Schizophrenia Flashcards
What did (Graham 1975) say about schizophrenia?
He discovered the inhibitory effects of the pre-pulse on the startle reflex in which a weak stimulus can suppress the startle response to a subsequent stronger startle stimulus.
Impairement in PPI is related to dysfunction in sensorimotor gating mechanisms
Increase in PPI means that you are atleast responding to the accustoming stimulus
Who said that reduced expression of parvalbumin containing interneurones correlates with a reduction in coordinated neural activity during task performance?
Lodge et al 2009
What does Lewis et al 2012 say?
People with schizophrenia exhibited lower activity of the dorsolateral prefrontal cortex and lower power of the frontal lobe gamma oscillations when performing tasks that require cognitive control. The gamma oscillations need strong inhibition of the pyramidal cell neurones which are provided by the parvalbumin basket cells that are dysfunctional in schizophrenia
What is Voss et al saying?
Schizophrenic patients lacked this predictive component of action awareness, showing a shift on ‘action only’ trials
