Sarcoidosis

Question 1

Age of sarcoidosis

Answer 1

20 - 40

Question 2

Sarcoid genetics

Answer 2

ass with HLA DRB1 and DQB1

Question 3

Sarcoid cause

Answer 3

unknown

a multi-system granulomatous disorder

Question 4

Acute sarcoid presentation

Answer 4

erythema nodosum

+/- polyarthalgia

(usually resolves spontaneously)

Question 5

Sarcoid pulmonary sx

Answer 5

Dry cough,

progressive SOB

chest pain

progressive deterioration in lung function (10-20%)

Question 6

CXR findings of sarcoid

Answer 6

bilateral hilar lymphadenopathy (BHL) ± pulmonary infiltrates or fibrosis

Question 7

Staging of sarcoid

Answer 7

Stage 0: normal

Stage 1: BHL

Stage 2: BHL + peripheral pulmonary infiltrates

Stage 3: peripheral pulmonary infiltrates alone

Stage 4: progressive pulmonary fibrosis; bulla formation (honeycombing); pleural involvement.

Question 8

Eye sx of sarcoid

Answer 8

uveitis

conjunctivitis

keratoconjunctivitis sicca

glaucoma

Question 9

Neurological sx of sarcoid

Answer 9

Bell’s palsy

Neuropathy

Meningitis

Space-occupying lesion

Question 10

Dermatological sx of sarcoid

Answer 10

lupus pernio

erythema nodosum

Question 11

Cardiac sx of sarcoid

Answer 11

cardiomyopathy

arrythmias

Question 12

Renal sx of sarcoid

Answer 12

renal stones (hypercalciuria)

Question 13

Diagnostic test for sarcoid

Answer 13

non-caseating granulomata on tissue biopsy

Question 14

Sarcoid bone changes

Answer 14

terminal phalangeal bone cysts

punched out lesions in terminal phalanges on xray

Question 15

Rx of stage 1 sarcoid

Answer 15

don’t need treatment as most recover spontaneously

Question 16

Acute sarcoid rx

Answer 16

NSAIDS

bed rest

Question 17

Meds rx of sarcoid

Answer 17

Prednisilone

Severe disease; methylpred (IV) or immunosuppressants (eg methotrexate)

Question 18

Indications for steroids for sarcoid

Answer 18

Parenchymal lung disease (symptomatic, static, or progressive)

Uveitis

Hypercalcaemia

Neurological or cardiac involvement.