SACCM 17: Hypoventilation Flashcards
What are 3 categories of causes for hypercapnia?
- hypoventilation
- increased CO2 production e.g., fever
- increased dead space
Minute ventilation equation
VE = VT x RR
Alveolar ventilation equation
VA = VE - VD
Tidal volume equation
VT = VD + VA
What is the location of the anatomic dead space?
respiratory system down to the level of the terminal bronchioles
What is alveolar dead space?
part of the alveoli that is ventilated but does not participate in gas exchange/not perfused
< 5% normally
What is the physiologic dead space?
sum of anatomic and alveolar dead space
How do you determine anatomic dead space?
Fowler’s method
measures exhaled nitrogen after giving breath with 100% O2 -> nitrogen cc graphically displayed over time against volume exhaled
-> can derive dead space from this graph
How can you calculate physiologic dead space in a clinical setting
Enghoff modification of the Bohr equation
Explain the Bohr equation for physiologic dead space and its limitations
concept: CO2 comes from airway participating in gas exchange (i.e., not dead space) -> alveolar versus expired CO2 difference should demonstrate dead space
VT x FECO2 = (VT - VD) x FACO2 -> rearrange to:
VD/VT = (FACO2 - FECO2) / FACO2
limitations: FACO2 difficult to measure and alveolar CO2 different in part of lungs
Explain how the Enghoff modification is applied and what are its limitations
Alveolar CO2 difficult to measure -> PaCO2 as surrogate -> mixed product of all lung fields -> more representative of average CO2 of all alveoli
VD/VT = (PaCO2 - ETCO2) / PaCO2
limitations: influenced by reasons for PaCO2 - PACO2 gap, e.g., diffusion impairment, intrapulmonary shunt, V/Q mismatch
how do you determine the alveolar dead space
substract the Fowler (anatomic) dead space from the Bohr/Enghoff (physiologic) dead space
PACO2 is directly proportional to ________ and inversely proportional to __________
PACO2 is directly proportional to PACO2 produced and delivered to lungs and inversely proportional to alveolar ventilation
What PaCO2 levels are consistent with hyper- or hypoventilation
hyperventilation < 30-35 mm Hg
hypoventilation > 40-45 mm Hg
How does PvCO2 compare to PaCO2?
PvCO2 generally 3-6 mm Hg higher than PaCO2