S19C241 - Infections and disorders of the neck and upper airway Flashcards

1
Q

Pharyngitis etiology

A

bacterial: GABHS (group A strep), mycoplasma, chlamydia
viral: rhino, mono (EBV), HIV

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2
Q

Mono triad

A
  • pharyngitis
  • fever
  • lymphadenopathy
  • up to 25% of pts will have a neg monospot in their first week of Sx, 10% will remain persistently negative
  • tx with amoxicillin causes a rash
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3
Q

GABHS - group A betahemolytic strep

A
  • in up to 15% of adult pharyngitis and 30% of children
  • incubation 2-5d, ten sore throat
  • certain strains cause rheumatic fever and glomerulonephritis
  • infxs during acute face and for one more week, if treated only infxs x24h
  • tx reduces Sx by 1d and reduces complications

-group C and group B beta-hemolytic strep does NOT need tx

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4
Q

Strep throat - Centor criteria

A
  • tonsillar exudate
  • tender anterior Cx adenopathy
  • absence of cough
  • hx of fever
  • no Abx if only one
  • if 2 present, swab and tx if positive
  • if 3 or 4 present just treat
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5
Q

Strep throat: tx

A
  • PNC is first line
  • PCN 500mg PO BID/TID x10d
  • macrolide if pnc allergic or clindamycin
  • dexamethasone if severe for sx relief
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6
Q

Diphtheria

A
  • immunizations exist
  • slow onset of mild-moderate pharyngitis
  • low, grade fever
  • gray membrane firmly adherent to tonsillar or pharyngeal surface, may extend to soft palate/larynx
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7
Q

PTA

A
  • signs: fever, malaise, sore throat, trismus, muffled voice (hot potato), swollen tonsil
  • ddx: cellulitis, mono, lymphoma, HSV, RPA, neoplasm, FB, internal artery aneurysm
  • tx: needle aspiration, tonsillectomy (rare), 10d of amox-clav 875mg BID or PCN 500mg QID plus flagyl 500mg QID
  • f/u 24h
  • consider CT
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8
Q

PTA: needle aspiration

A
  • lidocaine inhaled or spray
  • inject 1-2cc lidocain with epi into mucosa of tonsillar pillar
  • then 18g needle lateral to tonsil 1/2 way b/w base of uvula and maxillary alveolar ridge NMT 1cm deep (consider palpating first to determine location of ICA)
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9
Q

Epiglottitis

A
  • b/of Haemophilus influenza b vaccine most cases are 46yo pts
  • etiology: strep, staph, cirus, fungi, 25% are h flu still
  • sx: 1-2d of dysphagia, odynophagia, dyspnea, pain with palpation of larynx and upper trachea, inspiratory stridor, tripod position
  • 3D triad (drooling, dysphagia, distress)
  • tx: protect airway (intubate if necessarY), O2, hydrate, monitor, IV Abx, heliox, intubate with bronchoscope if possible
  • CTX 2g IV
  • others: ampicillin-sulbactam, cefotaxime, pip-tazo, steroids
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10
Q

Epiglottitis signs on xray

A
  • obliteration of vallecula
  • swelling of aryepiglottic folds
  • edema of prevertebral and retropharyngeal soft tissues
  • ballooning of hypopharynx
  • epiglottis thumb shaped and enlarged
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11
Q

RPA:

A
  • anywhere from base of skull to corina
  • adults with RPA are more likely to extend to mediastinum
  • Sx: sore throat, fever, torticollis, dysphagia
  • Dx: contrast-CT is gold standard
  • Tx: clinda 600-900mg IV or cefoxitin 2g IV or pip-tazo, most require surgical intervention
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12
Q

Odontogenic Abscess

A

-may occur

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13
Q

Ludwig Angina

A
  • infxn of submental, sublingual, submandibular spaces bilaterally
  • Sx: poor dental hygience, dysphagia, odynophagia, trismus, edema upper neck and floor of mouth
  • spreads quickly
  • need immediate definite airway mgmt as it takes >1w for edema resolution with Abx
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14
Q

Facial Necrotizing INfections

A
  • Sx: critically ill, skin discoloration, crepitus, fever, tachy, HoTN, confusion
  • CT: SC emphysema, deep tissue gas
  • Tx: surgical fasciotomy, wide debridement, Abx
  • Complications: mediastinal extension, great vessel erosion, retroperitoneal extension, pleural abscess, pericardial effusion, sepsis
  • mortality 25-40%
  • Dx: contrast CT
  • Tx: Abx and drainage (pip-tazo, imipenem)
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15
Q

Branchial Cleft Cysts

A
  • occur at any age
  • painless, fluctuant, anterior to border of anterior sternocleidomastoid muscle, may enlarge after URTI, may become infected
  • if infected they need Abx and surgical excision once infection resolved
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16
Q

Thyroglossal duct cysts

A
  • from remnants of thyroid anlage
  • anywhere midline from base of tongue to low neck, usually children, usually asymptomatic subhyoid midline neck mass
  • may enlarge after URTI and become infected
  • soft, mobile, bluish hue
  • tx: surgical excision
17
Q

Most common cause of unilateral neck mass in >40yo?

A
  • scc of upper aerodigestive tract

- metastatic to cervical lymph nodes

18
Q

Infectious lymphadenopathy

A
  • empiric tx with Abx (keflex, amoxicillin or clinda)

- should resolve w/in 2w

19
Q

Posttonsillectomy bleeding

A
  • common complication
  • usually 5-10d post-op but can occur w/in 24h
  • RF: ages 21-30yo
  • Tx: NPO, monitor, IV, CBC/coags, pressure to tonsillar bed with gauze on a clamp, moisten gauze with thrombin or 1:10,000 epinephrine and lidocaine, intubate if necessary,cauterize with silver nitrate if bleeder identifiable, refer to ENT
  • tip: suture through packing and tape to face so that no gauze is lost
20
Q

Recurrent Respiratory Papillomatosis

A
  • bimodal: ages 2mo-4y and adults >30yo
  • HPV infection
  • Sx: chronic cough, hoarseness, stridor, dyspnea
  • wart-like lesions w/o ulceration, can sometimes be seen on Soft tissue XR
  • Tx: if severe give heliox, intubate only if absolutely needed
21
Q

Clothesline injury

A
  • sudden blunt laryngeal trauma
  • crush injury to thyroid cartilage, can cause laryngotracheal separation
  • if unable to identify the tracheal lumen d/t antaomic disruption, edema or hemorrhage do not attempt intubation, do a tracheostomy (vertical skin incision, enter trachea b/w 4th/5th tracheal ring), avoid cricothyrotomy b/c may further injure the subglottis
  • Dx: CT
22
Q

Angioedema of upper airway: etiologies

A
  • congenital/acquired loss of C1 esterase inhibitor
  • IgE mediated allergic rxn
  • rxn to ACEi
  • idiopathic
23
Q

Hereditary angioedema

A
  • deficiency in C1 esterase inhibitor, results in unregulated vasoactive mediators
  • pts have recurrent episodes and abdo pain
  • usually occurs before 5yo, 75% will occur before 15yo
  • autosomal dominant
  • Dx: measure C1 and C4 levels
  • Tx: epinephrine in acute attack, FFP contains the missing inhibitor protein but may worsen a life-threatening attack, if pt is in extremis then fiberoptic intubation
  • long-term Tx: acetylated artificial androgens
24
Q

ACEi angioedema

A
  • highest risk in first month of starting ACEi but can occura t any time
  • occurs in 0.1-2.2% of pts on ACEi (blacks>whites)
  • ACEi inactivate bradykinin, can result in increased bradykinin, vasodilation and increased permeability
  • also documented in ARB
  • Tx: IV, scope if possible (may have facial edema but no laryngeal edema), epi 1:1000 SC at 0.01mg/kg (NMT 0.3mg), or inhaled racemic epi or epi-pen
  • repeat epi q15-20mins
  • gravol 50mg/kg
  • methylprednisolong 125mg IV
25
Q

Quincke edema

A
  • isolated uvula edema
  • check for associated PTA or angioedema or epiglottitis
  • if isolated then give dex 4mg IV/PO