s11 quiz lung cancer and TB Flashcards
most common lung cancer in non smokers and women?
bronchogenic adenocarcinoma
which cancers have the strongest link with smoking
small cell carcinoma (relatively uncommon)
squamous cell carcinoma
describe perfusion lung apices vs bases?
apices=less perfusion than bases
describe pH of blood at lung apices
pH higher (alkalotic)
describe pO2 lung apices vs bases
CLINICAL REL
higher at apices
mycobacterium tuberculosis growth favoured in high pO2 > apices of lungs
classic presentation of post primary TB?
- night sweats
- weight loss
- chronic cough
- productive cough (possibly)
classic CXR post primary TB
- multi nodular
- caveatting lesions
in apical segment of lungs - satellite leisions
common lobes for primary TB?
middle and lower lobes (where small infectious particles lodge)
common abnormality seen on primary TB CXR
Ghon complex
enlarged hilar lymph nodes and Gohn foci
risk factors of TB
- non UK born
- HIV
- poorly controlled type 2 diabetes
- immunocompromised (cancer)
- drug user
- close contact
- work in area where TB endemic
signs and symptoms of primary adrenocortical insufficiency?
ADDISONS
- fatigue
- progressive weakness
- poor appetite
- salt craving
- weight loss
- dizziness
- hypotension
- skin hyperpigmentation
- hypoglycaemia
- hyponatremia
list 4 first line medications for TB + their side effects
Rifampicin
• Raised transaminases & induces cytochrome P450
• Orange secretions / urine
Isoniazid
• Peripheral neuropathy (prevent with pyridoxine 10mg od)
• Hepatotoxicity
Pyrazinamide
• Hepatotoxicity
Ethambutol
• Visual disturbance
common cause of siADH?
small cell carcinoma of lung
screening age for lung cancer?
55-74yrs
