Schizophrenia Flashcards

1
Q

Psychosis Terminology:

Positive Sxs

A

Atypical excesses (not a part of normal experience) i.e. hallucinations, delusions, etc.

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2
Q

Psychosis Terminology:

Negative Sxs

A

Absence of normally occurring behaviors, i.e. lack of speech (alogia, amotivation, asociality) etc.

Up to 60% of those with Schizophrenia have strong neg. Sxs.

Neg. Sxs are frequently first Sx of illness.

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3
Q

Psychosis Terminology:

Hallucinations

A

Perception not based on external stimuli

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4
Q

Psychosis Terminology:

Illusion

A

Misperception of an external stimuli

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5
Q

Psychosis Terminology:

Delusion

A

False belief maintained despite strong evidence to the contrary

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6
Q

Psychosis Terminology:
Delusions can either be:
______ or _______

A

Bizarre - can never possibly occur

Non-bizarre - could potentially occur (but aren’t occurring now)

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7
Q

Psychosis Terminology:
Specific types of delusions:
Ideas of reference

A

Incorrectly believe external events are occurring for or with specific reference to oneself

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8
Q

Psychosis Terminology:
Specific types of delusions:
Thought broadcasting

A

Delusion that one’s thoughts are being broadcast out loud for others to hear

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9
Q

Psychosis Terminology:
Specific types of delusions:
Thought insertion

A

Delusion that some of one’s thoughts have been inserted in one’s mind by others

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10
Q

Psychosis Terminology:

Loose associations/derailment

A

Person’s ideas slip from one topic to another - at best obliquely related to one another

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11
Q

Psychosis Terminology:

Neologism

A

a made-up word used by the person

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12
Q

Psychosis Terminology:

Clanging

A

words are strung together based on sound similarity (vs. meaning)

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13
Q

Psychosis Terminology:

Word salad/Incoherence

A

a mixture of words and phrases that lack logical coherence

this disturbance occurs within clauses, whereas with loose associations is between clauses

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14
Q

Psychosis Terminology:

Poverty of content

A

person speaks but conveys little content

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15
Q

Psychosis Terminology:
Negative Sxs: Referred to as the A’s (Bleuler’s terminology)
Alogia

A

impoverished speech and thought

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16
Q

Psychosis Terminology:
Negative Sxs: Referred to as the A’s (Bleuler’s terminology)
Avolition

A

inability to initiate and persist in goal-directed activities

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17
Q

Psychosis Terminology:
Negative Sxs: Referred to as the A’s (Bleuler’s terminology)
Affect

A

refers to emotions

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18
Q

Psychosis Terminology:
Negative Sxs: Referred to as the A’s (Bleuler’s terminology)
Blunted affect

A

affective expression is reduced in intensity

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19
Q

Psychosis Terminology:
Negative Sxs: Referred to as the A’s (Bleuler’s terminology)
Flat affect

A

an absence of affective expression

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20
Q

Psychosis Terminology:
Negative Sxs: Referred to as the A’s (Bleuler’s terminology)
Inappropriate affect

A

affective content does not match the situation or content of what is being said

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21
Q

Psychosis Terminology:
Negative Sxs: Referred to as the A’s (Bleuler’s terminology)
Anhedonia

A

inability to experience pleasure from activities that usually produce pleasurable feelings

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22
Q

Schizophrenia Course:

Prodromal phase

A

the period leading up to the full blown Dx characterized by increase in Sxs and increase in adjustment problems

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23
Q

Schizophrenia Course:

Residual

A

phase of the illness after remission of the florid active Sxs

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24
Q

Schizophrenia - DSM-5 Diagnostics:
A. More than 2 Sxs each present for a significant portion of time during a 1 month period (less if successfully treated). (Most crucial criteria)

5 Domains

A

At least 1 of which must be (1), (2), or (3).

  1. Delusions
  2. Hallucinations
  3. Disorganized speech
    (freq. derailment or incoherence)
  4. Grossly disorganized or catatonic behavior
  5. Negative Sxs
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25
Q

Schizophrenia - DSM-5 Diagnostics:
B. For a significant portion of time since onset, level of functioning in more than 2 major areas (e.g., work, interpersonal, self-care) is markedly ________ prior to onset.

A

below level

if onset during childhood there is a failure to achieve expected levels of functioning

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26
Q

Schizophrenia - DSM-5 Diagnostics:

C. Continuous signs persist for _____

A

more than 6 months

The 6 months MUST include at least 1 month of active Sxs (less if actively treated) (active = meets criteria A)

AND

Rest of time may be prodromal or residual

Note: during prodromal or residual phase, disturbance may be manifested only as -
1. negative Sxs
OR
2. more than 2 criteria A Sxs present in an attenuated form (odd beliefs vs. delusions)

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27
Q

Schizophrenia - DSM-5 Diagnostics:

D. Schizoaffective Dx and Depressed or Bipolar Dxs with psychotic features have been ruled out b/c…

A

No major depressive or manic episodes during acute phase

OR

If mood episodes occur during active phase, they represent only a minor to total duration of the active and residual periods of the Dx.

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28
Q

Schizophrenia - DSM-5 Diagnostics:

E. Disturbance not attributable to ______ or other ________

A

substance or other medical condition

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29
Q

Schizophrenia - DSM-5 Diagnostics:

F. If Hx of ASD or a Communication Dx with childhood onset, additional Dx of schizophrenia ONLY MADE IF….

A

Prominent hallucinations or delusions, in addition to other required Sxs of schizophrenia are also present for more than 1 month (or less if successfully treated)

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30
Q

Schizophrenia - DSM-5 Specifiers:
Hx specifiers:
Episodes
Remissions

A
  • first episode
  • multiple episodes
  • continuous
  • acute = Sx criteria fulfilled
  • full or partial remission
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31
Q

Schizophrenia - DSM-5 Specifiers:
Catatonia specifier:
Reactivity to environment

A

-Marked decrease in reactivity to the environment

present in several Dxs - psychotic, mood, and ASD

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32
Q
Schizophrenia - DSM-5 Specifiers:
Catatonia specifier: 
Extreme reactions 
S/M
A
A

stupor/mutism or agitation

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33
Q
Schizophrenia - DSM-5 Specifiers:
Catatonia specifier:
Repetitive behaviors
E
E
S
S
A
  • echolalia (repeating speech)
  • echopraxia (repeating actions)
  • staring
  • stereotypies (repeated motor behaviors with no goal)
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34
Q

Schizophrenia - DSM-5 Specifiers:
Catatonia specifier:
Behaviors that don’t mach the situation

A
  • mannerisms

- grimaces

35
Q

Schizophrenia - DSM-5 Specifiers:
Catatonia specifier:
Motoric

A
  • posturing
  • catalepsy (maintains a posture against gravity then slowly sinks back into resting state
  • waxy flexibility (maintains posture against gravity and resists repositioning)
  • negativism (resistant to direction)
36
Q
Schizophrenia - Associated Sxs:
Often present
1. \_\_\_\_\_\_\_\_
2. \_\_\_\_\_\_\_\_
3. \_\_\_\_\_\_\_\_
A
  1. Before psychotic Sxs appear
  2. During remission
  3. Seen in 1st degree relatives
37
Q
Schizophrenia - Associated Sxs:
Cognitive Sxs:
Overall mental task deficits in...
1.\_\_\_\_\_\_\_
2.\_\_\_\_\_\_
3. \_\_\_\_\_\_
4.\_\_\_\_\_\_
5.\_\_\_\_\_\_
A
  1. Attention
  2. Decreased processing speed (verbal tasks, visual stimuli)
  3. Decreased Verbal memory
  4. Decreased EF skills
  5. Decreased reasoning
38
Q
Schizophrenia - Associated Sxs:
Social Cognition Sxs:
1. \_\_\_\_\_\_
2. \_\_\_\_\_\_
3. \_\_\_\_\_\_
A
  1. Emotional recognition
  2. Social problem solving
  3. Theory of the mind (putting self in other’s shoes - recognizing that others have a mind as well)
39
Q
Schizophrenia - Associated Sxs:
Motor Sxs:
1.\_\_\_\_\_\_
2.\_\_\_\_\_\_
3.\_\_\_\_\_\_
4.\_\_\_\_\_\_
A
  1. Early motor milestones (e.g., walking)
  2. Gesturing
  3. Sensory integration
  4. Motor planning and sequencing
40
Q

Schizophrenia Onset:
Late _____/early _____ for males (family of origin might pull child back)

Mid ____ to early _____ for females (implications for later onset - might have two support systems - family of origin and family of marriage)

A

teens; 20s for males

mid 20s; early 30s for females

41
Q
Schizophrenia 
Other sex differences:
Females MORE likely to...
1. \_\_\_\_\_\_\_\_
2. \_\_\_\_\_\_\_
A
  1. Be married

2. Have an affective component

42
Q

Schizophrenia
Other sex differences:
Females are LESS likely to…
1. ______

A
  1. Have a Sx profile noteworthy for strong negative Sxs

Negative Sxs are associated with poorer outcome than positive Sxs

43
Q

Schizophrenia
Prognosis:
A poorer prognosis is associated with…
1. Early _____

A

onset

44
Q

Schizophrenia
Prognosis:
A poorer prognosis is associated with…

  1. Gradual _____
A

onset/poor premorbid functioning

45
Q

Schizophrenia
Prognosis:
A poorer prognosis is associated with…

  1. ______ sex
A

the male

46
Q

Schizophrenia
Prognosis:
A poorer prognosis is associated with…

  1. _____ Hx of Sz.
A

Family Hx

47
Q

Schizophrenia
Prognosis:
A poorer prognosis is associated with…

  1. High levels of ______ _____ in family members with whom the client resides
  • Increased _____ over-involvement
  • Increased ______
A

expressed emotion;

increased emotional over-involvement;

increased hostility

48
Q

Schizophrenia
Course:
Incidence of Sz. is ________ in different countries

A

the same

49
Q

Schizophrenia
Course:
The course was _____ in developing (vs. developed) countries

A

better

50
Q

Schizophrenia
Course Cultural Differences:
Cultures _____ in how they deal with Dxs

A

vary

51
Q

Schizophrenia
Course Cultural Differences:
Closer links between ____ and _____ (may normalize behaviors)

A

Sxs; cultural/religious practices

52
Q

Schizophrenia
Course Cultural Differences:
Stigma levels _____

A

vary

53
Q

Schizophrenia
Course Cultural Differences:
More likely to be cared for by ______

A

family

54
Q

Schizophrenia
Course Cultural Differences:
_______ likely to be married

A

More

55
Q

Schizophrenia
Course Cultural Differences:
Extended ___________ may allow for more _______ re: home and life

A

family involvement; more role differentiation

56
Q

Schizophrenia
Course Cultural Differences:
Developed nations may foster a _______ patient mentality

A

professional

57
Q

Schizophrenia
Etiology: Genetics
Genetic factors account for up to ____ to _____ of variance in Sz.

A

60-80%

58
Q

Schizophrenia
Etiology: Genetics
Adopted children had ______ rates of Sz if their bio moms had Sz
IF they grew up in adopted family that was rated as _______

A

higher; dysfunctional

59
Q

Schizophrenia
Etiology: Neurodevelopmental Hypothesis
Diathesis + Stress = Sz

Diathesis is…

A

underlying vulnerability

60
Q

Schizophrenia
Etiology: Neurodevelopmental Hypothesis: Diathesis + Stress
Genetic Diathesis

A
  • If genetic, likely involves multiple genes

- Likely to develop into psychosis generally (vs. Sz specifically)

61
Q

Schizophrenia
Etiology: Neurodevelopmental Hypothesis: Diathesis + Stress
Environmental Diathesis

A

Maternal complications (rubella, diabetes, smoking)

62
Q

Schizophrenia
Etiology: Neurodevelopmental Hypothesis: Stress + Diathesis
1. Excessive _____ pruning during adolescence
2. Myelination
3. _______ use during adolescence increase risk of Sz.
4. Psycho_____ stress

A
  1. synaptic
  2. problems
  3. Cannabis
  4. Psychosocial
63
Q
Schizophrenia Etiology:
Brain Structural Issues:
Associated but not uniquely so with....
1. Enlarged \_\_\_\_\_
2. Decreased \_\_\_\_\_\_
A
  1. ventricles

2. gray matter

64
Q

Schizophrenia Etiology:
Dopamine Hypothesis:
Meds/drugs that increase dopamine lead to increase in _________

A

positive Sxs

65
Q

Schizophrenia Etiology:
Dopamine Hypothesis:
Sz involves dysfunction in the DA system but….

A

not as simple as too much DA in the system

66
Q
Schizophrenia Etiology:
Dopamine Hypothesis:
Other NTs likely to have a role:
1. \_\_\_\_\_\_\_
2. \_\_\_\_\_\_\_
A
  1. Glutamate

2. GABA

67
Q

Antipsychotic Tx administration methods:
1.
2.
3.

A
  1. Pill
  2. Liquid
  3. Depot (long term shot)

Affect DA and other neurotransmitters

A few days to work for agitation and hallucination

Several weeks to work for delusions

68
Q

Antipsychotic Meds

Clozapine (Clozaril)

A

Most effective antipsychotic by far but serious side effects preclude widespread usage - regular blood drawing.

Can cause agranulocytosis - loss of WBC

69
Q

Antipsychotic Side Effects:

Cardiac

A

QT prolongation

70
Q

Antipsychotic Side Effects:

Alertness levels:

A

Sedation

71
Q

Antipsychotic Side Effects:

Metabolic

A

Weight gain
Changes in metabolism
Increase risk of diabetes
Increase risk of high cholesterol

72
Q

Antipsychotic Side Effects:

Motor (Extrapyramidal)

A

Rigidity
Muscle Spasms
Tremors, restlessness

73
Q

Antipsychotic Side Effects:

Tardive Dyskinesia

A
  • Sudden involuntary muscle movements, typically around the mouth, tongue, and face.
  • Only sometimes reversible with meds discontinued.
74
Q

Antipsychotic Side Effects:
Weight gain
Which meds are worst?

A

Worst:
Zotepine (Zoleptil)
Olanzapine (Zyprexa)

75
Q

Antipsychotic Side Effects:
QTc Prolongation:
Which drugs are worst?

A

Worst:
Sertindole (Serdolect)
Amisulpride (Solian)

76
Q

Antipsychotic Side Effects:
Sedation:
Which meds are worst?

A

Worst:
Zuclopethixol (Clopixol)
Clozapine (Clozaril)

77
Q

Sz Tx:
Assertive Community Treatment: Med adherence is low for Sz, so ACT intervention developed.

Key Elements:

A
  • Multidisciplinary team
  • High patient contact
  • Reduced caseload
  • 24/7 availability
78
Q

Sz Tx:
Assertive Community Treatment: Med adherence is low for Sz, so ACT intervention developed.

Efficacy

A

Compared to Tx as Usual (TAU) ACT has

  • Increased med adherence
  • Increased quality of life
  • increased likelihood to be employed and living independently
  • decreased time in hospital/re-hospitalization
  • More cost effective
79
Q

Sz Tx:
Family Psycho-education/Decrease expressed emotion

Key elements:
Typically lasts 6-9 months and involves…

A
  • psychoeducation
  • communication skills
  • problem solving
  • decreased high expressed emotion
    • decreased hostility/criticism
    • decreased emotional over-involvement
80
Q

Sz Tx:
Family Psycho-education/Decrease expressed emotion

Efficacy:
Participants found to have…

A
  • higher functioning
  • higher med compliance
  • decreased hospitalization
  • decreased sense of burden among family members
81
Q

Cochrane Review of Interventions with Sz:

CBT

A

showed some efficacy for positive Sxs but not for negative

However

  • effects only lasted as long as continued CBT
  • higher the quality of the study (methodologically), the lower the effect size
82
Q

Cochrane Review of Interventions with Sz:

Social Skills training

A
  • some decrease in negative Sxs and relapse

- unclear if reaches significance level

83
Q

Cochrane Review of Interventions with Sz:

Supported employment

A
  • Individualized employment - some positive results re: retaining employment
  • low-quality data