SAS 6

Question 1

Are physical and chemical reactions that occur in vitro between two or more drug when the solutions are combined in the same syringe, tubing, or bottle

Answer 1

Incompatibilities

Question 2

This type of reaction can cause visible changes, including precipitation; changes in color, consistency, or oplescence; or gas production

Answer 2

Physical reactions

Question 3

occurs more commonly with multiple additives.

Answer 3

Physical incompatibility

Question 4

occurs when mixing two drugs and changes the potency of their active ingredients

Answer 4

Chemical incompatibility

Question 5

Is a term used to describe the interaction of two of more substances that result in changes to the medical, physical, or chemical properties of the pharmaceutical dosage forms

Answer 5

Compatibility

Question 6

ICU means..

Answer 6

Intensive care unit

Question 7

is an undesirable reaction that occurs between the drug and the solution, container or another drug

Answer 7

Incompatibility

Question 8

Means outside the living body and in an artificial environment such as test tube or petri dish

Answer 8

In-vitro

Question 9

Means within a living organism such as plant or animal

Answer 9

In-vivo

Question 10

A type of manifestion that happens between solids and liquids

Answer 10

Incomplete Solution: Insolubility

Question 11

A type of manifestion that has the inability of the solid material to dissolve in a particular solvent system

Answer 11

Incomplete Solution: Insolubility

Question 12

A type of manifestion that two or more liquids fail to mix homogenously

Answer 12

Incomplete Solution: Immiscibility

Question 13

A type of manifestion that occurs due to solvent is insoluble when it is added to solution

Answer 13

Precipitation

Question 14

A type of manifestion that results when highly hydrted inorganic ions deprive organic ions and molecules of adequate water molecules to remain dissolved

Answer 14

Precipitation: Salting-out a.k.a DEHYDRATION

Question 15

A type of manifestion that electrolytes and Non-electrolytes compete for water molecules

Answer 15

Precipitation: Salting-out a.k.a DEHYDRATION

Question 16

A type of manifestion that absorbs heat=increase temp of solution=increase solubility

Answer 16

Precipitation: Change in temperature: Endothermic reaction

Question 17

A type of manifestion that gives off heat=decrease temp=decrease solubility of the solution

Answer 17

Precipitation: Change in temperature: Exothermic Reaction

Question 18

A type of manifestion that absorbs moisture=liquefy

Answer 18

Liquefaction/Melting: Deliquescence

Question 19

A type of manifestion that is due to lowering of MP of two olids combined together at room temperature

Answer 19

Liquefaction/Melting: Eutexia

Question 20

A type of manifestion that releases H2O of crystallization

Answer 20

Liquefaction/Melting: Efflorescence

Question 21

A type of manifestion that increases vapor pressure

Answer 21

Vaporization

Question 22

A type of manifestion that has the ability of a substance to exist in different crystalline forms

Answer 22

Polymorphism

Question 23

A type of manifestion that is a reverse of liquefaction

Answer 23

Water loss

Question 24

Type of incompatibility: Gum+alcohol

Answer 24

Insolubility

Question 25

Type of incompatibility: **Oil+water**

Answer 25

Immiscibility

Question 26

Type of incompatibility: **Camphor+water+KBr**

Answer 26

Salting-out

Question 27

Type of incompatibility: **Ammonium chloride solution**

Answer 27

Endothermic reaction

Question 28

Type of incompatibility: **Crumbling of ointments**

Answer 28

Water loss

Question 29

Type of occurence: **Dehydrogenation**

Answer 29

Oxidation

Question 30

Type of occurence: **VILEORA**

Answer 30

Oxidation

Question 31

Type of occurence: **Hydrogenation**

Answer 31

Reduction

Question 32

Type of occurence: **VDGEROA**

Answer 32

Reduction

Question 33

Type of occurence: **Ca(OH)2 + CO2**

Answer 33

Acid base reaction: *Precipitation*

Question 34

Type of occurence: **Effervescent granules**

Answer 34

Acid-base reaction: *Evolution of gas*

Question 35

Type of occurence: **most common cause of degradation; eg. Ester, ASA, Amide**

Answer 35

Hydrolysis

Question 36

Type of occurence: **a.k.a Photooxidation, Photolysis**

Answer 36

Photochemical Degradation

Question 37

Type of occurence: **occurence of an optically active drug to an optically inactive drug**

Answer 37

Racemization

Question 38

Type of occurence: **Racemic mixture**

Answer 38

Racemization

Question 39

Type of occurence: **Formation of gels**

Answer 39

Gelatinization

Question 40

Type of occurence: **formation of cake**

Answer 40

cementation

Question 41

Chemical can be changing the order of mixing the solutions in dilute forms, without or by changing the order of mixing

Answer 41

Tolerated incompatibility

Question 42

change in the formulation is needed with a compound having equal therapeutic value

Answer 42

Adjusted incompatibilities

Question 43

chemical reaction takes place, immediately after combining the prescription ingredients

Answer 43

Immediate incompatibility

Question 44

chemical reaction proceeds at a very slow rate and no appreciable visible change occurs which may develop on keeping the product for a long time

Answer 44

Delayed incompatibility

Question 45

When the prescriber knowingly prescribes the imcompatible drugs

Answer 45

Intentional

Question 46

When the prescriber prescribes the drugs without knowing that there is incompatibility between the prescribed drugs

Answer 46

Unidirectional