Schizophrenia Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

Diagnostic Criteria: schizo definition

A
  • psychotic disorder ( pacients lose contact with reality),
  • hard to tell difference between real and imagined experiences
  • most lack insight into their condition
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Diagnostic Criteria

A
  • must show at least one of the symptoms for at least one month
  • 2 symptoms necessary in less clear cut cases
  • other potential causes for symptoms must be eliminated before diagnosis (medication side effects, brain tumour, substance misuse)

-prodromal symptoms: weaker versions of the core symptomps, typically shown before diagnosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Diagnostic Criteria: Age of Onset

A

-males: usually earlier (earlier to mid 20)
-females: late 20’s
-late onset (40+) more common in females
-prevalence similar male&female (o.3 -o.7)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Positive vs negative symptoms

A

Positive symptoms - the presence of psychological abnormality

negative sympotms - the absence of behaviours that we consider psychollogically normal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

+ Hallucinations

A

involuntary perceptual experiences that happen in the absence of external stimuli
- visual, olfactory, somatosensory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

+ Influence, passivity or control - 3 eg

A

the subjective experience that our thoughts, feelings and actions are controlled by external forces

  • thought withdrawal: feeling that thoughts are being removed
  • thought insertion: feeling that thoughts are being implanted
  • thought broadcasting: feeling that their thoughts are being transmitted to others
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

+ Delusions

A

fixed beliefs that conflict with reality

  • grandeur: may see themselves as exceptional (superhuman powers)

-persecution: belief others want to harm them or they are being spied on, or tricked

-reference: belief random situations have personal significance (its a sign)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

+ Other Positive Symptoms

A

-disorganised thinking
-incoherent speech
-unexpected gestures and posture

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

negative sympotms - list and def

A

avolition- inability to carry out goal driven behaviour

alogia- lack of spoken language

anhedonia- inability to experience pleasure

asociality- social withdrawal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

About Aneja

A
  • case study of a boy from a troubled home and aggressive father, divorced parents and living with grandparents
  • hearing teasing voices, spoke to unseen others, spoke very little, lack of insight into his condition, asocial

-given sodium valporate - behaviour improved at first but worsened again and he was admitted in hospital for own safety

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Aneja Evaluation 1+ 1-

A

+ detailed case history - increases validity of diagnosis

  • not generisable to other cultures - took place in india where there is stigma - might have worsened condition
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Freeman: aim and hypothesis

A

To find out whether neutral non-threatening avatars could provoke persecutory thoughts in people with no previous clinical diagnoses.

And whether this was more common in people with higher levels of paranoia and emotional distress

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Freeman: methodology

A

correlational study

quantitative data - questionnaires

qualitative data - semi-structured interviews

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Freeman: sample

A

volunteer sampling
12 male 12 women
mean age: 26
UCL
mentally well
21 students, 3 staff

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Freeman: procedure

A
  1. trained in how to use VR
  2. half completed BSI, Spielberger State Anxiety Questionnaire, Paranoia Scale
  3. all completed vr task
  4. 5 avatars sat in 2 small groups in a library, talking to eachother, sometimes smiling
  5. Were asked: Explore the room and try to form some impression of what you think about the people in the room and what they think about you.
  6. All completed the 3 questionnaires plus a new one - VR Paranoia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Freeman: questionnaires -4

A

Brief Symptom Inventory - 53 item questionnaire to asses mood in past 7 days
Paranoia Scale - 20 item, measures ideas of persecution and reference
Spielberger State Anxiety Questionnaire - 20 item, measures current state
VR - Paranoia Scale: 15 item

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Freeman: results - 4 correlations, 2 comments, level of agreement to statements

A

Persecutory thoughts + positively correlated with ideas of reference
Persecutory thoughts - negatively correlated with positive beliefs
Persecutory thoughts in the questionnaire + positively correlated with persecutory thoughts in the interview the interviews
VR Persecutory ideation + positively correlated with paranoia, interpersonal sensitivity and anxiety, all
measured using the BSI

Comments from the semi-structured interviews:
- Positive: people were nicer than real people
-Negative: They were telling me to go away

Someone in the room had it in for me - most disagreed
They were talking about me behind my
back - a bit more agreed
They were friendly towards me - most agreed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Freeman: conclusion

A

Emotional processes linked to anxiety and interpersonal sensitivity contribute directly to the development
of persecutory ideation

VR holds ‘great promise’ not only as a tool for enhancing theoretical understanding but also as a way of helping individuals to evaluate and reduce persecutory ideation and delusions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Freeman: ethics

A
  • all gave consent
  • levels of anxiety were relatively the same before and after VR
  • Freeman checked to see if time in VR created any distress in interviews - not the case
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Freeman: Two strengths, 2 Weaknesses

A

+ half the participants answered BSI, paranoia,, and anxiety questionnaires - to see if there were any demand characteristics

+ both nomothetic and ideographic - qualitative - idiographic, quantitative - nomothetic

  • sampling bias - all from UCL -not generalisable
  • participants reported low level of presence in VR - LOW ECOLOGICAL VALIDITY
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Freeman: Issues and debates

A
  • both nomothetic and ideographic - qualitative - idiographic, quantitative - nomotheti
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Genetic Explanation: Classic Research - twin studies

A

Concordance Rate:
MZ Twins - 42%
DZ Twins - 9%
strong argument for heritability - but not fully

23
Q

Genetic Explanation: Contemporary Research

A

GWAS Studies:

polymorphic genes- genes with different alleles

schizo is polygenic- thousands of gene variants are related to scizophrenia

24
Q

Genetic Explanation: DiGeorge syndrome

A

a strand of DNA with 30-40 genes is deleted from chromosome 22
1/4 people with it develop schizophrenia vs 1/100 without it
- linked to the deletion of the COMT gene

25
Q

Genetic Explanation: COMT Gene

A

-gene codes for an enzyme which breaks down dopamine neurotransmitter

26
Q

Genetic Explanation: DISC 1 Gene and GABA neurotransmitter

A

Disrupted in schzophrenia gene related to the GABA neurotrannsmitter

GABA - inhinitory neurotransmitter which helps to regulate activity in neural circuits that communicate via dopamine and glutamate

irregularity in DISC1 - increase vulnerability in excess dopaminergic activity and therefore symptoms of schizophrenia

27
Q

Genetic Explanation: Strenght Met and Val

A

+supported by research evidence

2 types of COMT Gene : Met and VAL

Val - decreased dopamine acivity - elevated risk of schizophrenia

-> suppports dopamine deficiency hypothesis& genetic explanation

28
Q

Genetic Explanation: Nature. vs nurture

A

although Twin studies prove the nature side, validity questionable

  • it is also nurture: MZ twins same gender, more likely same treatment, same rules
29
Q

Genetic Explanation: reductionism vs holism

A
  • overly reductionist - it is possible to train ourselves to how we react and interpret information
30
Q

Biochemical Explanation: Excess dopamine

A

cause: excess in L-dopa, overactive synapses that use dopamine, differences in the number of receptors on the postsynaptic cell

31
Q

Biochemical Explanation: Dopamine deficiency

A
32
Q

Biochemical Explanation: nature vs nurture

A
33
Q

Biochemical Explanation: reductionism holism

A
34
Q

Biochemical Explanation: determinism and free will

A
35
Q

Psychological Explanation: errors in self monitoring

A
36
Q

Psychological Explanation: difficulties with mentalising

A
37
Q

Psychological Explanation: thinking errors and biases

A
38
Q

Psychological Explanation: strengths and weaknesses

A
39
Q

Psychological Explanation: individual and situational

A
40
Q

Psychological Explanation: idiographic vs nomothetic

A
41
Q

Biological TREATMENT - types

A
42
Q

Biological TREATMENT: typical antipsychotics

A
43
Q

Biological TREATMENT: Atypical antypsychotics

A
44
Q

Biological TREATMENT: The Texas Medication Algorithm Project

A
45
Q

Biological TREATMENT: strengths and weaknesses

A
46
Q

Biological TREATMENT: Electroconvulsive therapy (ECT)

A
47
Q

Biological TREATMENT: ECT Issues and debates 3

A
48
Q

Psychological treatment - CBT

A
49
Q

CBT - Exploring events, beliefs and feelings

A
50
Q

CBT - Preventing relapse through stress management

A
51
Q

CBT - Psychoeducation

A
52
Q

Psychological treatment: Evaluation

A
53
Q

About Sensky

A
54
Q

Sensky Evaluation

A