Schizophrenia Flashcards

1
Q

*What is schizophrenia?

A

Breakdown in the relation between thought, emotion and behaviour that leads to a faulty perception of reality

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2
Q

*Differentiate between positive and negative symptoms of schizophrenia

A

Positive symptoms (manifestations of psychosis):
-Delusions
-Hallucinations
-Disorganized thinking/speech/behaviour
“things that are there and shouldn’t be”

Negative symptoms:

  • Flat affect (affective blunting)
  • Anhedonia
  • Avolition
  • Alogia
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3
Q

Anhedonia =

Avolition =

Alogia?

A

= inability to feel pleasure

= is the decrease in the motivation to initiate and perform self-directed purposeful activities

= poverty of speech, is a general lack of additional, unprompted content seen in normal speech.

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4
Q

Diagnostic criteria for individual with schizophrenia?

LO

A

2 or more…
delusions, hallucinations, disorganized speech, grossly disorganized behaviour; catatonic behaviour; or negative symptoms
for significant portion of 1 month

1 or more…
major social or occupational reduction in functioning (such as work, interpersonal relations, self care)
Persisting for 6 months

Absence of major depressive or manic episode occurring at the same time with active symptoms

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5
Q

*Epidemiology for schizophrenia

When is most likely diagnosed?

A

Incidence and prevalence similar across cultures

“lowest social classes” and “homelessness” (cause or effect?)

Most are diagnosed in late adolescence or early adulthood
Males diagnosed earlier than females

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6
Q

Risk factors for Schizophrenia? (LO)

A

Perinatal stress
Parental age
Family history/genetics

50% have a comorbid medical condition
Substance abuse is common
Increase risk of diabetes? Cause or effect?
Distorted Water Balance

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7
Q

What is psychosis? (LO)

A

a severe mental disorder in which thought and emotions are so impaired that contact is lost with external reality.

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8
Q

*What are the 3 phases of first break psychosis?

A

Phase 1: Prodromal Period
person slowly losing social skills, not finishing work, behavior getting a bit odd…often seen in hindsight

Phase 2: Acute Phase (clear psychotic symptoms) - first break psychosis, acutely ill, POSITIVE symptoms arise; very vulnerable time, need speedy treatment for better prognosis (if stays in psychosis for long time, recovery is very hard)

Phase 3: Recovery Phase (pattern varies but probable)
teaching, hope, lifestyle, management

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9
Q

*Key components of treatment of first break schizophrenic episode

A
Antipsychotic medications (1-2 wks to take effect) 
Vigilant care (esp. until med effective)
Safety - Suicide assessment
Restore sleep
Reduce substance use 
Interdisciplinary
Psychosocial interventions
Education and support for client & family
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10
Q

*Schizophrenia treatment 3-5yrs afer onset?

A

Early Intervention Programs:

  • Reduce duration of untreated psychosis (DUP)
  • Intervene appropriately at early stage of illness
  • Prevent subsequent relapse & minimize disability

Treatment

  • Symptom relief with medication
  • Decreasing risk with safety measures
  • Family acceptance of client’s disease
  • Focus to stabilize symptoms
  • Understand/manage medication side effects

Stabilization and Maintenance:

  • Adapt/manage medications
  • Often intense treatment
  • Move beyond the illness and take control of their life
  • Live with chronic illness – continuous medication management & other psychotherapeutic activities
  • Adapt to chronic illness with family/caregiver
  • Socialization
  • Minimize stresses
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11
Q

*What is the concern with schizophrenia relapses?
What contributes to these relapses?
How does duration + recovery change with each relapse?

A

Major concern
Nonadherence
Vulnerable to stressors, lack of community resources
For each relapse, rehab time is prolonged, recovery time longer
Medication and psychosocial support required

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12
Q

*What sort of symptoms are you assessing for in individual with schizophrenia?
(what are the 3 most common/prominent?)

A

Delusions, hallucinations, disorganized behaviour (the big three)

Staying up all night, incoherent, irritable, aggressive acts
Unable to care for basic needs (eating, bathing); social and work functional deficits
Substance use; limiting social participation;
Cognitive deficits (patterns, executive function, short-term memory loss)

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13
Q

*Nursing diagnoses r/t schizophrenia?

A
Self-care deficit
Disturbed sleep pattern
Ineffective therapeutic regimen management
Imbalanced nutrition
Excess fluid volume
Sexual dysfunction
Risk of violence, suicide
Disturbed thought processes
Disturbed sensory perceptions
Disturbed body image
Low self-esteem
Disturbed personal identity
Ineffective coping
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14
Q

*Key nursing interventions for pt’s with schizophrenia

A

1) Promotion of self-care activities –> Develop routine of hygiene activities
2) Activity, exercise and nutritional interventions –> Help counteract effects of psychiatric medications
3) Thermoregulation interventions –> Teach patient to wear clothing according to the weather and seasons, Observe patient’s response to temperature.
4) Promotion of normal fluid balance and prevention of water intoxication
5) Self-monitoring and relapse prevention –> Monitor events, time, place, etc. of recurrence of symptoms
6) Enhancement of cognitive functioning –> Improve attention (computer programs, one-to-one); Help memory (make lists, write down information); Improve executive functioning-stimulation
7) Behavioural interventions –> Organize routine, daily activities, Reinforce positive behaviours
8) Stress and coping skills development –> Counselling sessions, Teach & reward positive coping skills
9) Patient education –>
Errorless learning environment, Minimal distractions, Clear visual aids, Skills training
10) Social support groups; community resources; support network

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15
Q

What sort of family interventions for pt with schizophrenia?

A

Family support
Educate family regarding lifelong disorder of schizophrenia
Emphasize consistency of medication
Encourage to participate in support groups
Inform re local community and provincial resources
Help negotiate provider system

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16
Q

*How should the disturbed thoughts of schizophrenia pt be seen?
What should a pt be taught regarding this?

A

Assessment content of hallucinations/ delusions
Outcomes
Decreased frequency and intensity
Recognize as symptoms of disorder
Develop strategies to manage recurrence
Experiences real to patient
Validate that experiences are real
Identify meaning and feeling that are provoked
Teach patient that hallucinations and delusions are symptoms of illness

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17
Q
  • Considerations for schizophrenia in children:

- How does it manifest?

A
  • Diagnosis rare in children
  • Manifestations similar to adults
  • Hallucinations visual, delusions less developed
  • Developmental abnormalities
    1) Delays in speech and motor development
    2) Problems in social adjustment
    3) Poorer academic performance
    4) Biopsychosocial symptoms as in adults
  • Other disorders considered first
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18
Q

1) Word salad:
2) Echolalia:
3) Clang associations:

A

1) seemingly random words and phrases
2) meaningless repetition of another person’s spoken words as a symptom of psychiatric disorder.
3) In psychology and psychiatry, clanging refers to a mode of speech characterized by association of words based upon sound rather than concepts. For example, this may include compulsive rhyming or alliteration without apparent logical connection between words.

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19
Q

1) Hyper-vigilance:

2) Pressured speech:

A

1) enhanced state of sensory sensitivity accompanied by an exaggerated intensity of behaviors whose purpose is to detect threats
2) Pressure of speech is a tendency to speak rapidly and frenziedly, as if motivated by an urgency not apparent to the listener.

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20
Q

WHat is first episode psychosis?

When does this typically occur?

A
  • first episode psychosis or initial episode of psychosis which is most common in adolescence or YA life.
  • This stage defined as the first 3-5yrs following onset of symptoms
  • critical time for intervention
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21
Q

How are prodromal symptoms often seen?

A

may be subtle, often begin in late adolescence and can be confused w moodiness of teenage yrs

• Changes in thought and behaviour eventually so disruptive/bizarre they cant be ignored (this heralds the beginning of psychosis)

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22
Q

What trends will you see if length of duration of untreated psychosis (DUP) is prolonged?

A

dec self-care, eating, sleeping, substance use common, work/school fx dec, inc dependence on family and friends

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23
Q

High risk of what during acute phase psychosis?

A

suicide

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24
Q

Focus of initial tx of schizophrenia/

A

thorough assessment and alleviation of symptoms through:

  • beginning meds
  • dec risk for suicide by safety meas
  • normalizing sleep
  • dec substance use
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25
Q

What occurs during the stabilization period of treatment?

Maintenance and recovery period?

A
  • After dx and start of tx theres focus on stabilizing symptoms (which are now less acute but can be present still)
  • Family adjusts to mental illness (w help)
  • Socialization and rehabilitation begin
  • Intense tx at this stage

• After stable the focus is regaining fx and improving QOL
• Faithful med mgmt is nec
• Family support and involvement are important (educating family is key… on disease, s/s of relapse etc)
o During recovery pts need help accepting illness and hope for future
o Need help to avoid isolation nurses can improve social skills/vocational skills and alt living arrangements to ensure contact with others

26
Q

Relapse
Likely?
Generally what is the cause?
What occurs with each subsequent relapse with regard to length of recovery?
What approach is best to dec severity + freq of relapse?

A
  • Not inevitable but can occur at any time
  • Gen d/t nonadherence-d/cing meds almost certain to lead to relapse and W each subseq relapse the rehab is prolonged and longer recovery time
  • Combining meds and psychosoc tx dec the severity and freq of relapses
  • Have a realistic, hopeful attitude
27
Q

DSM criteria for schizophrenia?

A
  • According to DSM schizophrenia is mixture of positive and negative symptoms that present for significant portion of 1 month period: ( delusions, hallucinations, disorganized speech, grossly disorganized or catatonic behaviour) and negative symptoms (at least one of delusions, hallucinations or disorganized speech must be present)
  • Disturbance in level of fx for 1 or more major areas of social or occupational fx markedly below previous level eg self-care, interpersonal relationships etc
  • with continuous signs of disturbance persisting for min 6months
  • Absence or insignificant duration of major depressive, manic, or mixed episodes occurring concurrentl w active symptoms
28
Q

Do we use “paranoid schizophrenic” and other subgroupings now?

A

• The previous subtyping eg paranoid schizo, catatonic schizo etc weren’t helpful are no longer used much

29
Q

Is schizophrenia seen to be a direct physiologic effect of substance or medical condition?

A

No.

30
Q

target symptoms of schizo?

Associated findings

A

inapprop affect, l/o interest or pleasure, dysphoric mood (anger, anxiety, depression), disturbed sleep pattern.

Associated findings: lack of interest in eating/refusing food, diff concentrating, some cog dysfx (eg confusion, disorientation, and memory impairment), lack of insight, depersonalization, derealisation, somatic concerns, motor abn

31
Q

Findings of physical exam for schizo pt?

Assoc lab findings?

A

physically awkward, poor coordination or mirroring, motor abn, cigarette related pathologies (pulm/cardiac issues)

slowed rxn times, abn eye tracking, inc size of basal ganglia, dec temporal and hippocampal size, enlarged ventricular system and prominent sulci in brain cortex

32
Q

What are the different kinds of delusions?

A

o Grandiose: belief that one has exceptional wealth, skill, influence, destiny, power
o Nihilistic: belief that ones dead or calamity is impending
o Persecutory: belief that ones being watched, ridiculed, harmed, plotted against
o Somatic: beliefs about abn in bodiy str or fx

33
Q

What kind of neurocognitive impairment is seen?

A

Many areas can be affected eg ST memory, planning, self-monitoring, verbal fluency etc etc
o Intellectual fx and LT memory not nec affected
o Can be independent of positive and negative symptoms

  • OFten seen as disorganized thinking
34
Q

What kind of disorganized behavior is seen?

A

o May mnfest as slow rhythmic movement, coupled with disorganized speech
o Aggression
o Agitation-inability to sit still/attend to others
o Catatonic excitement-
o Echopraxia-
o Regressed behaviour-like child, immature
o Stereotypy-
o Waxy flexibility-

35
Q

What is catatonia

A

…from internet
abnormality of movement and behavior arising from a disturbed mental state (typically schizophrenia). It may involve repetitive or purposeless overactivity, or catalepsy, resistance to passive movement, and negativism.

36
Q

Waxy flexibility?

A

posture held in odd or unusual fixed position for extended period

37
Q

Stereotypy-

A

repetitive, purposeless movements that are idiosyncratic to indiv and to some degree outside of indiv control

38
Q

Echopraxia?

A

invol imitation of another persons movements and gestures

39
Q

Catatonic excitemnt?

A

hyperactivity char by purposeless activities and abn movements like grimacing and posturing

40
Q

Risks factors for schiz?

A

o Stresses in perinatal period
o Obstetrical complications
o Genetic and family susceptibilities.
o Parental age
o Urban settings have inc risk
o Infants affected by maternal stressors may have conditions that create their own risk eg low birth wt, short gestation, and early dev diff
o stressors may include CNS infect during childhood

41
Q

How is estrogen tied to schiz?

A

Estrogen may be protective

Men typically dx earlier.

42
Q

Comorbidities and schiz?

is this common?

A

o Almost 50% of those w schizo have other medical condition but its often mis/undiagnosed

  • substance abuse and depression
  • DM
  • Disordered water balance
43
Q

Relationship bt schizo + DM?

A

o Theres assoc between glucose reg and psych disorders
o Previously used to use insulin shock therapy for severe disorders
o Schiz pts are prone to type II DM at 2-3x rate of gen pop
o DM can exacerbate cog deficits in those w schiz

44
Q

Cannabis + schizo?

A

o cannabis is assoc w inc risk of psychosis onset

45
Q

Suicide rate in schizo pt’s?

A

10% - important in consideration of importance of depression as comorbidity with schizo

o 20-50% of people with dx attempt suicide and 10% commit suicide as result of psychosis in acute stages or in response to depression in chronic phase

46
Q

o disordered water balance and schizo?

A

o more common with early onset schiz
o often takes form o water intoxication char by abn high water intake, followed by rapid drop in serum sodium levels (which leads to neuro signs and can lead to ataxia, coma, death)
o cause unknown but pts compulsively drink. Can be up to 10L day…may drink from toilet etc..
o sodium can fal below 120mEq/L (acute hypotnatremia)→risk of seizures etc as above

47
Q

Why is dopamine thought to be implicated as cause of schiz?

A

o Dopamine hypothesis arose because antipsychotic drugs successfully dec positive symtoms. Also, other drugs that inc dopamine fx like cocaine and amphetmaines cause bahv symptoms like schiz. D/t this researches thought schiz ws syndrome of hyperdopaminergic action. This isn’t the whole truth though, now complicated by new findings.

o Positive symptoms are thought to be caused by dopamine hyperactivity in mesolimbic tract which reg memory and emotion
o Negative symptoms and cog impairment arise from hypoactivity of dopamine in mesocortical tract r/t motivation, planning, attention, socialness

o Schiz doesn’t arise from dysregulation of single NTM eg NE, serotoning, dopamine…also involved are glutamate and GABA

48
Q

What is seen in PET scans of those with schiz? (r/t metb)

A

o PET scans suggest gen dec metb in brain of schiz pt with some hypermetb in certain areas. Also shows hypofrontality or dec cerebral blood flow and gucose metb in PFC and hyperactivity in limbic system

49
Q

How might families respond to schizo dianosis + illness? How should nurses respond?

A

o May look for reasons (drugs?) may blame selves (parents)
o Family are often primary caregivers for ill relative
- May be angry, overwhlemed, depressed
o Help family not to blame selves, hold hope, and EDUCATE THEM

50
Q

What kind of biologic assessments to comlpete?

A

o Pmhx, px: to rule out illness or substance abuse
o Look for comorbid illness (DM, HTN, cardiac disease or fam hx of these issues)
o People w schiz have inc mortality rate from physical illness and often have smoking related illness. Smoking can also interfere w med clearance
o Info about physical fx (self-care and sleep may be best collected from fam)
o Prioritize the current issue (if hallucinations are impairing fx then meds are necessary immed if not then coping with neg symptoms is priority)
o Nutritional hx
o Assess fluid balance for polydipsia, water intoxication, polyuria, hyponatremia, hypervolemia. Daily wt?
o Ideally do assessments before starting meds, look for abn motor movemnt. Assess side effects of med

51
Q

What sort of biologic nursing diagnoses?

A

o Focus on self care deficit and disturbed sleep pattern
o During relapse: ineffective therapeutic regimen mgmt, imbalanced nutrition, excess fluid volume sexual dysfx. May be constipated if taking anticholinergics

52
Q

Interventions for biologic domain?

A

o Promotion of self care activities (diff d/t neg symptoms like avolition). Routine is helpful.
- acitivity exercise and nturitonal interventions—nec to counteract wt gain from meds.
o Thermoregulation intervention
o Pharm interventions/monitoring and admin meds
o monitoring extrapyrimidal side effects

53
Q

Why are activity/nutritional interventions important?

A

nec to counteract wt gain from meds. When psychotic the pt cant focus on eating then when on meds they overeat. Wt gain→nonadherence to meds and DM II. Take BP regularly. Monitor BG, cholesterol, triglycerides.

54
Q
What are the drugs of choice for schizo/
How long to kick in ?
How long should pt give drug trial before switching? 
How long are they typically on these?
Risk of coming off quickly?
A

antipsychotics are tx of choice for psychotic pt, they typically ake 1-2 wks to change symptoms. Pt should remain on drug 6-12wks to give proper trial before switching (we d/c pts before getting to see if their meds are working).
o Pts often remain on their meds for life
o immed cessation of meds if pt develops=neuroleptic malignant syndrome or agranulocytosis

55
Q

How do extrapyramidal side effects of antipsychotic meds manifest?
How to manage them?

A

: looks exactly like parkinsons, tend to occur in o adults. d/t blocked dopamine receptors in basal ganglia which skews balance of Ach and dopamine.
- “Dystonic rxns” - body contortions, uncontrolled eye movements etc.
- Akathisia: restlessness
o Symptoms are managed by dec dose or adding anticholinergic drug. Don’t abruptly stop this!

56
Q

Other Side effects of antipsychotics

A

o Orthostatic HoTN is d/t antiadrenergic effects.
o Hyperprolactinemia, gynecomastia, galactorrhea, menstrual irreg, sexual dysfx
o Wt gain may be as high as 20-30lbs in yr
o Sedation is side effect
o DM is linked to atypical antispychotics
o Dysrhythmias are risk
o Agranuloctyosis-may have precipitous drops in WBCs-investigate infections and take blood counts immed

57
Q

Components of psychological assessment?

A

o Response to mental health problems-pts struggle to control symptoms that affect eveyr aspect of life.
o Mental status and appearance—eccentric, poor hygiene, weird dress, posture suggests lethargy or stupor
o Mood and affect—affect is on a continuum flat-blunted-full range.
o Speech—may reflect obsessions, delusions, pressured thinking, loose assoc or flight of ideas and neologisms.
o Thought processes and delusions
o Hallucination
o Disorganized communication
o Cog impairments
o Memory and orientation
o Insight and judgement
o Self concept—usually poor (stigma, body image)
o Stress and coping patterns
o Risk assessment

58
Q

Psychological related nursing diagnoses?

A

disturbed thought processes, disturbed sensory perception, disturbed body image, ineffective coping, low self esteem, disturbed personal identity

59
Q

How to assess hallucinations?

A

o Most wont voluntarily share their hallucinatory exp w interviewer and nurse might have to rely on indirect evidence in pts behaviour like 1) pauses in convo when pt seems preoccupied or is listening to someone other than interviewer 2)looking to perceived source of voice 3) responding t the voices in some way

60
Q

Cognitive impairment assessments?

A

varies widely bet pts. If impairment suspected they may need psychologist
o sustained inc in attention may be present (hypervigilance).
o May have dec ability to focus on relevant stimuli
o May not recog familiar stimuli
o Dec info processing→illogical/inapprop conclusions
o Diff to assess just from clinical assessment, may need MMSE or other screen.