Sara

Question 1

What is the Fc Receptor on NK cells?

Answer 1

CD16 FcyRIII

Question 2

How are NKs activated? (1)

Answer 2

2B4 expressed on innate immune cells (e.g. NK cells) bound with CD48 (activating receptor expressed on APCs and T cells) to form a signal to activate cell

Question 3

How are NKs activated? (2)

Answer 3

NKG2D (receptor expressed on NK cells) binds to MICA or MICB (produced by stressed gene/target cell) to produce a signal and activate the cell

Question 4

How are NKs activated? (3)

Answer 4

Fc receptor (CD16 FcyRIII) (for example) bind IgG-antigen complexes and activate NK cells without another receptor

Question 5

All NK cells express?

Answer 5

CD56

Question 6

NKG2D is a…

Answer 6

Homodimer

Question 7

DAP10 is a…

Answer 7

Cell surface adapter protein in an activating receptor complex with NKG2D

Question 8

What is ULPB

Answer 8

A UL16 binding protein

Question 9

What is UL16?

Answer 9

HCMV (human cytomegalovirus) gene that encodes a glycoprotein UL16 which interferes with the immune response to virus infected cells (in vitro interacts with MICB and ULBPs - ligands for stimulatory receptor NKG2D, which is expressed on NK cells and CD8+ T cells)

Question 10

What is absent from NK cells?

Answer 10

CD3

Question 11

What is CD94:NKG2D?

Answer 11

An inhibitory receptor complex on NK cell surface. CD94 (type II transmembrane protein) forms a disulphide linked heterodimer with NKG2D (member of NKG2 receptor family). Part of C-type lectin like family which recognises the HLA-E ligand (with a limited subset of peptides derived from stressed MHC Class I molecules; HLA-A, B, and C), contacts the peptide and two alpha helices.