
20 million suffer

Question 2

How many people in US have schizophrenia?
NIH

Answer 2

0.25%-.65% of people over 18 have schizophrenia

Question 3

Prevalence rate of schizophrenia in US?

Answer 3

1.5 per every 10,000 people

Question 4

Typical age of Schizophrenia diagnosis? What age is typically rare but can happen?

Answer 4

15-35 yrs typical
Childhood rare

Question 5

In general, the presentation of schizophrenia and course of illness are the same across genders

Answer 5

False
Occurs equally in males and females, bust course of illness can be different

Question 6

Late onset schizophrenia occurs predominantly in females? T/F

Answer 6

True

Question 7

Due to chronic nature of schizophrenia, prevalence rates are generally higher than incidence rates? T/F

Answer 7

True

Question 8

What is the highest familial genetic percentage risk of developing schizophrenia?

Answer 8

Identical twins - 79%
Offspring of one parent with Schizophrenia ~10%
Sibling 10%

Question 9

Individuals with close family members with schizophrenia are more likely to develop the disease than people without a relative?

Answer 9

True

Question 10

What is the risk for the general population for developing schizophrenia?

Answer 10

<1%

Question 11

What gene numbers are currently being investigated for a link to schizophrenia?

Answer 11

8, 13, 16, 22

Question 12

What are environmental risk factors for developing schizophrenia?

Answer 12

Perinatal hypoxia with fetal oxygen deprivation leading to brain damage

Question 13

Maternal exposure to influenza may increase the risk for some forms of schizophrenia? T/F

Answer 13

True

Question 14

There has been a decrease in the number of cases of schizophrenia since industrial age?

Answer 14

False

Question 15

Disruption of the neurodevelopment process during critical gestation period can lead to…?

Answer 15

Schizophrenia
Other mental disorders

Question 16

What are the 3 neurotransmitter pathways abnormalities currently believed to be involved in the development of schizophrenia?

Answer 16

1. Dopaminergic
2. GABA (gamma-amniobutyric acid)
3. NMDA (N-methyl-D-aspartate)

Question 17

What is a diathesis?

Answer 17

Bodily condition that denotes a predisposition to a disease

Question 18

What are 2 diathesis for schizophrenia?

Answer 18

1. Genetic abnormality disrupting fetal neural development
2. Exposure to teratogenic factor (Flu)

Question 19

What are 5 “stressors” in childhood that can lead to schizophrenia later?

Answer 19

1. Obstetrical complications -fetal O2 de;rivation
2. Childhood; head injury, illness, deprivation, trauma