Sabiston Esophagus Flashcards

1
Q

Esophagus Coarse

A

-The cervical esophagus begins as a midline deviates slightly to the left of the trachea as it passes through the neck into the thoracic inlet

-At the level of the carina, it deviates to the right to accommodate the arch of the aorta.

-It then winds its way back under the left mainstem bronchus and remains slightly deviated to the left

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2
Q

Killian triangle

A

-The inferior pharyngeal constrictor muscle is composed of two consecutive muscle beds—the thyropharyngeus and cricopharyngeus muscles—

-The transition between the oblique fibers of the thyropharyngeus muscle and the horizontal fibers of the cricopharyngeus muscle creates a point of potential weakness

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3
Q

The circular muscles are an extension of the

A

cricopharyngeus muscle

Then they become the middle circular muscles of the lesser curvature of the stomach

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4
Q

The collar of Helvetius

A

the transition of the circular muscles of the esophagus to oblique muscles of the stomach at the incisura (cardiac notch)

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5
Q

Three distinct areas of narrowing that contribute to its shape.

A

1-cricopharyngeus muscle is the narrowest point of the gastrointestinal tract
2-bronchoaortic constriction at the level of the fourth thoracic vertebra
3-the diaphragmatic constriction

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6
Q

The UES corresponds reliably to the

A

to the cricopharyngeus muscle

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7
Q

There are two anatomic considerations that may be used to identify the GEJ

A

1-The squamocolumnar epithelial junction (Z-line)
2-The transition from the smooth esophageal lining to the rugal folds of the stomach may also identify the GEJ

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8
Q

Externally

A

1-the collar of Helvetius (or loop of Willis), where the circular muscular fibers of the esophagus join the oblique fibers of the stomach
2-the gastroesophageal fat pad

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9
Q

Blood Supply to Esophagus

A

-The cervical esophagus > inferior thyroid arteries > branch off of the thyrocervical trunk on the left and the subclavian artery on the right

-The cricopharyngeus muscle, marks the inlet of the esophagus > superior thyroid artery.

-The thoracic esophagus four to six esophageal arteries coming off the aorta + branches off the right and left bronchial arteries + descending branches off the inferior thyroid arteries, intercostal arteries, and ascending branches of the paired inferior phrenic arteries.

-The abdominal esophagus > the left gastric artery and paired inferior phrenic arteries.

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10
Q

Venous Drainage of Esophagus

A

-submucosal venous plexus is the first basin for venous drainage
-cervical esophagus > the submucosal venous plexus drains into the inferior thyroid veins

-The thoracic esophagus > submucosal venous plexus joins with the more superficial esophageal venous plexus and the venae comitantes > drains into the azygos(RT) and hemiazygos(LT) veins

-The intercostal veins > drain into the azygos venous system.

-The abdominal esophagus > systemic and portal venous systems through the left and right phrenic veins and left gastric (coronary) vein and short gastric veins

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11
Q

The superior laryngeal nerve

A

external : motor innervation to the inferior pharyngeal constrictor muscle and cricothyroid muscle

internal : sensory innervation to the larynx

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12
Q

recurrent laryngeal nerves

A

right : loop underneath the right subclavian

left : loop underneath the aortic arch

then travel upward in the tracheoesophageal groove to enter the larynx laterally underneath the inferior pharyngeal constrictor muscle.

innervate the cervical esophagus, including the cricopharyngeus muscle

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13
Q

three types of esophageal contractions

A

-Primary peristaltic contractions : progressive and move down the esophagus at a rate of 2 to 4 cm/sec

-Secondary : also progressive but are generated from distention or irritation of the esophagus rather than voluntary swallowing.

-Tertiary contractions : nonprogressive, nonperistaltic, monophasic or multiphasic

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14
Q

esophageal motility disorders have been classified into primary and secondary causes

A

Primary : achalasia, diffuse esophageal spasm (DES), nutcracker (jackhammer) esophagus, hypertensive LES, and ineffective esophageal motility (IEM).

Secondary : from progressive damage induced by an underlying collagen vascular or neuromuscular disorder;

scleroderma, dermatomyositis, polymyositis, lupus erythematosus, Chagas disease, and myasthenia gravis

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15
Q

Diffuse(Distal) Esophageal Spasm

A

-Manifested in a similar fashion to achalasia
-Motor abnormality of the esophageal body
- Muscular hypertrophy and degeneration of the branches of the vagus nerve
-Contractions are repetitive, simultaneous, and of high amplitude.
- Regurgitation of esophageal contents and saliva is common
-acid reflux can aggravate the symptoms.
-gallstones, peptic ulcer disease, and pancreatitis, all trigger DES
-corkscrew esophagus or pseudodiverticulosis on an esophagram
-A distal bird beak narrowing of the esophagus

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16
Q

Nutcracker Esophagus

A

-characterized by excessive contractility
-is the most common of all esophageal hypermotility disorders
-most painful of all esophageal motility disorders.
-An esophagram may or may not reveal any abnormalities

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17
Q

EGJ outflow obstruction (Hypertensive Lower Esophageal Sphincter)

A

-evidence of effective peristalsis that is not present in achalasia
-diagnosis by manometry with a hypertensive, poorly relaxing sphincter
-esophagram may show narrowing at the GEJ with delayed emptying and abnormalities of esophageal contraction

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18
Q

progressive Achalasia leads to

A

aspiration
Pneumonia
lung abscess
bronchiectasis

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19
Q

Achalasia is also known to be a premalignant condition

A

Squamous cell carcinoma (SCC) is the most common type

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20
Q

Feature of Achalasia on Esophagogram or xray

A

-Lack of a gastric air bubble is a common finding

advanced stage of disease > massive esophageal dilatation, tortuosity, and sigmoidal esophagus (megaesophagus)

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21
Q

Esophagectomy is considered in Achalasia

A

in any symptomatic patient with a tortuous dilated esophagus (megaesophagus)
sigmoid esophagus
failure of more than one myotomy
or reflux stricture that is not amenable to dilatation

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22
Q

megaesophagus Sx

A

total esophagectomy incorporating a transthoracic dissection may be safest

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23
Q

Use of POEM

A

may obviate the need for esophagectomy in this malnourished, often high-risk, patient population.

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24
Q

Diverticular Disorders

A

The three most common sites of occurrence are

pharyngoesophageal (Zenker)
parabronchial (midesophageal)
epiphrenic (supradiaphragmatic)

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25
Q

false pulsion diverticula

A

Zenker diverticulum and an epiphrenic diverticulum

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26
Q

Traction, or true, diverticula

A

-from external inflammatory mediastinal lymph nodes pulling the esophagus

-more common in the midesophageal region around the carinal lymph nodes

27
Q

The most serious complication from an untreated Zenker diverticulum

A

is aspiration pneumonia or lung abscess.

28
Q

Dx of Zenker

A

Lateral views are critical because this is usually a posterior structure.

29
Q

small diverticulum (<2 cm)

A

myotomy alone is often sufficient

patients with good tissue or a large sac (>5 cm), excision of the sac is indicated

30
Q

Midesophageal Diverticula

A

-inflamed mediastinal lymph nodes tuberculosis accounted for most cases

-histoplasmosis and resultant fibrosing mediastinitis have now become more common

31
Q

Midesophageal diverticula Approach

A

-barium esophagram > typically are on the right
-CT scan > identify any mediastinal lymphadenopathy
-Endoscopy > rule out mucosal abnormalities identifying a fistula.
-Manometric studies > identify a primary motor disorder.

Treatment is guided by the results of the manometric findings

32
Q

midesophageal diverticula Tx

A

-treatment of the underlying cause is the management of choice.
-diverticulum smaller than 2 cm can be observed.
-If patients progress to become symptomatic or diverticulum 2 cm or larger, surgical intervention is indicated

33
Q

Epiphrenic Diverticula

A

-in the distal third of the esophagus, within 10 cm of the GEJ.
-related to thickened distal esophageal musculature or increased intraluminal pressure
-associated with DES, achalasia, or hypertensive LES disorders.
-If no motility abnormality > congenital (Ehlers-Danlos syndrome) or traumatic cause is considered.

-As with midesophageal diverticula, epiphrenic diverticula are more common on the right side

34
Q

epiphrenic diverticulum Tx

A

Small (<2 cm) diverticula can also be suspended from the vertebral fascia and need not be excised.

If a diverticulopexy is performed, a myotomy is begun at the neck of the diverticulum and extended onto the LES.

If a diverticulectomy is pursued, a vertical stapling device is placed across the neck and the diverticulum is excised

35
Q

basic tenets of antireflux surgery

A

(1) preserve natural tissue planes and linings
(2) identify and preserve both vagus nerves
(3) identify the true EGJ for placement of the wrap
(4) have sufficient length of intraabdominal esophagus
(5) reestablish the angle of His

36
Q

in Gerd Sx A consideration for patients with bile or gastric reflux, morbid obesity, diabetes, or esophageal dysmotility

A

is Roux-en-Y reconstruction

37
Q

Caustic Ingestion

A

1-examination findings of upper airway
2-bronchoscopic guidance for ETT and preparation to perform cricothyroidotomy
3- CT scan of chest and abdomen with intravenous and oral administration of contrast followed by a barium swallow study
4-endoscopic evaluation > done early in the hospital course as the risk of perforation increases after 48 hours. Pediatric endoscopes are useful
should not proceed past an area of circumferential injury

38
Q

endoscopic findings

A

see

39
Q

Schatzki ring

A

-Nonmalignant, fibrous thickening and narrowing of the GEJ
-Concomitant finding of hiatal hernia
-Tx dilatation (bougie or balloon)
-Bx to rule out malignancy.
-Repeated dilatation often necessary
-Persistent strictures suspicion for malignant disease

40
Q

Benign Tumors of the Esophagus

A

-Granular cell tumors :
from Schwann cells
mucosa or submucosa
distal third of the esophagus
Tunneled biopsies : eosinophilic granules
stain positive for S100,
Atypical features on EUS, large (>2 cm), symptomatic > reasonable indications for excision

41
Q

Fibrovascular polyps

A

-cervical esophagus at or near the cricopharyngeus
-heterogeneous group of soft tissue tumors
-cylindrical or elongated, with a stalk

42
Q

Squamous papillomas

A

-exophytic projections, wart-like
-crossing vessel on the surface
-link with (HPV)
-excision is warranted to rule out carcinoma

43
Q

Benign submucosal tumors

A

lipomas, hemangiomas, and neural tumors.

Lipomas: homogeneous, hyperechoic, smooth appearance on EUS.
Resection is seldom warranted.

Hemangiomas :purple or reddish nodule. EUS > smooth, hypoechoic, submucosal mass

Neural tumors including neurofibromas and schwannomas are rare

44
Q

Leiomyomas

A

-MC benign tumors of the esophagus.
-usually asymptomatic
-large tumors may cause dysphagia
-arise in the muscularis propria
-found in the mid to distal esophagus.
-EUS > hypoechoic, regular borders, arise from the fourth endosonographic layer.
-should not be biopsied > complicate subsequent attempts at enucleation.
-Small, asymptomatic > safely observed without biopsy.
-Symptomatic lesions > enucleated,
-large lesions > removed with a VATS approach/Endoscopic

45
Q

Rare Malignant Tumors of the Esophagus

A

-Primary melanoma of the esophagus
-Sarcomas and GISTs of the esophagus
-leiomyosarcomas

46
Q

leiomyosarcomas differentiation from Leiomyoma

A

erode through the mucosa, appearing as an ulcerated or exophytic mass on endoscopy

47
Q

GIST vs leiomyomas

A

-distinguished histologically by CD117 (c-kit) and CD34 stain positivity
-tend to be larger, with uptake of IV contrast on CT, and significant (PET) avidity.
-enucleated If negative margins can be obtained.
-Otherwise formal esophagectomy
-Imatinib > considered for any GIST larger than 3 cm or with other high-risk features.
-Imatinib > considered in the neoadjuvant setting for locally advanced tumors.

48
Q

SCC associated disorders

A

-Plummer-Vinson syndrome
-achalasia
-tylosis
-Fanconi anemia

49
Q

Tumor location by Endoscopy

A

-cervical esophagus begins at the hypopharynx and extends to the thoracic inlet, which is the level of the sternal notch.

-On endoscopy > 15 to 20 cm from the incisors.

-The upper thoracic esophagus begins at the thoracic inlet and extends to the azygos vein.

20 to 25 cm from the incisors.

-Midthoracic tumors from the lower border of the azygos vein to the inferior pulmonary vein.
25 to 30 cm from the incisors.

-Lower tumors arise distal to the lower border of the inferior pulmonary vein to the GEJ.
more than 30 cm from the incisors.

50
Q

When to Do Bronchoscopy for Esophageal CA

A

performed for proximal and middle third esophageal tumors to assess for direct tracheal invasion

51
Q

When is EMR better than EUS

A

superficial tumors (T1a–T2)
the accuracy of EUS is significantly diminished and EMR provides the most accurate staging information

52
Q

American College of Gastroenterology guidelines for low-grade dysplasia and HGD

A

-all patients with low-grade dysplasia undergo endoscopic eradication therapy
-yearly endoscopic surveillance being an acceptable alternative.

All patients with high-grade dysplasia should undergo endoscopic therapy if medically able to tolerate the procedure.

53
Q

One advantage of cryotherapy compared with RFA

A

cryotherapy does not require a probe to be in contact with the tissue

54
Q

Patient with failed RFA

A

cryotherapy has been used as salvage therapy

55
Q

when to repeat endoscopy after ablative therapy

A

HGD > three months after ablative therapy

LGD > 6 months after their Barrett esophagus/dysplasia is completely eradicated

56
Q

What is buried glands

A

Barrett epithelium could be hidden beneath areas of the new squamous epithelium ( after Ablative therapy )

57
Q

Endoscopic Resection Vs Ablative

A

limitation of ablative therapies :
-limited depth of penetration
-lack of definitive pathologic analysis.

patients with nodular or raised Barrett esophagus or other abnormalities suggestive of superficial invasive cancer should undergo EMR rather than ablation

58
Q

NCCN guidelines for Tis,T1a and T1b

A

-EMR ± ablation in patients with Tis and T1a

-Superficial T1b (SM1) patients with adenocarcinomas and low-risk features, endoscopic eradication is a reasonable alternative to surgery.

59
Q

Candidates for Esophagectomy

A

-High-risk T1a lesions
(larger tumors or lesions with lymphovascular invasion)

-Extensive, multifocal lesions and ulcerated tumors may also be difficult to eradicate endoscopically

60
Q

Who might benefit from induction therapy for T2N0

A

long tumors (>3 cm)
presence of lymphovascular invasion
and high-grade as clinical factors

61
Q

What can affect patient survival

A

nodal location, such as celiac axis or upper mediastinum, may significantly affect survival

62
Q

Regional LN for SCC and Adenocarcinoma

A

-adenocarcinoma located in the distal esophagus or GEJ
LN > celiac axis up to the paratracheal region

-SCC, in mid or proximal esophagus
LN > periesophageal cervical lymphadenopathy is still considered a regional disease

63
Q

Main cause of Death

A

Distant recurrence or metastatic disease

64
Q

The synergistic effect of chemoradiation combined with surgical resection

A

maximizes the chances of effectively treating both locoregional disease and potential undetectable metastases