S&F Part II Flashcards
What is thoracic outlet syndrome?
Brachial plexus and subclavian artery run in between middle and anterior scalene and can be compressed
symptoms: tingling, numbness, restricted blood flow
causes: cervical rib, scalene compressing, clavicle compressing, etc.
Where is the retropharyngeal space and what is the significance?
Lies between prevertebral fascia and the buccopharyngeal fascia (posterior border of the pretracheal fascia)
extends from neck into chest and can facilitate the spread of infectious pus
What are the cervical nerves in the head and neck?
1) Spinal nerves
dorsal rami
ventral rami
-cervical plexus (C1-C4) –> ansa cervicalis portion is motor infrahyoid muscles (depress hyoid bone and larynx- they contract so suprahyoids can move tongue and open jaw), sensation in the neck
-phrenic nerve (C3-C5) –> innervate diaphragm for breathing, runs superficial to anterior scalene
-brachial plexus (C5-C8)
2) Cranial nerves
IX- Glossopharyngeal
X- Vagus (between and deep to common carotid artery and inferior jugular vein in the carotid sheath)
XI- Accessory
XII- Hypoglossal (runs laterally in suprahyoid space)
3) Sympathetic trunk
Superior C1-C4- contains all the postganglionic cell bodies for sympathetic neurons to the head
Middle C5-C6
Stellate C7-T1
*all preganglionic cell bodies in T1 lateral horn; distributed to head on blood vessels
What is the pharyngeal apparatus and what are the components?
Days 22-23 - pharyngeal arch development begins just before rostral neopore closes
Pharyngeal arch- pairs of lateral mesenchymal swellings that grow towards ventral midline where they fuse
ectoderm on outside as well as cleft, endoderm and pouch on inside, mesenchyme core
5 Pairs: 1, 2, 3, 4, 6
Each arch has:
-nerve
-artery
-cartilage
-mesenchyme (mesoderm invaded by neural crest cells- can form bone or cartilage)
What is the relationship between the pharyngeal arches and cranial nerves?
1- V, trigeminal 2- VII, facial 3- IX- glossopharyngeal 4- X, vagus (superior laryngeal) 6- X, vagus (recurrent laryngeal) *5, 7, 9, 10 are all the mixed sensory + motor cranial nerves
What is the relationship between the pharyngeal arches and aortic arches?
aortic arches follow pharyngeal arches (e.g. 1st aortic arch to 1st pharyngeal arch)
exception: 6th aortic arch
LHS: 6th arch retained, and recurrent laryngeal nerve hooks under 6th arch derivative- ductus arteriosus (which becomes ligamentum arteriosium) and ascends back up into the neck to go to larynx
RHS: 6th arch degenerates, recurrent laryngeal nerve hooks under 4th arch derivative- subclavian artery and comes back up into neck to go to larynx
*recurrent laryngeal nerves are branches of vagus X, they are called recurrent bc they mhhove in opp direction from the nerve they branch from
What is the relationship between the pharyngeal arches and the cartilage?
Cartilage contributes to bones of jaw and larynx
1- maxillary, mandible, malleus, incus
2- stapes, stapedius, styloid process, upper body/lower horn of hyoid
3- lower body/greater horn of hyoid
4- upper portion of thyroid cartilage
6- lower portion of thyroid cartilage + all other larynx cartilages
What is the relationship between the pharyngeal arches and muscles?
Muscles come from neural crest cells invading pharyngeal arches, somitomeres, or somites
*somitomeres alone lead to orbital muscles (away from spinal cord)
somites alone lead to muscles near spinal cord
*autonomic ganglia from neural crest, sensory ganglia from neural crest + placodes
1 (somitomeres + arch): muscles of mastication, tensor tympani + tensor palati, mylohyoid + anterior belly digastric
2 (somitomeres + arch): muscles of facial expression, stylohyoid + posterior belly digastric
3 (somitomeres + arch): stylopharyngeus (posterior 1/3 tongue)
4 (somites + arch): cricothyroid muscle
6 (somites + arch): intrinsic muscles of larynx
Describe the development of the tongue
1, 2, 3, 4 arches- tongue mesoderm
1, 3, 4- tongue endoderm –> sensory innervation
anterior 2/3: trigeminal (lingual nerve from mandibular V3 division)
posterior 1/3: glossopharyngeal
base of tongue + epiglottis: vagus
2, 3, 4- tongue endoderm –> taste fibers
anterior 2/3: facial (chorda tympani VII)
posterior 1/3: glossopharyngeal
base of tongue + epiglottis: vagus
Describe the development of the thyroid gland
- thyroid gland develops on the tongue in the foramen secum (b/w 1 and 2 pharyngeal arches, later separates anterior 2/3 from posterior 1/3 of tongue)
- connected to tongue through thyroglossal duct
- thyroid gland migrates caudally and ventrally, still attached to thyroglossal duct, to below the cricoid cartilage
- duct degenerates over time – if it doesnt you get cysts on ventral midline –> fistula or you get ectopic thyroid tissue (need to ID with X-ray)
Discuss the formation of pharyngeal pouches and their derivatives
1st pouch- middle ear + auditory tube (connects middle ear to nasopharynx to stabilize pressure, but closed to prevent infection), also the pouch combines with the cleft to make tympanic membrane
2nd pouch- tonsils
3rd pouch- inferior parathyroid gland + thymus (picked up first by the thyroid gland during migration)
4th pouch- superior parathyroid gland (picked up second by the thyroid gland)
Describe the formation of pharyngeal clefts/grooves and their derivatives
1st cleft- external auditory meatus and external ear canal (also combines with endoderm from 1st pharyngeal pouch to make tympanic membrane)
2, 3, 4 clefts- overgrown by the 2nd arch and creates cervical cyst/sinus that goes away
if it doesnt go away– leads to cysts along anterior border of sternocleidomastoid muscle (different location from the midline thyroid cysts)
Describe the development of the face
1) 1st pharyngeal arch develops maxillary prominence and mandibular arch inferior to it
plus there is midline frontonasal prominence
all 3 innervated by trigeminal nerve - maxillary, mandibular, and opthalmic divisions of CN V, respectively
2) mandibular arches come together and fuse –> lower jaw (can result in cleft chin if it doesnt fuse fully)
maxillary prominences fuse to the intermaxillary segments of the frontonasal prominence (remnant is philtrum)
Describe the development of the palate. How do cleft palates and lips originate?
1) Primary/hard palate- from frontonasal prominence, holds incisors
secondary/soft palate - fusion of palatine shelves (ie lateral palatal processes) from maxillary prominence, fuse to the primary palate
2) originate from failure to fuse
-isolated cleft palate: failure of palatine shelves to fuse
-cleft lip with cleft palate: failure of palatine shelves to fuse, also failure of intermaxillary segment (derivative of frontonasal process) to maxillary prominence to palatine shelf
-cleft lip: intermaxillary segment to maxillary prominence to palatine shelf (can be unilateral or bilateral)
-isolated cleft lip: intermaxillary segment to maxillary prominence
Where do sensory, motor, and mixed nerves go?
Sensory- from neural crest cells, neural crest induced by notochord and placode (ectodermal thickening invaded by neural crest cells that become ganglia or neural tissue layers)
Motor- somitomeres
Mixed- pharyngeal arches
What are the meninges? What is their relationship at spinal vs cranial levels?
Meninges- pia mater, arachnoid mater, dura mater
arachnoid mater and pia mater have same relationship at spinal and cranial levels - pia mater fused to brain/spinal cord, and arachnoid mater pushed against dura mater by CSF compression
in spinal cord, there is epidural space between dura mater and periosteum
at cranial level- there is no epidural space, dura and periosteum are fused together
Describe three sources of intercranial bleeding:
1) epidural hematoma
2) subdural hematoma
3) subarachnoid hematoma
1) branches of middle meningeal artery run between skull bone and periosteal dura
skull trauma –> torn artery –> bleeding –> creates epidural space filled with blood (epidural hematoma)
common site: lateral side near pterion
lucid interval after regaining consciousness while hematoma is forming and increased pressure causes loss of consciousness again
*does not cross suture lines in skull bc dura mater is very tightly bound
2) normally arachnoid is pressed against the dura mater
cortical/bridging veins bring venous blood from veins and penetrate arachnoid and dura to enter the sinus
blow to head –> veins tear right where they flow into sinus –> venous bleeding –> creates subdural space between arachnoid and dura (subdural hematoma)
onset is slower than epidural hematomas (slower leakage of blood from lower pressure veins)
*can cross suture lines in skull, can be caused by CSF leak
3) branches of vertebral and internal carotid arteries are on pia mater –> in subarachnoid space
aneurysm –> arterial rupture –> arterial blood enters subarachnoid space and mixes with CSF
Describe the spread of infection from extracranial to intracranial
emissary veins do not have valves so blood can flow into the cranial cavity is pressure gradient is switched –> can spread infection superficially (eg from pimple) into the cranial cavity –> can cause meningitis
What is hydrocephalus? Describe non-communicating vs communicating hydrocephalus
1) hydrocephalus- increased CSF resulting in increased CSF pressure
2) non-communicating - CSF obstructed from passing into the subarachnoid space
most common site is cerebral aqueduct - can tell based on which ventricle is enlarged
3) communicating - CSF can get into the subarachnoid space but is not adequately resorbed eg if there is meningeal infection
What is a tracheostomy? What is a cricothyrotomy?
Tracheostomy- incise thyroid isthmus and trachea and place tube to help with breathing
Cricothyrotomy- emergency procedure where you incise cricoid membrane bc you know you won’t be affecting your thyroid, but patient could lose voice box