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SBL > SBL 2 > Flashcards

SBL 2 Flashcards

1
Q

Mentzer index

A 
>13 = iron deficieny
<13 = beta thalassemia
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2
Q

How to calculate mentzer

A

=MCV/RBC

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3
Q

kasabach meritt syndrome

A

thrombocytopenia and hypofibrinogenemia secondary to giant hemangioma and associated intravascular coagulation

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4
Q

most common cancer among children?

A

leukemia

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5
Q

most common cancer in adolescent?

A

lymphoma

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6
Q

Most common cancer in younger children?

A

leukemia

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7
Q

Hodgkin lymphoma is most common cancer in what age?

A

15-19

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8
Q

Best test to diagnose HL

A

should undergo chest radiography to rule out a mediastinal mass

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9
Q

Is HL or NHL more common in adolescents?

A

HL

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10
Q

What does NHL survival depend on?

A
  • pathologic type
  • tumor burden at diagnosis as reflected in LDH
  • presence or absence of CNS disease
  • sites of mets
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11
Q

How do you calculate absolute neutrophil count?

A

((%neutrophils+%bands) *WBC) / 100

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12
Q

What is moderate neutropenia in terms ANC?

A

500-100

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13
Q

Describe severe congenital neutropenia (kostmann syndrome)

A

life threatening pyogenic infection in infancy due to impaired myeloid differentiation caused by maturational arrest of neutrophil precursors.

  • AR
  • increased risk of AML
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14
Q

Describe cyclic neutropenia

A
  • cyclic fevers, oral ulcers, gingivitis, periodontal disease, recurrent bacterial infections due to a defect in stem cell reg defect
  • sporadic or AD
  • No increased risk of malignancy
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15
Q

Describe shwachman-diamond syndrome

A
  • triad of neutropenia, exocrine pancreas insuficcienct, and skeletal abnormalities
  • AR
  • Increased risk for myelodysplastic syndrome or leukemia
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16
Q

Most common tumor of infancy?

A

hemangioma

17
Q

If there is a cutaneous neuroblastoma what will you see? How about on labs?

A

Blueberry muffin. Increased VMA and HVA

18
Q

What is the most common primary renal tumor of childhood?

A

Wilms tumor

19
Q

Describe Beckwith Weidmann

A

Wilms tumors
Macroglossia
Muscle hemihypertrophy
Organomegaly

20
Q

What shifts o2 curve to the right?

A

Increased 2,3 DPG, decreased pH, increased temp, increased o2.

21
Q

What shifts an o2 curve to the left?

A

Increased HbF, increased CO. Also, opposite of what curves it to the right.

22
Q

What is the physiologic nidar in children?

A

At 2 months old, normal decrease in hemoglobin and hematocrit. Can be scary once you see infections

23
Q

What is the cause of congenital pure red cell aplasia?

A

diamond blackfan syndrome

24
Q

Describe diamond Blackman syndrome

A

macrocytic anemia with low reticulocyte count

25
Q

What is the most common inherited form of aplastic anemia?

A

fanconi anemia

26
Q

What is TAR syndrome?

A

thrombocytopenia with absent radius`

27
Q

Many viruses cause what within the first 2-3 days of illness?

A

Neutropenia. Can last up to 1 week

28
Q

What is a notorious cause of neutropenia?

A

Chemotherapy drugs

29
Q

What nutritional deficiency can cause neutropenia?

A

b12

30
Q

What 4 things can cause a leukocytosis?

A

infection, autoimmune, oncologic, seziure

SBL (2 decks)

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