Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

CNS - Sarah Bailey > SB L3 - Neurogenesis part 2 > Flashcards

SB L3 - Neurogenesis part 2 Flashcards

1
Q

PTSD brain anatomy shows?

A

decreased hippocampal volume

  • is this because we are not making new cells or due to cell death/atrophy/less branching?
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the effect of antidepressants and ECT on neurogenesis?

A

stimulates it

both proliferation and survival

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Another labeling technique similar to BrdU?

A

3H[thyamine]

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Prolonged stress brain anatomy shows?

A

decreased hippocampal neurogenesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Proposed mechanism of why there is less hippocampal neurogenesis in MDD?

A

cortisol is elevated in MDD - negatively regulates neurogenesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Antidepressants and neurogenesis actuely vs chronically?

A

If you look at the Fluoxetine data not much happens after a day but chronically you get a significant increase in cells.

Is this why 4-6 weeks to effect?

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

SSRIs require….. receptor for neurogensis

A

5ht1a

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Describe novelty supressed feeding task

A

paradigm where you have five days where you train them to eat something yummy for three days, they learn that it’s nice. On the fours day you do a test to see how long it takes them to approach the thing theyve learnt is yummy. Then you put them in a sparse bright cage (aversive environment). So there is a conflict between the two so the approach is always longer, so you look at latency.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What does novelty supressed feeding show with antidepressants?

with antidepressants in 5HT1A KO?

A

All antidepressants reduce the time to feed.

In KO 5HT1A animals are anxious and there is latency to feed. Imipramine (TCA so not selective to serotonin) and some others are not affected.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

5HT1A KO and fluorextine showed…. (2)?

Ref

A
  1. KO mice are selectively insensitive to the behavioural effects of fluoxetine in a novelty- suppressed feeding task
  2. KO mice are selectively insensitive to the neurogenic effects of fluoxetine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Effect of ECS (what even is this) on mRNAs in the hippocampus?

A

upregulates BDNF, Trk B and VEGF mRNAs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Effects of SSRIs, TCAs, MAOIs, on mRNA in the hippocampus?

A

increasews BDNF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How does antidepressant treamtents affect autophosphyrylation of TrkB?

A

increased - constitutatively activates the pathway bypassing BDNF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Overall effect of stress on:

a. gulcoricoids
b. VEGF
c. neurogenesis

A

increased GC
decresed VEGF =

decreased neurogenesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

over all effect of antidepressant therapy on

a. neurotransmitters (2)
b. VEGF
c. BDNF
d. neurogenesis

A

increased NE and 5HT

increased VEGF
increased BDNF
increased neurogenesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

over all effect of antidepressant therapy on

a. neurotransmitters (2)
b. VEGF
c. BDNF
d. neurogenesis

A

increased NE and 5HT

increased VEGF
increased BDNF
increased neurogenesis

17
Q

BDNF levels are ………………….. in postmortum depressed pt

A

decreased

18
Q

How do antidepressants effect BDNF levels?

A

restore them (increase)

19
Q

A SNP in BDNF is associated with ……. and ……

A

memory impairments and mood disorders

  • The substitution is present in the pro gene that needs to be cleaved to make the BDNF.
  • Carriers of the mutation have a smaller hippocamul volume.
20
Q

BDNF Val66Met mice show

ref

A

Increased anxiety-related behaviour that is resistant to treatment with fluoxetine (in terms of percentage of time in closed areas)

Chen et al. Science 2006

21
Q

BDNF Val66Met mice show

ref

A

Increased anxiety-related behaviour that is resistant to treatment with fluoxetine (in terms of percentage of time in closed areas)

Chen et al. Science 2006

22
Q

Why might making a small molecule netrophic factor drug be a poor therapeutic target? (3)

A

id you inject it into the brain it just stats where it is. Could use s/c.

Stumulates growth of many things - cancer?

Must ensure it can cross the BBB

23
Q

There is debate about whether nerogenesis is ……. or …… of depression

A

cause or consequence

-maybe you get impaired neurogen from genes/envirmonent making you vulnerable to disorders. Does this matter when treating as all antidepressants affect it?

24
Q

Antidepressant effects can be abolised by

ref

A

x-ray hippocampal irradiation - in some behavioural paradigms but not in others

25
Q

Problems with neurogen theory?

A
  1. Neurogenesis effects of antidepressands vary with species and genetics
  2. Decreasing neurogenesis in animal models doesn’t cause depression
  3. Depressed patients do not have reduced neuronal cell proliferation
  4. Hippocamp neurgen implicated in many disorders
26
Q

Problems with neurogen theory?

A
  1. Neurogenesis effects of antidepressands vary with species and genetics
  2. Decreasing neurogenesis in animal models doesn’t cause depression
  3. Depressed patients do not have reduced neuronal cell proliferation
  4. Hippocamp neurgen implicated in many disorders

CNS - Sarah Bailey (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions