S2L2 - Drugs only

Question 1

Afrezza

Answer 1

Inhaled insulin

Question 2

Insulin secretagogues

Answer 2

Cause insulin secretion by closing K channel - depolarizing - allowing Ca influx - stimulate insulin release
Glyburide, Glipizide and Glimepiride

Question 3

Glyburide

Answer 3

Insulin secretagogue

Question 4

Glipizide

Answer 4

Insulin secretagogue

Question 5

Glimepiride

Answer 5

Insulin secretagogue

Question 6

Meglitinide

Answer 6

Drug class of insulin secretagogue class with no sulfur structure
Repaglinide

Question 7

Repaglinide

Answer 7

Meglitinide class of insulin secretagogue with no sulfur structure

Question 8

D-Phenylalanine

Answer 8

Drug class of insulin secretagogue class with no sulfur structure
Nateglinide

Question 9

Nateglinide

Answer 9

D-phenylalanine class of insulin secretagogue with no sulfur structure

Question 10

Biguanide

Answer 10

Drug class that prevent lactic acid to glucose conversion via gluconeogenesis in the liver by inhibiting AMPK activation
Metformin

Question 11

Metformin

Answer 11

Biguanide class
Prevent lactic acid to glucose conversion via gluconeogenesis in the liver by inhibiting AMPK activation

Question 12

Thiazolidinediones

Answer 12

Drug class that regulate PPAR-gama which regulates muscle, fat and muscle tissue expression which increases insulin sensitivity by helping glucose metabolism and adipose storage 
Pioglitazone and rosiglitazone

Question 13

Pioglitazone

Answer 13

Thiazolidinedione
PPAR-gama which regulates muscle, fat and muscle tissue expression which increases insulin sensitivity by helping glucose metabolism and adipose storage

Question 14

Rosiglitazone

Answer 14

Thiazolidinedione
PPAR-gama which regulates muscle, fat and muscle tissue expression which increases insulin sensitivity by helping glucose metabolism and adipose storage

Question 15

Alpha-glucosidase inhibitors

Answer 15

Drug class that inhibit intestinal alpha-glucosidase that delays absorption of starch and disaccharides 
Acarbose and Miglitol

Question 16

Acarbose

Answer 16

Alpha-glucosidase inhibitor that inhibit intestinal alpha-glucosidase that delays absorption of starch and disaccharides

Question 17

Miglitol

Answer 17

Alpha-glucosidase inhibitor that inhibit intestinal alpha-glucosidase that delays absorption of starch and disaccharides

Question 18

Amylin analog

Answer 18

Drug class that suppresses glucagon release that causes delayed gastric emptying and anorectic effects - used in patients taking insulin that need additional therapy as injectable before meal 
Pramlintide

Question 19

Pramlintide

Answer 19

Amylin analog that suppresses glucagon release that causes delayed gastric emptying and anorectic effects - used in patients taking insulin that need additional therapy as injectable before meal

Question 20

Exenatide

Answer 20

Incretin therapy - GLP-1 analog to decrease glucagon release and increase insulin release - adjunct therapy

Question 21

Sitagliptin

Answer 21

Incretin therapy - inhibits DDP-4 to increase GLP-1 and GIP levels (to increase insulin release and decrease glucagon release) - usually comes as combination drug in one tablet