?s Miller said he would ask (Quiz 2) Flashcards
Do anxiolytics (barbituates and benzodiazepines) work on GABA receptors?
NO
Benzos + Alcohol = ?
Potential for coma and respiratory failure
How do benzos work?
They bind to their own receptor sites and then enhance the affinity of GABA receptors for circulating endogenous GABA
What is a non-benzodiazepine hypnotic that binds to GABA(a) receptors?
Zolpidem/Ambien
What drug potentiates the GABA effect on chloride ion channels by binding to receptor sites not involved with the binding of benzodiazepines?
Eszopiclone/Lunesta
Flumazenil/Romazicon indication and char?
IV used to reverse the effects of benzodiazepines. Pt may be combative after coming back.
What are sx of benzodiazepine withdrawal syndrome?
Seizures
How must a benzodiazepine overdose be treated? (administration, dosage, etc.)
Flumazenil/Romazicon
- Rapid onset (1-2 min)
- Short half life (1 hour)
- Multiple doses must be given to maintain reversal of the benzodiazepine overdose, especially long acting benzos.
Where do the neruoleptic drugs have the chief antipsychotic effects?
D2 receptors ( dopamine blockade)
What is dyskinesia?
Involuntary movement (facial grimacing and involuntary movements of limbs)
What does tardive mean?
Meaning the SE (dyskinesia in the case of anti-psychotics) continues on after the drugs are no longer being taken.
What is characterized by catatonia, fluctuating blood pressure, dysarthria and fever?
Neuroleptic malignant syndrome
What is the treatment for neuroleptic malignant syndrome?
Immediate discontinuation of antipsychotic drugs.
Dopamine agonist such as Bromocriptine.
Chlorpromazine/Thorazine MOA
D2 dopaminergic receptor site blockage
Alpha-adrenergic blockage
H1 blockade (anti-histamine)
What is a common hormonal SE associated with the use of Chlorpromazine/Thorazine?
Increased release of prolactin commonly occurs as a result of dopamine blockade.
