Sarah Bailey HPA axis Flashcards
Mifepristone is a GR antagonist at high doses and was reported to relieve psychotic and depressive symptoms of cushings patients
Van der lely 1991
Mifepristone decreased immobility time in the forced swim test in mice studies
Wulsin et al 2010
Elevated cortisol is a consistent feature of major depressive disorder
Kathol et al 1989
Psychotic major depressive patients demonstrate significant elevation in HPA activity due to impaired negative feedback demonstrated in the dexamethasone test
Schatzberg 2015
Antidepressant treatments result in reduced CRF in the CSF of healthy and depressed patients
Hernando 2015
Psychotic major depressive patients demonstrate significant impairment in cognition, high cortisol levels correlate with a number of cognitive deficits
Schatzberg 2015
Depressed patients showed increased levels of CRF in the CSF and increased levels of CRF mRNA expression in the PVN compared to controls
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Psychological stress is an important trigger in the development of depression and MDD is associated with an altered ability to adapt to a stressful stimulus
Post 1992
Ketoconazole and metyrapone resulted in an improvement of depressive symptoms in the majority of patients
Murphy 1997
Metyrapone has been shown to augment the effects of imipramine in the forced swim test in rats
Rogoz et al 2005
Over production of CRF in transgenic mice increases anxiety related behaviour
Stenzel poore et al 1994
Increased CRF in depressed patients, direct injection of CRF increases anxiety, antisense strategies to knockdown CRF reduced anxiety
Banki et al 1992
R121919 is a CRFR1 antagonist that had good solubility and crossed BBB and improved anxiety and depression states in clinical trials but was stopped due to hepatotoxicty
Zobel et al 2000
Downregulation of CRF receptors in suicide victims
Merali et al 2004
