dementia Flashcards
1
Q
scale for funcitons
A
functional assessment scale
10 items
0-3
IADLs mostly
2
Q
MCI numbers
A
prevalence: 10-20% of those over 65 convert 5-10% per yr in community 10-15% in clinical samples 25% revert back to N 90% of the amnestic type progress to Alz
3
Q
pie chart of dementia types
A
Alz 65%
vascular 20%
other 15%
4
Q
genes in Alz
A
mostly sporadic but of those who have alz, 50% have family hx APO e4 on ch 19 Presenelin 1 on Ch 14 Presenelin 2 on Ch 1 APP on ch 21
5
Q
genes in FTD
A
mostly sporadic
10@ dt genes
TAY and TDP 34 on Ch 17
6
Q
Huntingtons genes
A
CAG repeats ( > 36)
AD
Ch 4
7
Q
genes in LBD
A
sporadic
Some familial aggregation
candidate gene is GBA on ch 1
8
Q
ALz pathology
A
beta 42 amyloid gives plaques
Hyperphosphorylation of TAU gives u tangles
9
Q
FTD pathology
A
TAU
TDP 34
Ubuquitin
10
Q
LBD and PDD pathology
A
alpha synuclein
11
Q
scale for BPSD
meds?
A
neuropsychiatric inventory SSRIs Trazodone RisperdalAbilify ACEI may precent or delay but would not initiate for Tx in Alz
