Salicylates Flashcards
what is aspirins chemical name?
acetylsalicyclic acid or ASA
what is the chemical structure of aspirin?
a benzene ring with COOH and OCOCH3 is the 1,2 postions
what is the half life of aspirin?
t 1/2=20-30 minutes
does aspirin cross the blood brain barrier?
yes, that’s why it relieves headaches
what is aspiring converted to in a water environment?
salicyclic acid and acetic acid
how do you treat an aspirin overdose
give them some sort of base, usually bicarbonate
what happens to aspirin (acetyl salicylic acid) to make it part of an irreversible reaction?
acetylation of NH2 terminal serinve of cyclooxygenase (irreversible)
NFkB (k=kappa)
a major player, during an inflammatory response, in tissue damage. Aspirin and salicyclic acid inhibit induction of this
what molecule does aspirin inhibit in order to reduce fever, and where does it occur? (antipyretic)
it inhibits PgE2 in the hypothalamus
the four A’s of NSAIDs
- antiinflammatory
- antipyretic (fever reducing)
- analgesic (relieve pain)
- antithrombotic
which prostaglandin increases the sensation of pain?
PGE2
what is aspirins effect on respiration, and why?
especially in higher doses, it makes you breath faster and deeper bc of “uncoupling oxidative phosphorylation,” this is also typical of acidosis, bc of the increased respiration, the body excretes more Na and K excretion. This could kill someone
remember the signs of aspirin overdose and the treatment
the increase in breathing frequency and depth, treat with bicarbonate and cardiovascular and respiratory support
Reye’ssyndrome
-hepatic failure in children that were given aspirin for a fever, chicken pox or influenze. Need to use acetaminophen instead
mild chronic salicylate intoxication
Salicylism
-headache, dizziness, tinnitus, difficulty hearing, dim
vision, mental confusion, lassitude, drowsiness, sweating, thirst, hyperventilation, nausea, vomiting and occasionally
diarrhea.
