Saliva 2 Flashcards
Describe the general structure of the secretary end piece….
Comprised of a cluster of acinar cells surrounding a central lumen.
The cells of the end piece are joined together by ______ which allow the passage of ______ & ____, but not _____.
Tight junctions, allow water and small ion passage, but not larger molecules.
______ Surrounds the Acinar cell.
Myoepithelial cell
The entire end piece is surrounded by _____.
Basal lamina
Describe the 6 structural aspects of a Serous Cell.
- Pyramidal in shape
- Rest on basal lamina
- Short irregular microvilli
- Exhibit many characteristics of polarized protein secreting cells.
- Secrete many enzymes and glycoproteins
- Protein machinery is well defined (golgi app. RER….)
Describe the 5 Structural aspects of a Mucous cell.
- Cuboidal to columnar shaped
- Oval nuclei pressed toward base (and flatten/squished)
- Arranging in tubules around a larger central lumen
- Secretes mucins (not secreted by serous cells)
- Secretory granules pale staining
What is a serous demilune?
A cluster of serous cells topping a mucous acinus
_______ surround the acinar cells & intercalated ducts, lie within the basal lamina and have multiple processes.
Myoepithelial cells
What is the function/role of the myoepithelial cells?
Has contractile properties that facilitate the expelling of salvia into the ductal system.
_____ glands have all 3 types of ducts.
Major glands
______ glands empty straight into excretory duct.
Minor glands *Never have striated ducts and only sometimes have intercalated
T or F, There are many excretory ducts for major salivary glands.
False! There are for MINOR salivary glands.
5 descriptive facts about intercalated ducts.
- Smallest duct
- Several acini drain into each intercalated duct
- Ducts are short
- Cells are cuboidal with a centrally placed nuclei
- Secrete few proteins
* Major function is to convey saliva!
8 Descriptive facts about Striated ducts.
- Longer, more active duct
- Site of resorption of sodium and chloride = turns the salvia (secondary) HYPOTONIC. *requires ATP
- Secretes Bicarbonate as buffer
- Columnar cells
- Highly polarized
- Short microvilli
- Prominent mitochondria
- Numerous infoldings of the basolateral membrane!!!
What is the purpose of Excretory/collecting duct?
Carrying salvia to oral cavity * series of connecting ducts that get wider and wider.
- Descriptive facts about Excretory/collecting ducts.
- No secretion or resorbtion
- ducts get progressively wider
- As they get closer to oral cavity epithelium changes from single layer to pseudo stratified, to stratified to keratinized.
______ sometimes intermingle with excretory duct cells.
Goblet cells = secrete mucins
The sublingual gland is ______ but Primarily ______.
Mixed, but primarily mucous.
The submandibular gland is ____, but primarily ______.
Mixed, but primarily serous.
Most of the minor salivary glands are _______.
Nearly/pure mucous
Von Ebners glands found where?
Posterior of tongue, Foliate and Cirvumvallate papilla.
Von Ebners glands are _____ glands
Pure serous (Major lipase secretor)
With age general loss of parenchyma can = _____%
30-60% = Does not automatically = dry mouth
Hyposalviation is defined as _____.
What are some treatments for Hyposalivation?
Artificial saliva
Frequent dental exams
Salivary stimulants (gum, candies)
______ can stimulate salivary flow, but their side effects can be prohibitive.
Muscarinic cholinergic agonists
