Schizophrenia Flashcards
prevelence of schitzo, age of onset, gender difference, comorbity, cost
<1%
late teens to mid 30s
men get it earlier, women have later onset
substance abuse problems, personality disorders
costs are very high w hospitilization
3 active phase symptoms of schitzo
positive- displays of abnormal behaviour, delusions
disorganized- affect speech and behaviour
negative- (deficits) in speech, motivation
symptoms of schitzo
delusions
- -persecution (hes out to get me)
- -gandiose
- -ideas of reference (taking personal sig to enviroment)
Hallucinations
what area of the brain is more active with auditory hallucinations
Brocas area
how is speech affected with schitzo
-disorganized
loose association- switching from topic to topic
tangentiality- may ask q and get unrelated answer
incoherent- very hard to understand what person is sayin
how is behaviour affected w schitzo
lack of goal directed behaviour
catatonic symptoms
Negative symptoms of schitzo
flat affect- person does not show emotion
avolition- no initiative, no energy, lack of interest
alogia- vacent speech (y/n answers)
anhedonia- no pleasure
asociality- few friends
other symptoms of schitzo
inapropriate affect
low mood
switch sleep wake cycles
impairments w memory, slower processing speed
what do u need to be diagnosed w schitzo
at least one of: delusions hallucinations disorganized speech plus grossly disorganized negative symptoms social/occupational dysfunction
where the subtypes removed in dsm 5
yes
catatonia specifiers
Motoric immobility- adopting strange position
waxy flexibility- another person putting u in a weird pos
decreased engagement w others
excessive motor activity
echolalia- repatition of words
echopraxia- repatition of movements
further classification of schitzo
isidious vs acute
poor vs good premorbid
type 1: positive symptoms
type 2: negative symptoms
dopamine hypothesis
excess dopamine (D2 receptors)
evidence of dopamine hypothesis
- antagonists (neuroleptics) work
- Negative side effects of neuroleptics are similar to parkinsons
- amphetamines
evidence that its not the dopamine hypothesis
- dopamine antagonists dont always work
- dopamine blocked right away, but can take time for therapeutic effect
- dopamine antagonists work better on positive symptoms