Rubella Virus- Toga Virus

Question 1

Toga virus characteristics

Answer 1

small, enveloped, icosahedral capsid linear, ss+RNA

Question 2

Medically relevant species

Answer 2

Rubella virus

Arbovirus:

Eastern, Western and Venezuelan equine encephalitis viruses

Chikungunya

Question 3

Rubella virus Pathogenesis

Answer 3

Primary site of infection: local lymphnodes of URT

Rash first → then highly contagious

Question 4

Rubella

1- Transmission

2- Clinical course

3- Prevention

Answer 4

_ children can play around and appear normal: playing around wile infecting others.

Question 5

Congenital Rubella

1- Transmission

2- Clinical course

3- Prevention

Answer 5

Transplacental - Mothers who had not been immunized to rubella

Infx prior to 20 wks of gestation

Like majority of congenital viral infx: deafness

Question 6

Eastern and Western equine enceohalitis

1- Clinical manifestation

2- After-effect/ Complications

Answer 6

1. Transfered via the bite of mosquito (Arbovirus)
2. often towards the end of summer with mosquito bites

Question 7

Venezuelan equine encephalitis and Chikungunya

1- Clinical manifestation

2- After-effect/ Complications

Answer 7

Transfered via the bite of mosquito (Arbovirus)

Starting like flue → aseptic menangitis → coma

Chicungunya’s macular rash is peripheral with severe pripheral joint pain that returns

Chicungunya means “bent up” referrriing to the severity of the jt pain

Question 8

Lymph nodes that are typically involved in the clinical course of German measles

Answer 8

Postauricular

Question 9

congenital heart diseases that is most frequently associated with the transplacental transmission of rubella infection of the fetus

Answer 9

Patent ductus arteriosus