S2L1 - Drugs only Flashcards
Unfractionated heparin
Anticoagulant - works on factor Xa and IIa (thrombin)
Protamine
a weak base used for UFH reversal to neutralize the weak acid
Fondaparinux
HIT type II management
Argatroban
A direct thrombin inhibitor to work as an anticoagulant - usually in HIT type II management
Bivalirudin
A direct thrombin inhibitor to work as an anticoagulant - usually in HIT type II management
LMWH
Anticoagulant - works on Xa only
Tinzaparin
a type of LMWH - anticoagulant
Enoxaparin
a type of LMWH - anticoagulant
Dalteparin
a type of LMWH - anticoagulant
Warfarin
An anticoagulant that inhibits the vitamin K dependent synthesis of clotting factors II, VII, IX and X
Dabigatran
A novel anticoagulant
Apixaban
A novel anticoagulant
Rivaroxaban
A novel anticoagulant
PCCs
Prothrombin protein concentrate - contain various clotting factors to use when patient is bleed in response to new anti coagulant
Fibrinolytic/thrombolytic drugs
Break clots
Streptokinse
a fibrinolytic drug
tPA
AKA alteplase - a fibrinolytic drug - selective clot lysis
Reteplase
a fibrinolytic drug - selective clot lysis - usually in heart attack
Tenecteplase
a fibrinolytic drug - selective clot lysis - usually in heart attack
Urokinase
a fibrinolytic drug from human urine
Anistreplase
Streptokinase and plasminogen complex to use as a fibrinolytic drug
Aspirin
An antiplatelet drug to use to irreversibly inhibit COX1 and consequently TXA2 synthesis `
ADP antagonists
Adenosine diphosphate antagonist - Antiplatelet drug class used as alternative to aspirin - prevents GPIIb/IIIa activation preventing platelet aggregation
Ticlopidine
Adenosine diphosphate antagonist - Antiplatelet
