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Pharmacotherapeutics - Midterm > Schizophrenia Case > Flashcards

Schizophrenia Case Flashcards

1
Q

8 clinical uses of antipsychotic agents

A

shizophrenia
bipolar
psychotic depression
senile psychosis
drug-induced psychosis
mood enhancement
anti anxiety
sleep disorders

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2
Q

3 first gen antipsychotics (FGA)

A

phenothiazines - chlorpromazine (thorazine)
thioxanthenes - thothixene (navane)
butyrophenones - heloperidol/droperidol (haldol)

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3
Q

3 s.e of phenothiazines

A

sedation
weight gain
TD

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4
Q

s.e of thioxanthenes

A

high potency ->
medium EPS
medium sedative
hypotension

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5
Q

s.e of butyrophenones

A

high potency ->
high EPS

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6
Q

which FGA is widely used and best for acute, short-term symptom control

A

butyrophenones (haldol)

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7
Q

first line option for schizophrenia

A

second gen (atypical) antipsychotics (SGA)

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8
Q

6 EPS

A

dystonia
akathisia
parkinsonism
TD
bradykinesia
tremors

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9
Q

continuous spasm and muscle contractions

A

dystonia

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10
Q

motor restlessness

A

akathisia

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11
Q

irregular, jerky movements

A

parkinsonism

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12
Q

involuntary muscle movements in the lower face and distal extremities

A

TD

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13
Q

slow movements

A

bradykinesia

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14
Q

why are SGA’s first line (3)

A

lower risk for:
EPS
TD
cognitive impairment

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15
Q

7 SGA/atypical antipsychotics

A

quetiapine (seroquel)
risperidone (resperdal)
ziprasidone (geodon)
paliperidone (invega)
aripriprazole
clozapin
olanzopine (zyprexa)

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16
Q

2 common s.e of SGA’s

A

weight gain
EPS

17
Q

which 2 SGAs are associated with less weight gain

A

apriprazole (abilify)
ziprasidone (geodon)

18
Q

which SGA is associated w. less EPS

A

risperidone (resperdal)

19
Q

which SGA causes the most weight gain

A

seroquel

20
Q

which SGA causes QT prolongation

A

ziprasidone (geodon)

21
Q

__ is an active metabolite of risperidone

A

palperidone (invega)

22
Q

which SGA is associated w. severe risk of neutropenia

A

clozopin

23
Q

which 2 SGAs are not recommended as first line tx

A

clozopin - reserved for refractory
olanzapine (zyprexa)

24
Q

you should start dosing for antipsychotics in __ for several weeks

after effective dose has been found, dosing should be __

A

divided daily doses
once daily

25
Q

antipsychotics are typically given during what time of the day

A

night

26
Q

3 pharm options for acute psychosis

A

zyprexa
haldol
benzos

27
Q

route of admin for zyprexa

A

IM
ODT

28
Q

route of admin for haldol

A

IV

29
Q

trials of SGA should last for at least __ at a therapeutic dose

A

6-8 weeks

30
Q

6 more serious s.e of SGA

A

hyperglycemia, DM, ketoacidosis
HLD
coma
death

31
Q

2 consideration when managing/distinguishing between drug induced psychosis and schizophrenia

A

give acute antipsychotic for pt evaluation

pt must be fully sober to gauge effectiveness of medication

Pharmacotherapeutics - Midterm (11 decks)

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