Salicylate Overdose

Question 1

What meds is an example of a Salicylate?

Answer 1

Aspirin

Question 2

What Phenomena does a Salicylate overdose lead to? (2 things)

Answer 2

1. Resp Alkalosis (comes first)
2. Met Acidosis

Question 3

How does Salicylate overdose cause Resp Alkalosis?

Answer 3

Early stimulation of Resp centre

Question 4

How does Salicylate overdose cause Met Acidosis? (2 things)

Answer 4

1. Direct acid fx of Salicylates
2. Acute renal failure

Question 5

Which phenomena of Salicylate overdose dominates in kids?

Answer 5

Met acidosis

Question 6

What are the CF of Salicylate overdose? (8 things)

Answer 6

1. Lethargy
2. Coma
3. Seizures
4. Sweating
5. Tinnitus
6. N + V
7. Hyperventilation
8. Hyperglycaemia / Hypoglycaemia

Question 7

What are the GENERAL Mx options for Salicylate overdose? (2 things)

Answer 7

1. ABC
2. Activated charcoal

Question 8

What are the SPECIFIC Mx options for Salicylate overdose? (2 things)

Answer 8

1. Urinary alkalinisation w IV HCO3
2. Haemodialysis

Question 9

How does Urinary alkalinisation w IV HCO3 work in Mx of Salicylate overdose?

Answer 9

Enhances aspirin elimination in urine

Question 10

What are the indications for Haemodialysis for Salicylate Overdose? (5 things)

Answer 10

1. Serum conc 700+
2. Met acidosis resistant to Tx
3. Acute renal failure
4. Pulm oedema
5. Seizures / Coma