Schizophrenia Flashcards
What are the two classifications of schizophrenia?
DSM-5 and ICD-10
What does the DSM-5 require for diagnosis?
One positive symptom must be present for diagnosis
What does the ICD-10 require for diagnosis?
Two negative symptoms must be present for diagnosis
What are the positive symptoms of schizophrenia?
Hallucinations and delusions, disorganised speech
What are the negative symptoms of schizophrenia
Speech poverty and Avolition
Give two strengths of diagnosis and classification of schizophrenia
- Inter-rater reliability (Osorio +97 using the DSM-5)
- Test- retest reliability (Osorio +92 using the DSM-5)
Give 3 brief limitations of the diagnosis and classification of schizophrenia
- Co- Morbidity & symptom overlap= schizophrenia is consistently diagnosed with other disorders e.g depression
- Culture bias = symptoms such as hearing voices is positive in other cultures. afro Caribbean
- Gender bias = Women are under diagnosed as they have closer relationships with others (able to function)
What does Gottesman’s scale read?
Identical twins = 48%
Fraternal twins = 17%
Children = 13%
Siblings = 9%
Parents & half siblings = 6%
Grandchildren = 5%
Nephews & Nieces = 4%
Uncles & Aunts = 2%
Cousins = 2%
General population = 1%
What does Gottesman’s scale prove?
Proves a correlation between genes and schizophrenia as the stronger the genes are the higher risk is.
What do candidate genes mean?
The genes involved in schizophrenia
What does polygenic mean?
Schizophrenia is influenced by many genes
What are the most likely genes of schizophrenia
The ones coding for neurotransmitters
Who found genetic variations in schizophrenia and how many were there?
Ripke et al: found 108 separate variations were invoked in the risk of schizophrenia by studying people with schizophrenia and a control group
What term describes many different combinations of factors can lead to schizophrenia?
Aetiologically heterogeneous
Give one strength of the genetic explanation of schizophrenia
Research support = Gottesman
What is a limitation of the genetic explanation of schizophrenia?
Nature v nurture = the fact the concordance rates on Gottesman’s chart aren’t 100% means schizophrenia cannot wholly be explained by genes
What are neural correlates in reference to schizophrenia
activity in the brain that occur in correlation to schizophrenia
What is the main neural correlate for schizophrenia?
The neurotransmitter dopamine
What is the original dopamine hypothesis?
Based on the discovery that drugs used to treat schizophrenia that reduced dopamine also reduced symptoms
-suggesting schizophrenia is linked to high levels of dopamine
How can dopamine be an explanation for speech poverty?
An excess of dopamine receptors in pathways from the sub cortex to Broca’s area
What is the updated version of the dopamine hypothesis?
Try to explain the orgins of abnormal dopamine function
What is the research for the updated dopamine hypothesis?
Howes = genetic variations and early experiences of stress make some people more sensitive to hyperdopaminergia (higher than usual levels of dopamine in the sub cortex)
Give one strength of neural correlates of schizophrenia
Evidence for dopamine = support for the idea that dopamine is involved in schizophrenia. Antipsychotic drugs reduce dopamine activity and also symptoms
Give one limitation of neural correlate of schizophrenia?
Biologically reductionist = just because someone has high Dopamine levels doesn’t mean they will have schizophrenia