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SAS 7 Flashcards

1
Q

A reaction between two or more drugs or between a drug and a food beverage or supplement

A

Drug interaction

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2
Q

It is the modification of the therapeutic effect of one drug by the prior concominant administration of another

A

Therapeutic incompatibility

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3
Q

Any noxious or unintended reaction to a drug that is administered in standard doses by the proper route for the purpose of prophylaxis, diagnosis or treatment

A

ADR Adverse Drug Reactions

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4
Q

An action of a drug on the effectiveness or toxicity of another drug

A

Drug interaction - a.k.a drug-adjuvant interaction

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5
Q

Precipitant drug

A

Responsible

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6
Q

Object drug

A

Affected

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7
Q

Occurs when one drug enhances or interferes with the absorption, distribution, metabolism or excretion of another drug resulting in a change in drug concentration in the body or the duration of the drug’s availability at the receptor sites

A

Pharmacokinetic interactions (ADME)

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8
Q

When a precipitant drug affects the absorption of an object drug, the concentration of the drug in the plasma is either increased or decreased

A

Alteration in absorption

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9
Q

Absorption of some drugs from GIT is dependent on the pH of the fluid in absorption site

A

Alreration in the Gastric pH

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10
Q

Ketoconazole+Antacid

A

Alteration in Gastric pH

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11
Q

Bisacodyl+Antacid

A

Alteration in Gastric pH

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12
Q

Some drugs may form irreversible chelates in the presence of another drug rendering both drugs inactive

A

Complexation

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13
Q

Tetracycline + Metals

A

Complexation

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14
Q

Fluoroquinolones + Metals

A

Complexation

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15
Q

Penicillamine + Metal-containing drugs

A

Complexation

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16
Q

Non-specific binding of a drug to another agent

A

Adsorption

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17
Q

Cholestyramime + warfarin = thrombosis

A

Adsorption

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18
Q

the time it takes for the stomach to empty it’s content

A

Gastric Empting Time

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19
Q

Cathartics + Antacid

A

Alteration in GET

20
Q

Atropine + Antacid

A

Alteration in GET

21
Q

OCP + Antibiotic = unwanted pregnancy

A

Alteration in GI Flora

22
Q

displacement from plasma protein binding site

A

Alteration in Distribution

23
Q

Phenylbutazone + Warfarin = hemorrhage

A

Alreration in Distribution

24
Q

Sulfonamides + OHA = hypoglycemia

A

Alteration in Distribution

25
Q

Process by which drugs are converted into more.polar and hydrophilic molecules to make it easier to eliminate through the kidneys

A

Metabolism

26
Q

Process by which a drug or molecule enhances the action kf an enzyme towards another drug resulting in a faster inactivation of drug

A

Enzyme induction

27
Q

Phenobarbital + Warfarin = thrombosis

A

Enzyme induction

28
Q

process by which a drug or molecule inhibits the action of an enzyme towards another drug resulting in a slower rate of metabolism

A

Enzyme inhibition

29
Q

NaHCO3 + ASA

A

Alteration in urinary pH

30
Q

Penicillin + Probenecid

A

Alteration in Active transport

31
Q

Occur when one drug alters the effect of another drug at its site of action without altering the systematic concentration of a drug

A

Pharmacodynamic interaction

32
Q

Concurrent administration of two drugs acting on the same mechanism, the final effect of which is the same as the algebraic sum of their separate effects

33
Q

BZD + Antihistamine = sedation

34
Q

Beta blockers + Non-DHPs

35
Q

Results when two drugs on similar mechanism enhance the action of each other to produce an effect much greater than the sum of each drug acting separately

36
Q

Occurs when two drugs acting on different mechanism or receptors are raken together and one of them intensifies the action of the other

A

Potentiation

37
Q

Amoxicillin + Clavulanic acid

A

Potentiation

38
Q

Ampicillin + Sulbactam

A

Potentiation

39
Q

Piperacillin + Tazobactam

A

Potentiation

40
Q

Legodopa + Carbidopa

A

Potentiation

41
Q

Two drugs with opposing action may result in the reduction or cancellation of the effect of one or drug drugs

A

Antagonism

42
Q

Naloxone + Morphine

A

Antagonism

43
Q

Warfarin + Green Leafy Vegetables

A

Drug-Food interaction

44
Q

Spironolactone + Banana

A

Drug-food interaction

45
Q

Rifampicin + Urinalysis

A

Drug-Laboratory Interactions

Dispensing 2 (5 decks)

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