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Rodent Module > Sample Questions > Flashcards

Sample Questions Flashcards

1
Q

Which of the following methods of killing appears on schedule 1 of the ASPA and can be used by competent people to kill protected animals at designated establishments?
A. Dislocation of the next for all species up to 1kg
B. Overdose of appropriate anesthetic followed by exsanguination for all animals
C. Cooling followed by immersion in cold tissue fixative, for rodent fetuses
D. Decapitation for rabbits

A

B. Overdose of appropriate anesthetic followed by exsanguination for all animals

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2
Q

As a personal licensee, if you need to kill an animal by a method that isn’t listed under Schedule 1, what should you check before performing it?
A. You have permission from nACWO
B. You have authorization in the relevant project license
C. You have the permission of the relevant project license holder
D. You have authorization in the relevant project license and in your personal license

A

D. You have authorization in the relevant project license and in your personal license

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3
Q

Schedule 1 lists which of the following as appropriate for killing a 300g rat
A. Immersion in liquid nitrogen
B. Overdose of appropriate anesthetic by injection
C. Decapitation
D. Application of electric current across the brain

A

B. Overdose of appropriate anesthetic by injection

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4
Q

When using gaseous anesthetic agents in animals, which is the best method for avoiding toxic effects of the volatile vapors on personnel?
A. Disposable face mask for animal
B. Face mask for operator
C. Sufficient air changes in room
D. Exhaust waste gases through activated-charcoal

A

D. Exhaust waste gases through activated-charcoal

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5
Q

Which of the following is a potential zoonosis from a UK laboratory bred rat?
A. Chlamydia
B. Streptobacillus moniliformis
C. Rabies virus
D. Influenza virus

A

B. Streptobacillus moniliformis

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6
Q

One indication that a rodent is suffering from ill health or pain may be that it:
A. is active and alert
B. has a clean, well-groomed coat
C. is not eating/drinking
D. eats its own feces

A

C. is not eating/drinking

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7
Q

During the handling of wild-caught rodents in the UK, which one of the following is a potential zoonotic risk to the handler?
A. Toxoplasmosis
B. Leptospirosis
C. Rabies virus
D. Mouse hepatitis virus

A

B. Leptospirosis

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8
Q

Which of the following is indicative of pain/distress in a group housed rodent?
A. Inquisitive when approached
B. Tries to avoid capture
C. Isolation from other members of the group
D. Warm to touch

A

C. Isolation from other members of the group

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9
Q

Piloerection is a common sign of pain in animals, which is:
A. Raised guard hairs leading to staring coat
B. Sunken eyes
C. Reduced circulation, resulting in loss of colour at extremities
D. Holding a limb erect in a protective manner

A

A. Raised guard hairs leading to staring coat

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10
Q

Schedule 1 euthanasia of adult rats and mice may be carried out by exposure to:
A. A rising concentration of CO2
B. A 50:50 mixture of O2 and CO2
C. A 75% mixture of CO2
D. A 100% concentration of CO2

A

A. A rising concentration of CO2

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11
Q

Behavioral observations are important for monitoring pain and distress in animals. For these to be useful recognition of changes depend upon:
A. Familiarity with the normal activity of that species and strain
B. Measurement of physiological parameters E.g. HR, BP
C. Observation of changes after the animal has received an analgesia
D. Familiarity with normal activity in other species

A

A. Familiarity with the normal activity of that species and strain

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12
Q

Who has responsibility for safety in an animal facility?
A. All individuals using the facility
B. The project license holder
C. The nACWO
D. The Home Office Inspector

A

A. All individuals using the facility

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13
Q

Of the following, which would be the most common cause of laboratory animal allergy?
A. Exposure to animal blood
B. Animal bites or scratches
C. Exposure to airborne dander
D. Exposure to animal saliva

A

C. Exposure to airborne dander

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14
Q

A zoonotic disease:
A. Only occurs in laboratory animals
B. Is transmissible from animals to human
C. Is transmissible from one laboratory animal species to another
D. Is an allergic response to animal proteins

A

B. Is transmissible from animals to human

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15
Q

Which of the following is a suitable inhalation anaesthetic for rodents?
A. Isoflurane
B. Chloroform
C. Nitrous oxide
D. Ether

A

A. Isoflurane

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16
Q

A laboratory animal of undefined health status is commonly referred to as:
A. Ordinary
B. SPF
C. Conventional
D. Hybrid

A

C. Conventional

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17
Q

The purpose of administering a sedative prior to a minor procedure is:
A. Allay fear and anxiety
B. Increase drug metabolism
C. Reduce recovery time
D. Reduce hypothermia risk

A

A. Allay fear and anxiety

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18
Q

Drugs reach the circulation most quickly if given:
A. Orally
B. SC
C. IP
D. IV

A

D. IV

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19
Q

In rodents, IP injections should be given:
A. In the midline caudal (lower) abdomen
B. In the lower left or right quadrant of abdomen
C. Into liver
D. Into skin on flank with animal held upright

A

B. In the lower left or right quadrant of abdomen

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20
Q

When maintained w/ lights on from 5-19:00 hours, rats and mice are expected to consume most of their food and water requirements between:
A. 5-13:00
B. 14:00-17:00
C. 18:00-22:00
D. 1:00-8:00

A

D. 1:00-8:00

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21
Q

The normal range for relative humidity in a room housing rodents is:
A. 25-45%
B. 45-65%
C. 65-85%
D. >80%

A

B. 45-65%

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22
Q

The recommended optimum temperature range for housing rats, mice, and hamsters is:
A. 16-22
B. 18-22
C. 19-23
D. 15-24

A

C. 19-23

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23
Q

Which of the following organisms are a common cause of skin disease in laboratory rodents?
A. Mycoplasma
B. Ringworm
C. Leptospira
D. Protozoa

A

B. Ringworm

24
Q

Under what circumstances can scientific procedures under terminal anaesthesia be performed WITHOUT a personal license?
A. Always, because a personal license isn’t required for procedures performed solely under terminal anaesthesia
B. When the procedures are performed by a project license holder
C. When the procedures are performed by the named veterinary surgeon
D. Never, because a personal license is always required for procedures performed under terminal anaesthesia

A

D. Never, because a personal license is always required for procedures performed under terminal anaesthesia

25
Q

Permission to use a NMB agent must be obtained from:
A. Secretary of State for Home Office
B. Named Vet
C. Establishment’s certificate holder
D. relevant Project license holder

A

A. Secretary of State for Home Office

26
Q

One reason that ether is no longer considered a suitable agent for anaesthetizing rodents is that it
A. Induces hyperactivity on recovery
B. Is very expensive
C. Is irritant
D. Is carcinogenic

A

C. Is irritant

27
Q

Which gas is normally used as the carrier gas when an anesthetic machine is used to administer inhalational anesthesia?
A. CO2
B. O2
C. Nitrogen
D. Nitrous oxide

A

B. O2

28
Q

When administering substances IM, particular care should be taken to avoid damage to the:
A. Bone
B. Blood vessels
C. Skin
D. Fat

A

B. Blood vessels

29
Q

The best practice for administering a gaseous agent to induce anaesthesia in a rodent is:
A. via face mask
B. In an anaesthetic chamber
C. Using a scavenging unit
D. Via an endotracheal tube

A

B. In an anaesthetic chamber

30
Q

You enter an animal room and after handling rats your eyes are running and your nose is itching. What should you do?
A. Obtain some personal protective equipment, such as a face mask and continue working
B. Leave the animal unit and report the problem to the occupational health physician
C. Ignore the problem and continue working
D. Wash your face and carry on working

A

A. Obtain some personal protective equipment, such as a face mask and continue working

31
Q

Which of the following will help the most to reduce the level of allergens in an animal room?
A. Local exhaust systems from animal cages
B. Leaving the door open
C. Sweeping the floor regularly
D. Mopping the floor regularly

A

A. Local exhaust systems from animal cages

32
Q

Which of the following signs might you encounter in a guinea pig in pain?
A. Reluctant to move when group disturbed
B. Squeals when handled
C. Runs away quickly when group disturbed
D. Warm to touch

A

A. Reluctant to move when group disturbed

33
Q

How might you recognize evidence of dehydration in rodents?
A. Piloerection
B. Hair loss
C. Excessive grooming
D. Loss of skin elasticity

A

D. Loss of skin elasticity

34
Q

Which of the following methods of killing appears on Schedule 1 of the ASPA and can be used by competent people to kill protected animals at designated establishments?
A. Dislocation of the neck for all species up to 2kg
B. Overdose of appropriate anesthetic followed by exsanguination for all animals
C. Cooling followed by immersion in cold tissue fixative, for animal mice and rats
D. Decapitation, for rabbits

A

B. Overdose of appropriate anesthetic followed by exsanguination for all animals

35
Q

Chromodacryorrhoea is a common sign of stress in a rat. It is:
A. Slow/shallow breathing
B. Scouring/staining in ano-genital area
C. The colour change from pink to blue/purple in skin/membranes
D. Red staining around eyes and nose

A

D. Red staining around eyes and nose (porphyrin)

36
Q

The correct way to carry a loaded syringe is:
A. Loose with the needle attached and uncovered
B. On a tray with the needle attached and recovered
C. Loose with needle attached and recovered
On a tray with a new needle attached

A

B. On a tray with the needle attached and recovered

37
Q

Which of the following statements are correct?
A. Inhalation anaesthetics must be administered using a specially designed vaporiser
B. Inhalational anaesthetics cannot be administered to birds
C. Ether is a safe, non-irritant anaesthetic agent
D. Nitrous oxide will produce surgical anaesthsia in most animal species

A

A. Inhalation anaesthetics must be administered using a specially designed vaporiser

38
Q

In combination with monitoring other vital signs, which of the following is the most useful in assessing the depth of anaesthsia in rodents?
A. Testing for the presence of a pedal withdrawal reflex
B. Noting the colour of the mucous membranes
C. Counting the heart rate
D. Measuring the rate of urine formation

A

A. Testing for the presence of a pedal withdrawal reflex

39
Q

The upper limit of human hearing is 20kHz. What is it for rodents?
A. 1kHz
B. 10kHz
C. 20kHz
D. 80kHz

A

D. 80kHz

40
Q

A laboratory mouse at weaning weighs approx:
A. 1-5g
B. 10-15g
C. 20-25g
D. 30-35g

A

B. 10-15g

41
Q

Visible evidence that copulation has recently occured in mice is the presence of:
A. Changes in behaviour
B. Oestrus
C. Vaginal plug
D. Ovulation

A

C. Vaginal plug

42
Q

Mammals are endotherms. What does this mean?
A. They are able to eat animal and vegetable material
B. They sustain their young by producing milk
C. They carry their young in a pouch
D. They can control their body temperature by physiological means

A

D. They can control their body temperature by physiological means

43
Q

Which of the following inhalation anaesthetic agents is flammable and rarely used?
A. Isoflurane
B. Diethyl ether
C. Enflurane
D. Halothane

A

B. Diethyl ether

44
Q

The average daily water intake of a healthy adult rat is:
A. 10ml/100g body weight
B. 20ml/100g body weight
C. 30ml/100g body weight
D. 40ml/100g body weight

A

A. 10ml/100g body weight

45
Q

For animals bred under “Full SPF Barrier” conditions, which of the following statements is correct?
A. They are free from all micro-organisms
B. They are free from specified organisms
C. They are provided with conditioned air
D. They are exposed to no micro-organisms

A

B. They are free from specified organisms

46
Q

Sub-clinical infection:
A. Produces minor clinical signs
B. Cannot affect experimental results
C. Cannot spread to other animals
D. Produces no overt clinical signs

A

D. Produces no overt clinical signs

47
Q

Environmental enrichment:
A. Can have a positive effect on animals welfare
B. Should not come in contact with animals
C. Should only be given to breeding animals
D. Can adversely affect experimental results

A

A. Can have a positive effect on animals welfare

48
Q

What is oral gavage?
A. Dosing into the stomach by an oral gastric tube
B. Dosing into the stomach by injection through the stomach wall
C. Giving a substance via the food or water
D. Creating an indwelling gastric catheter

A

A. Dosing into the stomach by an oral gastric tube

49
Q

What is the optimum relative humidity range for rodents?
A. 100%
B. 85%
C. 55%
D. 25%

A

C. 55%

50
Q

Is this an appropriate method of sterilizing surgical instruments for aseptic surgery?
Steep in alcohol for 5 minutes

A

False

51
Q

Is this an appropriate method of sterilizing surgical instruments for aseptic surgery?
Rinsing in sterile saline

A

False

52
Q

Is this an appropriate method of sterilizing surgical instruments for aseptic surgery?
Wash in a dishwasher

A

False

53
Q

When lifting a mouse from a cage for examination, you should:
A. Press it to the floor of the cage with your hand
B. Lift by the tip of the tail
C. Catch a limb with a forceps and hold it in the air to examine
D. Lift it in cupped hands

A

D. Lift it in cupped hands

54
Q

Drugs reach the circulation most slowly if given:
A. Topically on skin
B. IP injection
C. IV injection
D. SC injection

A

A. Topically on skin

55
Q

Which one of the following agents is a suitable inhalation anaesthetic for rodents?
A. Ether
B. NO
C. Isoflurane
D. Pentobarbital sodium
E. Chloroform

A

C. Isoflurane

Rodent Module (9 decks)

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