SAC 1 Flashcards
what is an action potential?
a neuron has a resting potential when not activated. negatively charged ions are inside the neuron and negatively charged ions are outside. all or nothing process
what are neurotransmitters
are a chemical substance produced by a neuron that carry a message to other neurons or cells in muscles, organs or other tissue. are around 50 types
role of neurotransmitters
- work by attaching or binding to receptor sites located on the dendrites of the post synaptic neuron
- they work to either excite the neuron to fire or inhibit the neuron from firing
excitatory neurotransmitters
increase to chance of an action potential firing and stimulate a response
two important excitatory neurotransmitters
glutamate: essential for memory forming and learning and excessive amounts can cause overexcitement of neurons leading to neural damage
dopamine: important for drive, motivation and motor movement
inhibitory neurotransmitters
restrict an action potential from firing therefore possibly inhibiting a response
two inhibitory neurotransmitters
GABA: when in low levels is linked to high anxiety and is essential for motor control and vision
serotonin: important for stabilising mood
CNS
central nervous system; made of brain and spinal cord. processes, organises and responds to stimuli
PNS
peripheral nervous system; made of somatic and autonomic. is a network of nerves that transmit info from muscles, glands and organs to CNS and back. Autonomic system has sympathetic and parasympathetic branches
role of axon + terminal buttons
axons transmit chemical impulses along the neuron in the form of an action potential. terminal buttons release the neurotransmitter
role of soma + myelin
soma is largest part of neuron, controls metabolism and matenience of the cell. Myelin is the white fatty coating that speeds up the message along the axon
parkinsons disease
is a neurodegenerative disease characterised by motor and non motor symptoms. effects the basal ganglia and the pre motor and primary motor cortex
cause of parkinsons + treatments
neurons in the substantia nigra degenerate meaning they do not produce dopamine sufficiently enough to support smooth motor movement. main treatment is L-DOPA which is a synthesised neurotransmitter
subtanstia nigra
basal ganglia
idiopathic
substantia nigra is a midbrain structure composed of nerve cells that produce dopamine and are associated with motor control
basal ganglia are clusters of nerve cells that regulate motor control
idiopathic means no known cause
symptoms of parkinsons
primary motor: tremors, bradykinesia, rigidity
secondary motor: reduced control of expressions, pain in limbs, swallowing problems
non-motor: embarrassment, anxiety, depression
agonist
drug that increases the uptake or release of a neurotransmitter. e.g dopamine agonist is levodopa cause it increases the chance of dopamine being taken up
antagonist
inhibits release of neurotransmitters or blocks the effect of them and makes receptor sites less likely to fire. e.g anti-psychotic drugs
alzheimers
an irreversible and progressive neurodegenerative disease that gradually kills brain cells and results in death. due to lack of acetylcholine
cause of Huntington’s and motor neuron disease
h = decrease in GABA m = imbalance of glutamate