Schizophrenia Case Flashcards
8 clinical uses of antipsychotic agents
shizophrenia
bipolar
psychotic depression
senile psychosis
drug-induced psychosis
mood enhancement
anti anxiety
sleep disorders
3 first gen antipsychotics (FGA)
phenothiazines - chlorpromazine (thorazine)
thioxanthenes - thothixene (navane)
butyrophenones - heloperidol/droperidol (haldol)
3 s.e of phenothiazines
sedation
weight gain
TD
s.e of thioxanthenes
high potency ->
medium EPS
medium sedative
hypotension
s.e of butyrophenones
high potency ->
high EPS
which FGA is widely used and best for acute, short-term symptom control
butyrophenones (haldol)
first line option for schizophrenia
second gen (atypical) antipsychotics (SGA)
6 EPS
dystonia
akathisia
parkinsonism
TD
bradykinesia
tremors
continuous spasm and muscle contractions
dystonia
motor restlessness
akathisia
irregular, jerky movements
parkinsonism
involuntary muscle movements in the lower face and distal extremities
TD
slow movements
bradykinesia
why are SGA’s first line (3)
lower risk for:
EPS
TD
cognitive impairment
7 SGA/atypical antipsychotics
quetiapine (seroquel)
risperidone (resperdal)
ziprasidone (geodon)
paliperidone (invega)
aripriprazole
clozapin
olanzopine (zyprexa)
2 common s.e of SGA’s
weight gain
EPS
which 2 SGAs are associated with less weight gain
apriprazole (abilify)
ziprasidone (geodon)
which SGA is associated w. less EPS
risperidone (resperdal)
which SGA causes the most weight gain
seroquel
which SGA causes QT prolongation
ziprasidone (geodon)
__ is an active metabolite of risperidone
palperidone (invega)
which SGA is associated w. severe risk of neutropenia
clozopin
which 2 SGAs are not recommended as first line tx
clozopin - reserved for refractory
olanzapine (zyprexa)
you should start dosing for antipsychotics in __ for several weeks
after effective dose has been found, dosing should be __
divided daily doses
once daily
