Salivary Glands: Inflammatory Disorders & Neoplasms Flashcards
What are the three types of salivary glands?
Parotid, submandibular and sublingual
What kind of saliva is secreted out of parotid glands?
Mainly serous saliva
Parotid Gland Duct
Stensen’s Duct/Parotid Papilla
Submandibular Gland Saliva Type
Mixture of serous and mucinous saliva
Submandibular Gland Duct
Wharton’s Duct; sublingual caruncles on either side of the lingual frenum
Sublingual Gland Saliva Type
Mainly mucinous saliva
Sublingual Gland Ducts
8-20 excretory ducts
Smaller Sublingual Gland Ducts; where do they exit?
Ducts of Rivinus; exit into the floor of the mouth
Major Sublingual Glands; where do they exit?
Duct of Bartholin; exits through the submandibular duct (wharton’s duct)
How many minor salivary glands are there?
600+ of them
Are minor salivary glands encapsulated?
No
Where are minor salivary glands located?
Labial mucosa, buccal mucosa, palate, tongue
Describe Minor salivary glands located on tongue
Anterior and posterior
Von Ebner’s Glands produce serous saliva surrounding circumvallate papillae
Where are minor salivary glands not located?
Anterior hard palate and gingiva except retromolar pad
Salivary Glands are composed of what three structures?
Secretory component+ ducts+ myoepithelial cells
Salivary Gland Structure: Describe what makes up secretory component
Serous, mucous or both serous and mucous saliva
Salivary Gland Structure: Describe serous cells
Protein secreting, from acinar structures, think less saliva
Salivary Gland Structure: Describe mucous cells
Secrete mucin, usually tubular strcuture rather than acini, think more viscous saliva
Salivary Gland Structure: Describe serious demilunes
Mixed serous and mucous acinus, serous cells surrounding mucous acinus
Salivary Gland Structure: Describe duct system
Intercalated duct -> striated duct -> excretory duct
Salivary Gland Structure: Describe myoepithelial cells
Surround acini and intercalated ducts, contract to help move secretory products
List Salivary Gland DIsorders
Mucocele Ranula Salivary Duct Cyst Necrotizing Sialometaplasia Sialolithiasis Sialadenosis Sialadenitis Sjogren's Syndrome
Mucocele Clinical Presentation
Dome-shaped swelling, compressible, non-painful (frequently) blush
Mucocele Etiology
Trauma to a salivary gland duct causing extravasation of mucin into adjacent tissue
Mucocele Location
Lower labial mucosa»_space; floor of mouth (ranula) > anterior ventral tongue, buccal mucosa, palate, retromolar pad
In what oral site will a mucocele never occur?
Gingiva
Mucocele Population
Any age, but usually younger patients as a results of increased prevalence of trauma
Mucocele Histology
Mucous surrounded by granulation tissue wall
Mucocele Treatment
Conservative excision of lesion+ surrounding minor salivary gland lobules
Mucocele Excision Techniques
Elipse, Enucleation, laser ablation
Muocele Recurrence
Remove adjacent minor salivary gland lobules to prevent recurrence
Mucocele: Clinical Variant
Superficial Mucocele
Superficial Mucocele Common Sites
Soft palate, retromolar pad, posterior buccal mucosa
Superficial Mucocele Treatment
Ruptures and leave shallow painful ulcers -> do not require excision
Superficial Mucocele may develop in associate with what other conditions?
Lichen Planus, lichenoid drug eruption, or GVHD
Describe a Ranula
Mucocele of the floor of the mouth
Where do Ranulas occur?
Sublingual gland
Ranula Treatment
Marsupialization
Removal of lesion along with the sublingual gland
Why may marsupialization not be successful with ranulas?
Larger lesions
Ranula Clinical Variant & Significance
Plunging Ranula (cervical ranula)
What occurs with a plunging ranula (cervical ranula)?
Spilled mucin dissects through the mylohyoid muscle
What may plunging ranula be present as?
Only a neck swelling
What is used to diagnose plunging ranula?
MRI/CT
Plunging Ranula Radiographic Hallmark
Tail Sign
Define Tail Sign
Extension of the lesion into the sublingual space on imaging
Salivary Duct Cyst: Clinical Presentation
Typically soft, mucosal swelling
Color: Ranges from bluish to amber
Salivary Duct Cyst: Etiology
Ductal obstruction from sialolith or mucous plug
Salivary Duct Cyst: Location
- Any major or minor salivary glands
- Major: Parotid most common
- Minor: FOM>Buccal mucosa> lip
Salivary Duct Cyst: Population
Adults
Components of a Salivary Duct Cyst
- Lumen
- Fibrous Connective Wall
- Epithelium
Salivary Duct Cyst Treatment
- Conservative Excision
- Should not recur
Necrotizing Sialometaplasia Clinical Presentation
Swelling (1 week) -> ulceration (2 weeks) -> healing (5-6 weeks)
Necrotizing Sialometaplasia: Etiology
Ischemia, local infarction from trauma and dental injections
Necrotizing Sialometaplasia:Location
Almost always on the palate (75%)
Necrotizing Sialometaplasia: Population
Adults, male (2:1)
Necrotizing Sialometaplasia: Histology
- Acinar necrosis
- Squamous metaplasia
Describe squamous metaplasia
Cuboidal epithelium of ducts changes to squamous epithelium
Necrotizing Sialometaplasia: Treatment
- Self limiting
- Follw up and ensure complete resoultion
- If the lesion does not resolve in typical 5-6 week span you must biopsy
Sialolithiasis aka
Salivary Stones
Sialolithiasis Clinical Presentation
Episodic pain and/or swelling
Sialolithiasis Etiology
Deposition of calcium salts around a nidus of debris within the lumen of a salivary gland duct
SIalolithiasis Location
Any salivary gland (duct or within the gland itself)
Sialolithiasis: Most common major gland site; why?
Submandibular gland; long tortuous upward path
Sialolithiasis: most common minor gland site
Upper lip, buccal mucosa
Sialolithiasis Population
Most common in young and middle-aged adults
Sialolithiasis: Treatment for Minor gland stone
Excision of stone and associated minor gland
Sialolithiasis: Treatment for Major Salivary Gland Stone
- Promote passage of stone by massage of gland, moist heat+ increased salivary flow (increased fluid intake, sour candy)
- Surgical Excision: May require partial or complete excision of the gland in some cases
Define “Sial”
Denoting saliva or salivary glands
Define “-adenitis”
Inflammation of a gland
Define “-adenosis”
Non-inflammatory enlargement of glands
Sialadenosis: Define
Non-inflammatory salivary gland enlargement
Sialadenosis: Clinical Presentation
Slowly evolving enlargement of the salivary glands
Sialdenosis: Etiology
Underlying systemic condition
- Diabetes Mellitus
- Bulimia
- Alcoholism
- Malnutrition
Sialadenosis: Location
parotid gland> submandibular > minor salivary glands
Usually bilateral