Neurocognitive Dxs Mild and Major Flashcards

1
Q

Mild Neurocognitive Dx Diagnosis:

A. Evidence of modest cognitive decline from a previous level of performance in more than 1 cognitive domain based on:

A
  1. Concerns of the patient, a knowledgeable informant, or the clinician that there has been a mild decline
    AND
  2. A modest impairment in cognitive performance, preferably documented by standardized neuropsychological testing OR, in its absence, another quantified clinical assessment
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2
Q

Mild Neurocognitive Dx Diagnosis:

Mild Neurocognitive Dx means…

A

Mild = performance between 1 and 2 standard deviations below mean on testing.

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3
Q

Mild Neurocognitive Dx Diagnosis:
B. The cognitive deficits _______ interfere with capacity for independence in everyday activities

i.e. complex instrumental activities of daily living are _____ but greater effort, compensatory strategies, or accommodations may be required.

A

do not interfere; are preserved

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4
Q

Mild Neurocognitive Dx Diagnosis:

C. Cognitive deficits do not occur exclusively in the context of a ______

A

Delirium

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5
Q

Mild Neurocognitive Dx Diagnosis:

D. Not better explained by another _______

A

mental disorder (major depressive dx, schizophrenia

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6
Q

Mild Neurocognitive Dx Diagnosis:

Exception to a general rule…Normally the DSM-5 requires _____ (felt by the person) or ________ to be a Dx

A

distress; functional impairment

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7
Q

Qualitative review of impact of Mild Neurocognitive Dx

  1. Loss of control
  2. Living with ambiguity
  3. Anxiety re future
  4. Changing view of identity
A
  1. Partners no long include them equally in decisions
  2. Will this lead to Alzheimers? Are normal signs of aging really signs of dementia?
  3. Imagining individuals with dementia causes anxiety
  4. Nothing further noted
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8
Q

Major Neurocognitive Dx Diagnosis:
A. Evidence of significant cognitive decline from a previous level of performance in more than 1 cognitive domain based on:

A
  1. Concerns of the patient, a knowledgeable informant, or the clinician that there has been a significant decline
    AND
  2. A substantial impairment in cognitive performance, preferably documented by standardized neuropsychological testing OR, in its absence, another quantified clinical assessment
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9
Q

Major Neurocognitive Dx Diagnosis:

Major Neurocognitive Dx means…

A

Major = performance is greater than or equal to 2 standard deviations below the mean

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10
Q

Major Neurocognitive Dx Diagnosis:
B. The cognitive deficits ______ interfere with independence in everyday activities

i.e. at a minimum, requiring assistance with complex instrumental activities of daily living such as paying bills and managing medications

A

significantly

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11
Q

Major Neurocognitive Dx Diagnosis:

C. Cognitive deficits do not occur exclusively in the context of a ______

A

Delirium

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12
Q

Major Neurocognitive Dx Diagnosis:

D. Not better explained by another _______

A

mental dx (eg. major depressive Dx, schizophrenia)

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13
Q

Major Cognitive Dx Specifiers:

Types =

A
Alzheimers
Lewy Body
Frontotemporal
Vascular
Parkinsons
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14
Q

Major Cognitive Dx Specifiers:

Behavioral Disturbance Specifiers =

A

Psychotic Sxs
Mood
Agitation
Apathy

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15
Q

Major Cognitive Dx Specifiers:

Probably or Possible =

A

Relates to the certainty re: the causal agent

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16
Q

Exceptions to the general coding rules:

DSM-5 normally lists the medical cause before the psychiatric Dx, except for:

A
  1. Mild Neurocognitive Dx
  2. Unspecified Neurocognitive Dx
  3. Major Neurocognitive Dx - Possible Cause
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17
Q

Frontotemporal:

Onset

A

Insiduous - gradual. Remember Bolero. Different from Alzheimers in that occurs earlier in lifespan …45-65

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18
Q

Frontotemporal:

Cause

A

Deterioration in frontal and temporal lobes. Strong family hx

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19
Q

Frontotemporal
Sx Profile:
Behavioral Subtype

A

2/3 of patients experience a behavioral subtype (disinhibited, loss of empathy/sympathy, apathy, compulsive repetitive behaviors, hyperorality/pica)

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20
Q

Frontotemporal
Sx Profile:
Other 2 subtypes

A
  1. Semantic
  2. Progressive non-fluent

Language deficits (grammar errors, halting speech, word finding, word comprehension problems, etc.)

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21
Q

Vascular NCD:

Onset

A

Abrupt. Linked to cerebrovascular event (stroke or stroke-like event)

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22
Q

Vascular NCD:

Cause

A

Microscopic bleeding and blood vessel blockage

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23
Q

Vascular NCD:

Sx Profile

A
Depends on where event took place...
Typically problems seen in...
-Complex attention
-Processing speed
-Executive functioning
-Impaired judgment
-Often motor problems (shuffling gait, etc.)
24
Q

Vascular NCD:

Prevalence

A

2nd most common cause for NCD after Alz.

25
Q

Vascular NCD:

Course

A

Freq. stepped deterioration course (moves in stepwise fashion - different from the normal decline of dementia)

26
Q

Alcohol-Induced NCD:

Onset

A

Korsakoff’s

Often preceded by Wernicke’s encephalopathy

27
Q

Alcohol-Induced NCD:

Cause

A
  • Prominent white matter and neuronal loss

- Due to thiamine (vitamin B1) deficiency

28
Q

Alcohol-Induced NCD:

Sx profile

A
  • Impaired executive functions
  • difficulty with learning
  • apathy
  • memory impairment leads to confabulation
29
Q

Alcohol-Induced NCD:

Course

A

Wernicke’s encephalopathy - can be reversed if Tx administered early
-Tx = intravenous thiamine

30
Q

Parkinson (Lewy body):

Onset

A
  • Insidious
  • If motor Sxs present more than 1 year before NCD then NCD due to Parkinson
  • If motor Sxs NOT present for more than 1 year before NCD then NCD with Lewy bodies
31
Q

Parkinson (Lewy body):

Cause

A

-Deposits of the protein alpha-synuclein (called Lewy bodies) then this disrupts neurotransmitters (esp. dopamine and acetylcholine)

32
Q

Parkinson (Lewy body):

Sx profile

A
  • REM sleep behavior Dx
  • Vivid visual hallucinations
  • Delusions
  • Executive functioning problems
  • Drowsiness
  • Muscle rigidity/tremors
33
Q

Parkinson (Lewy body):

Course

A

-Periods of stability with abrupt periods of deterioration

34
Q

Parkinson (Lewy body):

Misc

A

-Antipsychotics worsen motor Sxs
-Tx = Dopamine agonists
These dopamine agonists can cause illusions and daytime sleepiness

35
Q

Alzheimer’s:

Onset

A

-Slow, insidious

36
Q

Alzheimer’s:

Cause

A

-Plaques (amyloid beta deposits), neurofibrillary tangles (protein-tau) accumulate in cell bodies

37
Q

Alzheimer’s:

Sx profile

A

-Decline memory/learning + more than 1 other cognitive domain

38
Q

Alzheimer’s:

Course

A
  • Steady progression

- Death approximately 8-10 years after Sxs

39
Q

Alzheimer’s:

Misc

A

Sundowning - Sxs worsen after sunset

40
Q

Alzheimer’s Dementia -Basic info:

Brain changes may begin more than _____ before Sxs

A

more than 20 years

41
Q

Alzheimer’s Dementia -Basic info:

30% of those with ______ show signs of Alzheimer’s in their 50s

A

Down Syndrome

42
Q

NCD Tx:

Acetylcholine Breakdown Inhibitors

A

Donepezil - ARICEPT
Rivastigmine- EXELON Galantamine - RAZADYNE

  • All are equal in efficacy but effect size of any is not large.
  • Effect is slightly better for Parkin’s/Lewy body than for Alzheimer’s or Vascular
43
Q

Antipsychotics and Exercise:

Use of antipsychotics in elderly patients with dementia _____ risk of death

A

Increases

44
Q

Antipsychotics and Exercise:

FDA issued a _______ against their use in dementia

A

Black box warning

45
Q

Antipsychotics and Exercise:

Reduction in antipsychotic use has been ______

A

limited

46
Q

Antipsychotics and Exercise:

Exercise has _______ impact on health and ____ effect on cognition

A

positive; some

47
Q

Cognitive Stimulation Therapy:

Stimulation of one’s _____, _____, and _______

A

thinking; concentration; memory

48
Q

Cognitive Stimulation Therapy:

Usually in a ______ group, social setting

A

small

49
Q

Cognitive Stimulation Therapy:

May include elements of _______ therapy

A

reminiscence therapy

(discussion of past experiences - with physical prompts - such as phots

50
Q

Cognitive Stimulation Therapy:

Results

A

Positive effect on language and cognition

Small effect size when compared with active controls

51
Q

Tx of Dementias - Psychosocial:

Be aware of ______ in Sxs

A

variations

sundowning in Alz.

52
Q

Tx of Dementias - Psychosocial:

Supportive and _______

A

affectionate

53
Q

Tx of Dementias - Psychosocial:

Gentle ______

A

reminders: orientation; signs and notes

54
Q

Tx of Dementias - Psychosocial:

Maintain familiar _______

A

schedules

55
Q

Tx of Dementias - Psychosocial:

Ask ______ to tap ______ vs. recall memory

A

questions; recognition

Was that x or y at the door? vs. Who was at the door?

56
Q

Tx of Dementias - Psychosocial:

Most care for dementia is delivered by _____

A

family members