Sarcoidosis

Question 1

What is sarcoidosis

Answer 1

a multisystem disorder of unknown cause characterised by non-caseating granulomas. It is more common in young adults and african people

Question 2

Features of Sarcoidosis

Answer 2

Acutely – erythema nodosum, bilateral hilar lymphadenopathy, a ‘swinging’ fever and polyarthralgia.
Insidious – dyspnoea, non-productive cough, malaise & weight loss
Can have lupus pernio and hypercalcaemia

Question 3

Lofgren’s Syndromes

Answer 3

an acute form with bilateral hilar lymphadenopathy (BHL), erythema nodosum, fever and polyarthralgia. it usually has an excellent prognosis

Question 4

Heerfordt’s syndrome

Answer 4

Uveoparotid fever - parotid enlargement with fever and uveitis secondary to sarcoidosis

Question 5

Why does sarcoidosis give you hypercalcaemia?

Answer 5

Macrophages in the granulomas cause increased conversion of Vit D to its active form

Question 6

Lupus pernio

Answer 6

Chronic, raised and hardened purplish lesion of the skin on face, hands or fingers. resembles frost bite.

Question 7

Treat with steroids if

Answer 7

Hypercalcaemia, worsening lung function or heart, eye or neurological involvement.