IBD - TEXT Flashcards
What country has highest IBD rates in the world
Canada
When is IBD most common?
What other trends/risks are seen?
- Most common in 15-30yrs, then 50-70yrs
- High risk r/t family hx (largest independent risk factor for IBD)
- Equal in men and women; prevalent in Jewish individuals
- Cause unknown – triggered by environmental factors such as pesticides, food additives, tobacco, and radiation; allergies and immune disorders suggested as causes as well
What classification of drugs exacerbate IBD?
NSAIDs
When is crohns often diagnosed?
in adolescents and young adults
According to Day et al, what layers of the GI tract are affected by Crohn’s?
extends through all layers
Crohn’s area of GI most affected?
o Changes most common in distal ileum and ascending colon
Do you see exacerbations and remissions characteristically in Crohns?
Yes
this is also said to be true of UC…thought it was more a thing in UC?
How does the bowel change with Crohn’s initially?
How/why does lumen size change overall?
o Begins with edema and thickening of mucosa, ulcer begins to appear in inflamed mucosa
o Intestinal lumen narrows as bowel wall thickens
How are the lesions described in Crohn’s?
Lesions not continuous, occur in “cobblestone” clusters
What complication is common in Crohns?
o Fistulas, fissures, and abscesses form as inflm extends into peritoneum
50% have granulomas
What type of onset is seen in Crohns?
Insidious
Where is pain seen in Crohns?
Characteristic of diarrhea in this condition?
lower right quadrant abdominal pain
diarrhea unrelieved by defecation
Why are crampy pains seen in Crohns?
Scar tissue and granulomas obsruct lumen so contents can’t pass properly, resulting in crampy abdominal pains
Why does anemia result form Crohns?
Not eating
and probably some minimal blood loss?
In which kind of IBD do you seen intestinal weeping?
Crohn’s
What occurs with perforation of lesions in Crohns?
intrabdominal and anal abscesses → Fever and leukocytosis
Manifestations of Crohn’s in other systems?
joint disorders, skin lesions, ocular disorders, oral ulcers
What characteristic of stool is seen in Crohns?
Steatorrhea