schiz

Question 1

1 RF for non complance

Answer 1

lack of insight

Question 2

RF for schiz

Answer 2

winter birth 10% increasein risk
birth complications RR=2
paternal age over 35
males have higher incidence though prevalence is the same. RR: 1.4
urban birth
urban drift theory also corroborated
dose response risk with duration spent in urban place
migration: 1st generation RR 2.7, 2nd generation is 4.5
for RF if you must guess RR, guess 2-3 except for genetic RR its higher

Question 3

non adherence and LAI

Answer 3

nonadherence is between 45 and 90%

LAI do not change this Canadian J 2013

Question 4

cognitive deficits

Answer 4

80% of schiz have it
1 SD below the mean
mainly processing speed, but all domains
Clozapine is the only drug that may help

Question 5

schizophrenia risk of premature death RR

Answer 5

2

Question 6

ultra high risk criteria in detail

Answer 6

15-25 yrs
referred to specialized service
falls under one of the following 3 groups:
1: attenuated +ve sx: several times a week, 1 wk-5 yrs duration, present within the last yr

2: BLIPS: same sx as above seems like, several times a week, less than a week, present in the past year
3: Schizotypal PD or FH of psychosis (1st degree) plus decline in functioning for 1-5 yrs, present in the past yr

Question 7

1 yr relapse rate with:
meds only
add social skills to meds 
add family Tx to meds
everything together

Answer 7

40%
20%
15%
0%

Question 8

most specific and prognostic prodromal sx

Answer 8

attentuated positive sx

Question 9

RR of urbanicity
RR of cannabis
1st degree relative

Answer 9

2-4
2-25
10

Question 10

age of onset

Answer 10

15-25

women have another peak 55-65

Question 11

outcome in schizpredicted most by?

Answer 11

amount of time psychotic in 1st two yrs of illness

Question 12

genes in schiz

Answer 12

COMTpolymorphism, methionin instead of valine, reduces activity of enzyme, too much DA