SAS 2 | Inflammation & Inflammatory Response

Question 1

Acute inflammation

Answer 1

Comes on rapidly , but is generally short-lived.

Question 2

Chronic Inflammation

Answer 2

Often begins with the same cellular response, but morphs into a lingering state that persists for months or years when the immune system response fails to eliminate the problem.

Question 3

What are the major events of an Inflammatory response

Answer 3

1. Vasodilation
2. Increase in capillary permeability
3. Influx of Phagocytes

Question 4

What is an Alarmins?

Answer 4

DAMPS
-Molecules that are released by dead cells, also secreted by sentinel cells
Function: Recruit and activate cells of the innate immune system and indirectly promote acquired immune reponse

Question 5

PAMPS?

Answer 5

Pathogen-Associated Molecular Pattern
(Refer to book)

Question 6

Cell wall of gram-positive

Answer 6

Peptidoglycans and lipoteichoic acid

Question 7

Cell wall of gram-negative bacteria

Answer 7

Peptidoglycan that is covered with a layer of Lipopolysaccharaides (LPS)

Question 8

Acid-fast bacteria cell wall

Answer 8

Glycolipids

Question 9

Yeast cell wall

Answer 9

Mannan-rich carbohydrate wall.

Question 10

TLR on the cell surface
- What can they detect?

Answer 10

TLR3 - ds viral DNA,
TLT 4 - Lipopolysaccharide of Gram-negative bacteria
TLR 5 - flagellin

Question 11

TLR within the cells

Answer 11

TLR 3
TLR 7
TLR9