Sarcoidosis Flashcards
1
Q
define sarcoidosis
A
multisystem granulomatous disorder
2
Q
what age group does sarcoidosis usually affect?
A
young adults
3
Q
how does sarcoidosis present
A
- bilateral hilar lymphadenopathy
- pulmonary infiltration
- skin lesions (erythema nodosum)
- eye lesions (anterior uveitis, conjunctivitis)
- fatigue
- weight loss
- hypercalcaemia
4
Q
how is sarcoidosis detected?
A
CXR
5
Q
what group of people is sarcoidosis more virulent in?
A
black people
6
Q
inflammatory cells involved in sarcoid granulomas
A
- epithelioid cells
- macrophages
- T lymphocytes
7
Q
other causes of bilateral hilar lymphadenopathy
A
- lymphoma
- pulmonary TB
- bronchial carcinoma
8
Q
pathology of sarcoidosis
A
honeycomb appearance
9
Q
investigations into sarcoidosis
A
- CXR
- high resolution CT(good assessment for diffuse parenchymal lung disease)
- transbronchial biopsy
- lung function tests
10
Q
what does the lung function tests show for sarcoidosis
A
restrictive defect
11
Q
do you treat if asymptomatic
A
no
12
Q
management if symptomatic
A
- corticosteroids (prednisolone)
- cytotoxic drugs e.g. methotrexate and azathioprine
