SB L3 Reading

Question 1

ECT increases ……………. in the hippocampus - this responce is attenuated in mice with ……………

ref?

Answer 1

dendritic sprouting

attunuated in mice with reduced BDNF

(Vaidya 1999)

Question 2

Although BDNF is clearly involved in antidepressant response what 2 evidences are there against this?

ref?

Answer 2

reduction of BDNF levels or BDNF signalling does not cause depresssion like symptoms

(Castren 2007)

Over expression of trkB receptor fails to produvce depression-like effects in the forced swim test (Saarelainen 2003)