Sarah Bailey 5HT1A

Question 1

Time taken for 5HT firing to recover after desensitisation correlates with the time taken for anxiolytics such as buspirone to have a therapeutic effect

Answer 1

Blier and ward 2003

Question 2

Polymorphisms in the human 5HT1A receptor promoter regulating expression found a reduction in the expression of 5HT1A receptors in those with anxiety disorders

Answer 2

Lesch and gutknecht 2004

Question 3

Decreased 5HT1A levels supported in other studies such as

Answer 3

Neumeister 2004

Question 4

Mice with reduced 5HT1A receptor gene expression during the postnatal period demonstrate exaggerated anxiety responses which persist into adulthood

Answer 4

Gross et al 2002

Question 5

Dual 5HT1A/B receptor antagonist + SSRI (SB649915) demonstrates acute anxiolytics activity in both rodents and non-human primates and reduced latency to onset of anxiolytics behaviour

Answer 5

Watson and Dawson 2007